DNA stool analysis before and after FMT? Outcomes

[Raptor]

I've been DNA stool testing my microbiome for close to three years every 3 months. I had been through 10 rounds of antibiotics over a few years and was left with severe cramping, hypersensitivity, histamine reactions, as well as other issues. I was left with diversity in the 5th percentile. I became very familiar with the DNA results and reading the reports.

Is there any evidence of what your biome looked like before and after an FMT? I could see what 1 round of antibiotics did my comprised biome from the DNA testing during real time. I had multiple DNA tests done before and after a round of metronidazole and could clearly see how it impacted my biome initially and over time. I would like to see similar evidence before and after FMT.

 

[SFBayFMT5]

How about you re-test after doing a FMT, since you're familiar with your pre-FMT results?

As far as existing data, if you read almost any scientific paper about FMT they will show pre- and post-FMT microbiome data from the recipients, organized by phylum, genus, and sometimes species. They quite often will also show the microbiome profile of the donor(s).

In general, the recipients' microbiomes change in the direction of their donor, though not "all the way" (in other words, they don't acquire ALL species from the donor, and often not to the level of abundance of the donor, rather partway between the donor and their starting abundance). This the overall big picture, sometimes bacteria increase in the recipient that weren't found in the donor. And among the ones that DO shift toward the donor, it's often highly skewed in terms of which change how much, in other words the recipient doesn't move proportionally along a line connecting his/her starting profile to the donor's, but instead might move 90% of the way toward the donor along some dimensions and only 15% of the way along others. Also how durable the change is varies widely.