Re crapsules, what are the optimal conditions to consume them? Procedure

[john silver]

hello. just wanted to ask if it's better to consume them frozen or wait for them to thaw out, to consume a bunch of them together or to take a small amount everyday for a while, what I know so far is that it's best taken an empty stomach and to be fasting for some hours afterwards. if a person needed to finish their crapsules asap for time limtiations, would taking 50-100 caps in a single day be wise? would it be less effective? do let me know all the science behind this that you know.

 

[Michael Harrop]

This is covered here:

• https://www.humanmicrobes.org/ordering-faq
• https://humanmicrobiome.info/fmt/

Much of it is experimental.

would taking 50-100 caps in a single day be wise? would it be less effective?

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In my experience, a huge dose like that is much less effective than small doses spread out for a long period. I think it has to do with colonization resistance.

 

[john silver]

I see. thanks for the links. about colonization resistance, it typically happens because there're already a lot of bacteria in the gut right? what if someone's gut was 99% devoid of bacteria after heavy antibiotics? what are all the things that affect colonization resistance?

 

[Michael Harrop]

about colonization resistance, it typically happens because there're already a lot of bacteria in the gut right?

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Yes, but it's much more than that. There's also the mucus layer and the immune system. There are many components of the gut microbiome that hinder colonization.

what if someone's gut was 99% devoid of bacteria after heavy antibiotics?

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No such thing. The closest thing is "germ-free mice". Antibiotics have not worked for this purpose in humans: https://humanmicrobiome.info/fmt/#before-the-procedure

There are more links and discussion here: https://forum.humanmicrobiome.info/threads/mucosal-microbiota-transplant-clearing-the-gut-mucosa-prior-to-fmt.393/

 

[john silver]

so, could you explain to me in what cases would the mucus layer and immune system hinder colonization? is it a genetic difference, like some people just have more mucus? and in case of immune system, I'm guessing inflammation would be the biggest known factor is that right? since it kills bacteria and all.

 

[Michael Harrop]

so, could you explain to me in what cases would the mucus layer and immune system hinder colonization?

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Virtually every case. That's one of their main functions.