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  1. Michael Harrop

    FMT Fecal Microbiota Transplantation, a tool to transfer healthy longevity (Review, Nov 2024)

    https://www.sciencedirect.com/science/article/pii/S1568163724004033
  2. Michael Harrop

    Review Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks (Review, Nov 2024)

    https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1492759/full
  3. Michael Harrop

    FMT Transplant of gut microbiota ameliorates metabolic and heart disorders in rats fed with a hypercaloric diet by modulating microbial metabolism and diversity (Nov 2024)

    https://www.sciencedirect.com/science/article/pii/S0753332224015531
  4. Michael Harrop

    FMT Clinical efficacy of washed microbiota transplantation on metabolic syndrome and metabolic profile of donor outer membrane vesicles (Nov 2024, n=65) "WMT had significant short-term and medium-term clinical efficacy in MetS"

    https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1465499/full
  5. Michael Harrop

    FMT Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas explosion (Oct 2024)

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1485936/full
  6. Michael Harrop

    Diet Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice (Jun 2024) Lecithin, sucrose fatty acid esters, carboxymethylcellulose (CMC), and mono- and diglycerides (MDG)

    https://www.nature.com/articles/s42003-024-06224-3
  7. Michael Harrop

    FMT Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s disease (Nov 2024, n=34) "FMT was not effective "

    https://journals.lww.com/ajg/abstract/9900/preliminary_results_from_a_multicenter,_randomized.1438.aspx Appears to be standard poor donor quality criteria.
  8. Michael Harrop

    Other Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice (Nov 2024)

    https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1407936/full
  9. Michael Harrop

    FVT Researchers at the University of Copenhagen have been cultivating "good viruses" from feces (Jul 2024) Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material

    https://medicalxpress.com/news/2024-11-fermented-feces-transplant-capsules-treatment.html https://www.cell.com/iscience/fulltext/S2589-0042(24)01685-7
  10. Michael Harrop

    FMT Fecal microbiota transplantation alleviates neuronal Apoptosis, necroptosis and M1 polarization of microglia after ischemic stroke (2024, rats)

    https://www.sciencedirect.com/science/article/abs/pii/S0306452224005761
  11. Michael Harrop

    Video Is SIBO real? SIBO vs dysbiosis? Debunking the SIBO hypothesis | Small Intestinal Bacterial Overgrowth

    https://humanmicrobiome.info/sibo/ https://www.youtube.com/watch?v=pjRNwFqwxBk
  12. Michael Harrop

    FMT Fecal microbiota transplantation against moderate-to-severe atopic dermatitis: A randomized, double-blind controlled explorer trial (Oct 2024, n=)

    https://onlinelibrary.wiley.com/doi/10.1111/all.16372 Closed access Chinese study, and the abstract doesn't say how many patients or give many details. Take this with a grain of salt.
  13. Michael Harrop

    Video What is the best probiotic? How to choose a probiotic? Are fermented foods better? | Probiotic guide

    https://humanmicrobiome.info/probiotic-guide/ https://www.youtube.com/watch?v=UG7zP-vmYqo
  14. Michael Harrop

    FMT Microbiota Transplantation in Individuals with Type 2 Diabetes and a High Degree of Insulin Resistance (Oct 2024, n=21) "neither FMT from healthy and lean donors nor a probiotic were effective"

    https://www.mdpi.com/2072-6643/16/20/3491 Another failed FMT trial. Ridiculous criteria. What a joke. Completely incompetent research system. Huge waste of time and money.
  15. Michael Harrop

    Antibiotics Antibiotic-induced dysbiosis leads to neuroinflammatory and neurobehavioral impairments via breaching the gut-blood-brain barrier (Sep 2024) An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice

    Study links gut bacteria infection to Alzheimer's disease progression https://www.news-medical.net/news/20241024/Study-links-gut-bacteria-infection-to-Alzheimers-disease-progression.aspx https://academic.oup.com/jid/article/230/Supplement_2/S95/7754705
  16. Michael Harrop

