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  1. Michael Harrop

    Article The Poop Broker. Michael Harrop started a booming underground market for human feces. But something smells off about his product. (May 2024)

    https://slate.com/life/2024/05/fecal-transplant-fmt-c-diff-microbiome-poop-black-market.html Kind of an odd article. Amusing, seemingly agenda-driven, occasionally deceptive, but not all bad. I'm curious what impact this article will have. Will it be better or worse than the "complete silence"...
  2. Michael Harrop

    Study A long-term ketogenic diet accumulates aged cells in normal tissues (May 2024, mice) Ketogenic diet induces p53-dependent cellular senescence in multiple organs

    https://medicalxpress.com/news/2024-05-term-ketogenic-diet-accumulates-aged.html https://www.science.org/doi/10.1126/sciadv.ado1463
  3. Michael Harrop

    Article UK governments announce ban on wet wipes containing plastic (Apr 2024) "Wet wipes containing plastic are polluting our waterways and causing microplastics to enter the environment". 95% of respondents agreed or strongly agreed.

    https://www.circularonline.co.uk/news/uk-governments-announce-ban-on-wet-wipes-containing-plastic/ Nice to see the public and government supportive and taking steps to reduce plastic waste. Petition your own government to do the same!
  4. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    I posted about this a few years ago elsewhere and I'm copying all the info here for easy discussion. "While fecal microbiota is partially normalized by extended co-housing, mucosal communities associated with the proximal colon and terminal ileum remain stable and distinct". Comparison of...
  5. Michael Harrop

    Antibiotics Commonly used antibiotic brings more complications, death in the sickest patients (May 2024, n=7569) Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime

    https://www.eurekalert.org/news-releases/1044459 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2818278
  6. Michael Harrop

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    https://www.aginganddisease.org/EN/10.14336/AD.2024.0321
  7. Michael Harrop

    Study BMJ investigation on financial entanglements between FDA chiefs and the drug industry (May 2024) Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry

    https://medicalxpress.com/news/2024-05-financial-entanglements-fda-chiefs-drug.html https://www.bmj.com/content/385/bmj.q975
  8. Michael Harrop

    Other Removing gut bacteria's potential 'safe house' (appendix) may lower risk of colorectal cancer subtype (May 2024, n=139,406) Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status

    https://medicalxpress.com/news/2024-05-gut-bacteria-potential-safe-house.html https://journals.lww.com/annalsofsurgery/abstract/9900/appendectomy_and_long_term_colorectal_cancer.870.aspx The appendix, once dismissed as an unnecessary human organ, has more recently been shown to play a role in...
  9. Michael Harrop

    Study Chemicals in car interiors may cause cancer — and they’re required by US law (May 2024) Flame Retardant Exposure in Vehicles Is Influenced by Use in Seat Foam and Temperature

    https://thehill.com/policy/energy-environment/4649281-chemicals-car-interiors-cancer-required-federal-law-study/ https://pubs.acs.org/doi/10.1021/acs.est.3c10440
  10. Michael Harrop

    Antibiotics Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks (May 2024, mice)

    https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01795-z
  11. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjae066/7665392 Yet another FMT trial harming patients and extending the unavailability of FMT due to using low-quality donors.
  12. Michael Harrop

    Vaccines Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? (May 2024, NYT) All vaccines have at least occasional side effects. But people who say they were injured by Covid vaccines believe their cases have been ignored.

    https://www.nytimes.com/2024/05/03/health/covid-vaccines-side-effects.html I've seen this same attitude and dismissal when the harms of antibiotics are brought up in laypeople communities.
  13. Michael Harrop

    Prebiotics Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model (Mar 2024) Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation

    https://medicalxpress.com/news/2024-05-common-fiber-trigger-bowel-inflammation.html https://rupress.org/jem/article-abstract/221/5/e20232148/276641/Dietary-fiber-is-a-critical-determinant-of Another example of possible detriments from prebiotics https://humanmicrobiome.info/prebiotics/#detriments.
  14. Michael Harrop

