Other Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota (Oct 2024, n=10)

Michael Harrop

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https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2416912

ABSTRACT​

The appropriateness of the fecal microbiota to adequately reflect the gut microbiota composition from more difficult to access luminal content at different colonic locations has been debated.

Here, in a healthy population, luminal samples were collected from terminal ileum to rectum using an unique sampling technique without the need of prior bowel cleansing/preparation. Rectal swabs were collected immediately prior colonoscopy by an experienced physician, and fecal samples were collected at home by the participants themselves.

Microbiota composition was evaluated as relative abundance, α-diversity and Bray–Curtis dissimilarities.

Our data suggest that fecal samples and rectal swabs present noninvasive, easily accessible, low-cost sampling tools that are accurate proxies to characterize luminal large intestinal microbiota composition.

This is good news that suggests we won't need more invasive methods of FMT. There is some conflicting data here:
Mucosal microbiota transplant, clearing the gut mucosa prior to FMT
 
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