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  1. Michael Harrop

    Study Man on carnivore diet develops yellowish nodules on his hands, feet and elbows from cholesterol build-up (Jan 2025) Yellowish Nodules on a Man Consuming a Carnivore Diet

    https://medicalxpress.com/news/2025-01-carnivore-diet-yellowish-nodules-feet.html https://jamanetwork.com/journals/jamacardiology/article-abstract/2828915
  2. Michael Harrop

    Impact of gut health on food poisoning or sensitivities

    Even so, I don't think "they add more beneficial bacteria to your microbiome and increase gut health" is correct. I don't think there's strong evidence that they're only beneficial for most people (or healthy people) and able to increase gut health. Studies have identified some possible mild...
  3. Michael Harrop

    Impact of gut health on food poisoning or sensitivities

    This is not good general advice, and is largely misinformation. https://humanmicrobiome.info/probiotic-guide/
  4. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    Glelatin won't do it. One recipient was experimenting with various coatings & combinations but they haven't posted it publicly. That's not the only method in the wiki.
  5. Michael Harrop

    Other Developmental inequity and the impact of pesticide exposure on gut and brain health in developing nations – a Brazilian perspective (Feb 2025)

    https://www.nature.com/articles/s41599-024-04229-1 A lot of people suggest recruiting stool donors from developing countries. This is one example of lax regulations in those countries that raise concerns about recruiting donors there. I've seen many things like this across many developing...
  6. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    Generally, that's correct. There appears to be a benefit if you can coat the whole colon. For instance, this is where colonization resistance comes into play. If you can directly coat an area with the new microbes, that's likely to have a stronger effect vs them having to migrate on their own...
  7. Michael Harrop

    FMT The influence of microplastics on hypertension-associated cardiovascular injury via the modulation of gut microbiota (Jan 2025)

    https://www.sciencedirect.com/science/article/abs/pii/S0269749125001332
  8. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Senator Cassidy: I have been waiting outside Senator Cassidy's office most days. At first, it seemed like he and his staff were avoiding me, but then for two days in a row he acknowledged me and I nodded to him without saying anything. He finally approached me and said hello and I asked him if...
  9. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    RFK Senate hearings: Day 1: https://www.congress.gov/event/119th-congress/senate-event/336563?s=1&r=6 or https://www.youtube.com/watch?v=4JzVh83xVrk Day 2: https://www.congress.gov/event/119th-congress/senate-event/336566?s=1&r=12 or https://www.youtube.com/watch?v=iOe4ie1XaA4 Day 2 was held...
  10. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025)

    HHS Office for Human Research Protections (OHRP) I submitted a complaint via https://oashsps.my.site.com/ohrpwebforms/s/complaint-web-form. The result: Case closed, we don't care, you have to do a ton of work for us, it's not our job to prevent this harm to patients. The first response: My...
  11. Michael Harrop

    Early development Maternal allergy status, infant birth season impact milk microbiome of mothers (Dec 2024, n=196) Maternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk Microbiome

    https://www.healio.com/news/allergy-asthma/20250130/maternal-allergy-status-infant-birth-season-impact-milk-microbiome-of-mothers https://onlinelibrary.wiley.com/doi/10.1111/all.16442
  12. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    It's factual information that needs to be said because you can't solve a problem without diagnosing it first. If you have alternative theories for the state of things, or counter arguments against my statements, you're free and encouraged to write them. My criticisms are backed by a plethora of...
  13. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    You can use the "Bypass paywalls clean" addon, or archive.today: https://archive.fo/BuBSa
  14. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025)

    NIH would have to make the required changes first. NIH does not do that kind of thing currently.
  15. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025)

    Everything that's happened over the past few months, plus these recent studies [1][2][3], was the catalyst for this post. And despite all this, they have the audacity to constantly write stuff like: "Don't take things into your own hands; leave everything up to us. We're the only ones competent...
  16. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025)

