FMT Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report (Mar 2024)

[Michael Harrop]

https://academic.oup.com/smoa/article/12/2/qfae015/7636150

Abstract​

Introduction
Postorgasmic illness syndrome (POIS) is characterized by allergic symptoms and flu-like illness after ejaculation. There are still no effective treatments for POIS.

Aim
To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.

Methods
Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient’s stool samples for 16sDNA sequencing were collected 1 month after WMT.

Results
POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient’s gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.

Conclusion
WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.

 

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For reference, This is the Nanjing procedure:

1) Feces should preferably be collected on-site in a disposable feces container in a dedicated room only for donors

2) All devices directly contacting fecal matters used for the fecal collection, suspension filtration, centrifugation, and washing should be disposable

3) Feces from adults less than 50 g are not recommended proceeding in the process using an automatic purification system for enriching microbiota

4) The fecal suspension is transferred to centrifugation tubes for centrifugation with 700 x g for 3 min and discard the supernatant

5) This is repeated three times using sterile saline to make the suspension

6) 10 cm³ (about 1.0 x 1013 bacteria) of final precipitated microbiota is the basic unit dose for clinical use. The volume ratio of final precipitation/vector solution is 1:2 for making suspensions as fresh or frozen use

7) Anaerobic fecal processing is encouraged if possible