Fecal Microbiota Transplantation, a tool to transfer healthy longevity (Review, Nov 2024) FMT 

Fecal Microbiota Transplants

Michael Harrop

Active member
Joined
Jul 6, 2023
Messages
858
Location
USA
https://www.sciencedirect.com/science/article/pii/S1568163724004033

Highlights​

  • Gut microbiome rejuvenation restores a healthy gut and promotes healthy aging.
  • Preconditioning healthy donors enhances FMT benefits.
  • FMT challenges like regulations and safety concerns need to be addressed.

Abstract​

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity.

Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable.

Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly.
 
Format correct?
  1. Yes
Back
Top