    Since my first letters in 2018 to both the NIH and FDA, nothing has changed. Tens of millions of dollars continue to be wasted on FMT clinical trials with low-quality donors, patients continue to be harmed, and safe & effective FMT continues to be unavailable, and neither the NIH nor FDA seems...
  17. Michael Harrop

    Outcomes Please help - anxiety/panic after FMT+yellow stool

    You should format that properly with paragraphs to make it easier to read -- if you want people to read it and help. Some people get lucky and don't get worse from bad donors. There are also people who lie and astroturf to promote certain sources. "A healthy, slim woman, with no mental...
  18. Michael Harrop

    Review Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms (Jan 2025)

    https://www.mdpi.com/2076-2607/13/1/90
  19. Michael Harrop

    FMT Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS (Jan 2025, n=793) 4.2% serious adverse events, 79% success rate.

    https://academic.oup.com/ibdjournal/advance-article/doi/10.1093/ibd/izae291/7979239 Subgroup of this study: PUNCH CD3-OLS: a phase 3 prospective observational cohort study to evaluate the safety and efficacy of fecal microbiota, live-jslm (REBYOTA) in adults with recurrent Clostridioides...
  20. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Update on RFK hearings: https://forum.humanmicrobiome.info/threads/incoming-trump-admin-with-rfk-signals-new-start-for-fda.706/post-2036 I don't think the general public can just make an appointment to see someone at the NIH Director's office/building. I just checked their website and I don't...
  21. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I'm still in DC and have been visiting Senator Bill Cassidy's (GI doctor, head of Health Committee) office most days. RFK has two hearings coming up at 10 am Eastern on Wednesday and Thursday. https://www.senate.gov/committees/hearings_meetings.htm I usually wake up after 10 am, and my...
  22. Michael Harrop

    Procedure Effect on FMT storage long term in -20c freezer

    A regular home freezer. I updated the FAQ.
  23. Michael Harrop

    FMT Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect (Jan 2025, n=20) 3 patients developed severe aGVHD from Donor 1

    https://www.nature.com/articles/s41467-025-56375-y Mainly a group from the University of Washington, plus Alexander Khoruts from the University of Minnesota. Absolutely ridiculous that they think these are the important donor factors to list. 0 results for "stool type". And I don't see any...
  24. Michael Harrop

    Probiotics Genomic interrogation of commercial infant probiotic products for label accuracy (Jan 2025) "Most bacterial species in commercial infant probiotic products are accurately represented on labels"

    https://www.nature.com/articles/s41390-025-03831-6
  25. Michael Harrop

    Study Q&A: Assessing, addressing poor diet quality during pregnancy. Lower education & income, & high BMI are risk factors for low diet quality (Nov 2024) Diet quality from early pregnancy through 1-y postpartum: a prospective cohort study

    https://www.healio.com/news/womens-health-ob-gyn/20250124/qa-assessing-addressing-poor-diet-quality-during-pregnancy https://www.sciencedirect.com/science/article/abs/pii/S0002916524007482
  26. Michael Harrop

    Antibiotics Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants (Jan 2025, n=323) Predominantly amoxicillin. Short and long-term perturbations were detectable but substantially smaller than those associated with breastfeeding and infant age

    https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01999-3
  27. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    FMT is a serious undertaking and it appears that you haven't reviewed the wiki at all. You really need to do that if you don't want to end up worse off. You can also do a "ctrl+f" in this category (/forums/fecal-microbiota-transplant-fmt/) for "sibo" and see other discussions. You can also...
  28. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    What you said is not accurate. Firstly, his staffers should know as much as him. They're the ones who have to review everything and discuss it with him, then create policies, bills, etc. It's also notable that despite me having very low expectations of people and constantly bemoaning how...
  29. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Thanks @indigo34 for accompanying me to the Senate offices for a day! Hopefully two people will be twice as effective :) NIH: I confirmed that Building 1 is where the Office of the Director is. https://orf.od.nih.gov/AboutORF/BFM/Pages/01Beth.aspx I contacted ORS...
  30. Michael Harrop