    Aging Maternal dysbiosis produces long-lasting behavioral changes in offspring (Oct 2024, mice) "pre-pregnancy colonization of young dams with microbiome from aged female donors significantly increased fetal loss. Offspring displayed persistent depressive and anxiety-like phenotypes"

    https://www.nature.com/articles/s41380-024-02794-0
  17. Michael Harrop

    Other Tire-wear particle leachate at environmentally relevant concentrations exert a hepatotoxic impact on the black-spotted frog by disrupting the gut–liver axis (2024)

    https://www.eurekalert.org/news-releases/1062179 https://www.sciencedirect.com/science/article/pii/S2590182624000341 Tires are the #1 source of microplastic pollution.
  18. Michael Harrop

    Other Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota (Oct 2024, n=10)

    https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2416912 This is good news that suggests we won't need more invasive methods of FMT. There is some conflicting data here: Mucosal microbiota transplant, clearing the gut mucosa prior to FMT
  19. Michael Harrop

    Video Is dirt good for your microbiome? Will eating dirt improve gut health? Debunking the Hygiene Hypothesis

    https://www.youtube.com/watch?v=P-cJa7iw9nU According to the Hygiene Hypothesis, exposure to germs is necessary to train and strengthen our immune system right? This notion is widespread, both on social media and in books written by microbiologists and doctors. But it has largely been...
  20. Michael Harrop

    Other Study links PFAS exposure to kidney function decline via gut microbiome (Oct 2024, n=78) The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study

    https://medicalxpress.com/news/2024-10-links-pfas-exposure-kidney-function.html https://www.sciencedirect.com/science/article/abs/pii/S0048969724066750 Graphical abstract
  21. Michael Harrop

    Video Are prebiotics better than probiotics? | FAQ | Some people say probiotics generally don't colonize the gut and thus prebiotics are better. Is this true?

    https://www.youtube.com/watch?v=L3lBr7FMdmQ https://humanmicrobiome.info/faq/#prebiotics-vs-probiotics
  22. Michael Harrop

    Other Possible trigger of Crohn's disease discovered: Dysfunctional mitochondria disrupt the gut microbiome (Jul 2024, mice) Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

    https://www.msn.com/en-us/health/other/possible-trigger-of-crohn-s-disease-discovered-dysfunctional-mitochondria-disrupt-the-gut-microbiome/ar-AA1s6Ddd https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00231-2 Graphical abstract
  23. Michael Harrop

    Video Should I do autologous FMT (aFMT) to restore my microbiome after I take antibiotics? | FAQ, fecal microbiota transplants

    https://www.youtube.com/watch?v=Acv3SA-sC2w https://humanmicrobiome.info/faq/#what-about-autologous-fmt
  24. Michael Harrop

    Video If I get bad side effects after eating something good is it die-off? A Herxheimer reaction? Keto flu? | Microbiome FAQ

    https://www.youtube.com/watch?v=PIG7zf1MQXQ https://humanmicrobiome.info/faq/#is-it-die-off-a-herx-reaction-keto-flu
  25. Michael Harrop

    Causation Gut microbiota causally impacts adrenal function: a two-sample mendelian randomization study (Oct 2024)

    https://www.nature.com/articles/s41598-024-73420-w
  26. Michael Harrop

    Prebiotics Experts propose key criteria to classify prebiotics (Oct 2024) Classifying compounds as prebiotics — scientific perspectives and recommendations

    https://medicalxpress.com/news/2024-10-experts-key-criteria-prebiotics.html https://www.nature.com/articles/s41575-024-00981-6
  27. Michael Harrop

    Antibiotics The effect of antibiotics on the intestinal microbiota in children - a systematic review (Oct 2024) "ABX have profound effects; long-lasting consequences"

    https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1458688/full
  28. Michael Harrop

    FMT Safety and Tolerability of CP101, a full spectrum, oral microbiome therapeutic for the prevention of recurrent C. difficile infection: A Phase 2 Randomized Controlled Trial (Oct 2024, n=198, Finch) 75% efficacy vs 62% for placebo. Adverse events similar in both groups

    https://www.gastrojournal.org/article/S0016-5085(24)05536-7/abstract Lots of recognizable names. Closed access. Drug by Finch. Finch Therapeutics Presents Positive Data from PRISM3 Clinical Trial of CP101 (2021)...
  29. Michael Harrop