    Oral Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes (May 2024)

    https://www.nature.com/articles/s41564-024-01680-3 A useful addition to the "Does the oral microbiome colonize the gut?" question.
  15. Michael Harrop

    Early development Father's gut microbes affect the next generation (May 2024, mice) Paternal microbiome perturbations impact offspring fitness

    https://medicalxpress.com/news/2024-05-father-gut-microbes-affect-generation.html https://www.nature.com/articles/s41586-024-07336-w
  16. Michael Harrop

    Phages A virus could help save billions of gallons of wastewater produced by fracking (Mar 2024) Using Bacteriophages to Treat Resilient Bacteria Found in Produced Water

    https://www.eurekalert.org/news-releases/1042964 https://www.mdpi.com/2073-4441/16/6/797
  17. Michael Harrop

    Article Multicellular Bacteria Evolve Defenses that Resemble the Immune System (Apr 2024)

    https://www.the-scientist.com/multicellular-bacteria-evolve-defenses-that-resemble-the-immune-system-71807
  18. Michael Harrop

    Antibiotics Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk (Apr 2024)

    https://www.jacionline.org/article/S0091-6749(24)00409-3/fulltext An increased number of antibiotic courses corresponded to a dose-response-like increased risk https://www.medpagetoday.com/dermatology/atopy/109868
  19. Michael Harrop

    FMT Changes in the Progression of Chronic Kidney Disease in Patients Undergoing Fecal Microbiota Transplantation (Apr 2024, n=28) "oral FMT in patients with CKD is a safe strategy, does not represent a risk, and has potential benefits"

    https://www.mdpi.com/2072-6643/16/8/1109
  20. Michael Harrop

    FMT Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study (Apr 2024, n=45) "The total effective rate was higher in the FMT group (90.9%) compared to the control group (56.5%) after 6 months of treatment"

    https://www.jpain.org/article/S1526-5900(24)00455-3/abstract
  21. Michael Harrop

    Other Gut microbiome predicts cognitive function and depressive symptoms in late life (Apr 2024, n=268)

    https://www.nature.com/articles/s41380-024-02551-3
  22. Michael Harrop

    Vaccines Universal vaccine may be effective against any variant of any virus (Apr 2024) Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells

    https://www.earth.com/news/universal-vaccine-may-be-effective-against-any-variant-of-any-virus/ https://medicalxpress.com/news/2024-04-vaccine-strategy-line-endless-boosters.html https://www.pnas.org/doi/10.1073/pnas.2321170121
  23. Michael Harrop

    Antibiotics Large study finds antibiotics aren't effective for most lower tract respiratory infections (Apr 2024, n=718) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection

    https://medicalxpress.com/news/2024-04-large-antibiotics-effective-tract-respiratory.html https://link.springer.com/article/10.1007/s11606-024-08758-y And they STILL largely ignore the effects of collateral damage of antibiotics https://humanmicrobiome.info/antibiotics/.
  24. Michael Harrop

    FMT Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation (Apr 2024)

    https://www.sciencedirect.com/science/article/abs/pii/S0014488624001006
  25. Michael Harrop

    The gut microbiome, COVID-19, and long COVID [collection of studies]

    I saw news about "Chairman Bernie Sanders Releases Long COVID Moonshot Legislative Proposal", and I wanted to make a post listing the research I've seen on this. From what I see in their proposal, they're allocating 1 billion dollars into general research. I find this very frustrating given...
  26. Michael Harrop

    Other Infections after surgery are more likely due to bacteria already on your skin than from microbes in the hospital. Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery (Apr 2024, n=204)

    https://theconversation.com/infections-after-surgery-are-more-likely-due-to-bacteria-already-on-your-skin-than-from-microbes-in-the-hospital-new-research-227435 https://www.science.org/doi/10.1126/scitranslmed.adk8222
  27. Michael Harrop