    FMT Exercised gut microbiota improves vascular and metabolic abnormalities in sedentary diabetic mice through gut‒vascular connection (Jan 2025)

    https://www.sciencedirect.com/science/article/pii/S2095254625000043
  31. Michael Harrop

    FVT Bacterial and viral assemblages in ulcerative colitis patients following fecal microbiota and fecal filtrate transfer (Dec 2024, n=6)

    https://academic.oup.com/ismecommun/article/5/1/ycae167/7931473 Some interesting findings. A comparison of FVT & FMT.
  32. Michael Harrop

    Antibiotics Shorter, smarter, safer: Short-course antibiotics can revolutionize healthcare (Nov 2024, n=460) Cost-effectiveness of a short-course antibiotic treatment strategy for the treatment of ventilator-associated pneumonia: an economic analysis of the REGARD-VAP trial

    https://www.sciencedaily.com/releases/2025/01/250121130033.htm https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00327-9/fulltext People on reddit love to spread the harmful "You must finish the whole course" misinformation. https://humanmicrobiome.info/antibiotics/
  33. Michael Harrop

    Antibiotics Antibacterials are everywhere: for the sake of our microbiome, we need to control their use (Jan 2025) Microbiotoxicity: A call to arms for cross-sector protection of the human microbiome

    https://theconversation.com/antibacterials-are-everywhere-for-the-sake-of-our-microbiome-we-need-to-control-their-use-247723 https://www.sciencedirect.com/science/article/pii/S0163445325000027
  34. Michael Harrop

    Sharing My Autoimmune Recovery Journey + Solutions for your Gut Health (GAIP diet)

    I've essentially already tried GAIP. I tolerate flax and chia seeds very poorly. It seems plausible that this diet can help clear problematic components for some people. I read his "How not to die" book and liked it. I'm generally a fan of his, but his info on FMT is quite poor and contains...
  35. Michael Harrop

    FMT Microbiota transplantation reduces recurrence of brain disorder in patients with advanced liver disease (Jan 2025, n=60) Microbiota transplant for hepatic encephalopathy in cirrhosis: The THEMATIC trial

    https://www.legacynewspaper.com/study-microbiota-transplantation-reduces-recurrence-of-brain-disorder-in-patients-with-advanced-liver-disease/ https://www.journal-of-hepatology.eu/article/S0168-8278(25)00005-4/fulltext Their donors are awful, but researchers keep using them because of the...
  36. Michael Harrop

    Sharing My Autoimmune Recovery Journey + Solutions for your Gut Health (GAIP diet)

    That's extremely lucky. But your personal experience does not translate to everyone else. I have eaten plant-based diets, 100% raw vegan, 100% raw paleo, etc. If they're not present you can't feed them. Missing Microbes with Dr Martin Blaser (American Society for Microbiology, 2016)...
  37. Michael Harrop

    Sharing My Autoimmune Recovery Journey + Solutions for your Gut Health (GAIP diet)

    This doesn't appear to make sense. Your cure was a temporary elimination diet? Then when you added back the foods without doing anything else, you could tolerate them fine? I also eat based on an elimination diet. It's not a solution, it's a method to prevent the worst symptoms. It doesn't fix...
  38. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I actually contacted Daisy Robinton when she was associated with Harvard. This was a decade ago I think, when I was contacting individuals to ask them to be a stool donor for me. She responded and initially seemed willing but then chickened out. I contacted her more recently after she moved to...
  39. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    This should not be relevant. Patients should be able to advocate for treatment access without having credentials/institutional affiliations. Especially when a ton of scientific evidence is presented. Additionally, there are major deficiencies with "credendials" and "institutions" [1][2][3]. The...
  40. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I did say that to Senator Cassidy's office. I believe it's true too, which is one of the many reasons it seems bizarre that these politicians aren't jumping at the chance to champion this. Marco Rubio is focused on trying to become Secretary of State, but it wouldn't hurt to follow up with his...
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