    Probiotics Popular gut probiotic, Activia, completely craps out in randomized controlled trial (Oct 2024, n=228) Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation. A Randomized Clinical Trial

    https://arstechnica.com/health/2024/10/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial/ https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824333
  30. Michael Harrop

    Phages An alternative to antibiotics could work wonders in Africa. It isn’t being used. Bacteria-eating viruses might be able to fight antibiotic resistance where new treatments are most needed. (Oct 2024)

    https://www.vox.com/the-highlight/373174/phage-therapy-antiobiotic-resistance-africa-innovation
  31. Michael Harrop

    Other Circadian disruption, gut microbiome changes linked to colorectal cancer progression (Sep 2024) Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer

    https://www.sciencedaily.com/releases/2024/09/240930123309.htm https://www.science.org/doi/10.1126/sciadv.ado1458
  32. Michael Harrop

    Antibiotics Antibiotics given in infancy can disrupt development of the microbiome, resulting in increased levels of aggression later in life (Aug 2024, humanized mice) A gut reaction? The role of the microbiome in aggression

    https://www.israel21c.org/mice-given-antibiotics-as-babies-become-more-aggressive/ https://www.sciencedirect.com/science/article/pii/S0889159124005336 I've had quite a bit of experience with highly aggressive people who seem to have taken lots of antibiotics.
  33. Michael Harrop

    Phages Not so selfish after all: Viruses weaponize selfish genetic elements known as “mobile introns” to disrupt the ability of competing phages to reproduce (Jul 2024) An intron endonuclease facilitates interference competition between coinfecting viruses

    https://www.asbmb.org/asbmb-today/science/092824/viruses-use-freeloading-genes-as-weapons https://www.science.org/doi/10.1126/science.adl1356
  34. Michael Harrop

    FMT Fecal microbiota transplantation from patients with polycystic ovary syndrome induces metabolic disorders and ovarian dysfunction in germ-free mice (Sep 2024, PCOS)

    https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-024-03513-z
  35. Michael Harrop

    Other The gut microbiome can influence hormone levels (Sep 2024, mice) Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota

    https://medicalxpress.com/news/2024-09-gut-microbiome-hormone-mouse.html https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011395
  36. Michael Harrop

    Causation Cleveland Clinic researchers discover new bacterium (Tomasiella immunophila) that causes gut immunodeficiency (Sep 2024) A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency

    https://www.eurekalert.org/news-releases/1058963 https://www.science.org/doi/10.1126/science.adk2536
  37. Michael Harrop

    Genetics Bacterial ‘flipping’ allows genes to encode multiple versions of themselves and assume different forms, altering a core understanding of genetics (Sep 2024) Intragenic DNA inversions expand bacterial coding capacity

    https://med.stanford.edu/news/all-news/2024/09/gene-flipping.html https://www.nature.com/articles/s41586-024-07970-4
  38. Michael Harrop

    Other Environmental Pollutants Play a Growing Role in IBD (Aug 2024) Emerging role of environmental pollutants in inflammatory bowel disease risk, outcomes and underlying mechanisms

    https://www.mdedge.com/gihepnews/article/270947/ibd-intestinal-disorders/environmental-pollutants-play-growing-role-ibd https://gut.bmj.com/content/early/2024/08/30/gutjnl-2024-332523
  39. Michael Harrop

    FMT Fecal Transplants Reduce ADHD, Anxiety Symptoms In Dogs With Epilepsy (Jun 2024, n=9) Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: a pilot study of a novel therapeutic approach

    https://today.tamu.edu/2024/09/24/fecal-transplants-reduce-adhd-anxiety-in-dogs/ https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1385469/full Bizarre. The stool donor had epilepsy. Why not use a healthy dog to see if you can cure the epilepsy too?
  40. Michael Harrop

    Other People with Alzheimer's seem less likely to develop certain types of cancer. A new study hints at why (Sep 2024) Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance

    https://www.sciencealert.com/mysterious-link-between-alzheimers-and-cancer-may-finally-be-explained https://www.pnas.org/doi/10.1073/pnas.2314337121
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