    FMT Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice (Apr 2024)

    https://www.nature.com/articles/s41537-024-00460-6
  28. Michael Harrop

    Article Decaf coffee is not safe for human consumption, health advocacy group warns (Apr 2024)

    https://www.wfsb.com/2024/04/06/decaf-coffee-is-not-safe-human-consumption-health-advocacy-group-warns/ Is decaf coffee safe to drink? Experts weigh in on claims by health advocacy groups https://www.cnn.com/2024/04/04/health/decaf-coffee-methylene-chloride-cancer-wellness/index.html
  29. Michael Harrop

    FMT FDA warning over 'gut-boosting' pills that contain other people's POOP, amid links to deadly bacterial infections (Apr 2024, DailyMail, Human Microbes)

    https://web.archive.org/web/20240406175051/https://www.dailymail.co.uk/wellness-us/article-13238001/FDA-warning-poop-pills-infection.html The article gets some things wrong, such as: Nowhere in the FDA letter does it say "mislead" or "harm" or "false". Things like this are why the Daily Mail...
  30. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    Katie McCaskey wrote to me on Mastodon: I took a look at the link and I'm working on writing up something about FMT/Human Microbes to submit, but I see "What are specific steps the federal government can take to implement your solution?". I'm doubtful that the feds are the best option to...
  31. Michael Harrop

    FMT Fecal Microbiota Transplantation engraftment after budesonide or placebo in patients with active ulcerative colitis using pre-selected donors: a randomized pilot study (Apr 2024, n=24) "clinical response appeared donor-dependent"

    https://academic.oup.com/ecco-jcc/advance-article/doi/10.1093/ecco-jcc/jjae043/7640395
  32. Michael Harrop

    FMT Fecal microbiota transplant eases Parkinson’s symptoms (Mar 2024, n=46) Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial

    https://parkinsonsnewstoday.com/news/fecal-microbiota-transplant-eases-parkinsons-symptoms-trial/ https://www.sciencedirect.com/science/article/pii/S2589537024001421 Standard, poor donor quality. Stool type not even considered. 0% chance they found 17 high-quality donors.
  33. Michael Harrop

    FMT Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report (Mar 2024)

    https://academic.oup.com/smoa/article/12/2/qfae015/7636150
  34. Michael Harrop

    Other Scientists link certain gut bacteria to lower heart disease risk (April 2024, n=1429) Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

    https://medicalxpress.com/news/2024-04-scientists-link-gut-bacteria-heart.html https://www.cell.com/cell/abstract/S0092-8674(24)00305-2 More commentary: Gut bacteria break down cholesterol — hinting at probiotic treatments. Species in the human microbiome have enzymes that can metabolize a...
  35. Michael Harrop

    Article US appeals court kills ban on plastic containers contaminated with PFAS. Conservative fifth circuit overturns EPA’s ban prohibiting Inhance from using manufacturing process creating toxic compound (Mar 2024)

    https://www.theguardian.com/us-news/2024/mar/30/pfas-ban-plastic-containers-court
  36. Michael Harrop

    Study Amount of protein consumed by pregnant women modulates the facial appearance of offspring (Mar 2024, mice) The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling

    https://medicalxpress.com/news/2024-03-amount-protein-consumed-pregnant-women.html https://www.nature.com/articles/s41467-024-46030-3 Cool!
  37. Michael Harrop

    Antibiotics Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung (Mar 2024)

    https://www.nature.com/articles/s41467-024-47149-z
  38. Michael Harrop

    Other Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis (Mar 2024, mice & humans)

    https://www.nature.com/articles/s41421-024-00665-0
  39. Michael Harrop

    Study Common household chemicals pose threat to brain health. (Mar 2024) Pervasive environmental chemicals impair oligodendrocyte development

    https://medicalxpress.com/news/2024-03-common-household-chemicals-pose-threat.html https://www.nature.com/articles/s41593-024-01599-2
  40. Michael Harrop

    Study Ultra-Processed Food Consumption and Long-Term Risk of Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study (Mar 2024, N=178,711) "higher UPF consumption is associated with an increased risk of incident IBS, with a significant dose-response relationship"

    https://www.sciencedirect.com/science/article/abs/pii/S154235652400168X
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