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  1. Michael Harrop

    Procedure SMT from China (selective microbiota transplantation)

    Could you share more info on SMT? This is not surprising at all, and isn't a reason to opt for SMT instead of FMT. The issue you experienced is due to their donors: https://humanmicrobiome.info/where-to-get-fmt/
  2. Michael Harrop

    Donors Has anyone tried children as stool donors for FMT?

    Yes, many people have used children for FMT with success. There is a bit of info in this thread on that too: https://forum.humanmicrobiome.info/threads/does-stool-donor-sex-and-age-matter-are-there-differences-in-receiving.416/
  3. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    Senator Bill Cassidy and other Republicans have been taking steps to reform NIH since at least 2023: https://www.aip.org/fyi/republicans-push-nih-reform I read his white papers and strongly support his efforts, but it sounds like it's largely up to NIH and RFK/HHS to actually implement the...
  4. Michael Harrop

    Enhancing I figured out my gut biome issue, might explain why FMT's don't take: B12 and folate deficiencies creating an environment that hinders the success of FMT

    What is the reasoning behind "might explain why FMT's don't take"?
  5. Michael Harrop

    Donors Doubts about supposed donor compatibility/matching, signaling, and microbiota depletion

    Engraftment. There are a few threads on donor matching: https://forum.humanmicrobiome.info/forums/fecal-microbiota-transplant-fmt/?prefix_id=66 Here's a summary: https://forum.humanmicrobiome.info/threads/does-stool-donor-sex-and-age-matter-are-there-differences-in-receiving.416/post-1029...
  6. Michael Harrop

    Enhancing Antifreeze in stool/FMT capsules, glycerol vs maltodextrin, -80 (medical freezer) vs -20 (home freezer)

    Closed access: Evaluation of the effects of different formulations of protectants on the preservation of the microbiota in fecal microbiota transplantation (May 2025) https://link.springer.com/article/10.1007/s10123-025-00663-6
  7. Michael Harrop

    Advocacy NIH National Advisory Neurological Disorders and Stroke Council (NANDSC) ME/CFS Research Roadmap Working Group - letter re finalized roadmap

    I attended the MEAction Millions Missing protest outside the Capitol building on May 12, 2025. https://www.meactions.org/millionsmissing25 I contacted the MEAction directors two weeks prior, then spoke to them and the crowd during the protest, and then wrote to them again afterward. I explained...
  8. Michael Harrop

    Donors Thoughts on HumanMicrobes donor problem

    I'm aware. Which is why I said they've been doing a lot of good stuff. That's what I meant. The donors I find have always been available to everyone. And I wasn't speaking about funding, I said "their funders", IE: the patient community. A lot of the most valuable help would be non-monetary...
  9. Michael Harrop

    Procedure Getting blood and stool testing for an FMT donor

    This is covered in the wiki: https://humanmicrobiome.info/fmt/#screening I've done both.
  10. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    1. The difference between the microbiome of the mucosa vs feces. 2. Clearing the mucosa. From the OP: Yes, I'm sure biofilms are an important part of it. https://forum.humanmicrobiome.info/tags/biofilm/. It would be great if we could solve this by taking a biofilm disolver for a week prior to...
  11. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Oh my, you're going down the path of SFBayFMT5 (adding useless, erroneous noise via uninformed opinions, poor reading comprehension, and not taking into account previous discussion/information). I'll save my breath for them then. But you're already wrong since FMT researchers already thought it...
  12. Michael Harrop

    Advocacy NIH National Advisory Neurological Disorders and Stroke Council (NANDSC) ME/CFS Research Roadmap Working Group - letter re finalized roadmap

    https://www.ninds.nih.gov/about-ninds/who-we-are/advisory-council/nandsc-mecfs-research-roadmap-working-group I just reviewed it and sent them an email: You could say this is far too confrontational, but as I've noted on my blog, anything else seems to just get ignored. My attitude is the...
  13. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    From what I understood, your review of the evidence looked at the fecal microbiome vs the mucosal microbiome, which is a different matter. Your linked analysis did not look at layers of the mucosa. I don't recall any studies that have done that either. I think you're confusing two different...
  14. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    I'm not sure where you're getting "zero microbiome" from. I don't think 100% elimination is a goal at all. I agree that it doesn't seem possible. I described the problem in my most recent experience report: So the goal is to remove as much of the bottom layer as possible, including biofilm...
  15. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Both. There are already studies in both. Probably mice then humans. You could and should, but as noted in the OP, a study showed that clearing the mucosa alone was enough for major improvement. I currently think it's the #1 priority, and the most promising, impactful intervention, with FMT being...
  16. Michael Harrop

    Procedure How important is upper FMT timing with meals?

    Try it and let us know. There's evidence for probiotics that they should be taken before or with a meal. It has to do with acid and ph levels. https://humanmicrobiome.info/probiotics/
  17. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    You can read through their reports on this forum, and/or the spreadsheet here: https://www.humanmicrobes.org/orders
  18. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    @PittsburghGutGuy None of that is important. All of it is experimental.
  19. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    @krehorst More details would be useful but you can browse through previous discussions & experiences to understand why this is happening. Your options are: 1. Keep doing it. 2. Find a better donor. 3. Wait till there's a way to clear the existing microbiome.
  20. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    1. Not a deal breaker. 2-3 covered in the wiki https://humanmicrobiome.info/fmt/
  21. Michael Harrop

    Enhancing Ozone therapy to clear the existing microbiome and biofilms before FMT | with veterinary Dr. Margo Roman

    A 5-year-old video. She seems knowledgeable. She does FMT for/with animals. She stresses the importance of donor quality. I can't recall seeing any studies testing ozone therapy prior to FMT. Maybe because of the quote below where the FDA says it's only toxic and has no benefit. It doesn't...
  22. Michael Harrop

    Enhancing Experiment: Fasting during FMT for increased effect

    I stopped doing bowel prep and fasting because it didn't seem to help. It sounds like you know the donor personally? Was this the first time you used this donor? You only did one lower-route FMT from this donor?
  23. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    NIH Office of Human Subjects Research Protections I was waiting to see if NIH would respond. It's been nearly a month and no response. I contacted the IRB email listed here: https://irbo.nih.gov/confluence/display/ohsrp/Home I don't think that particular group deserves to be singled out any...
  24. Michael Harrop

    Sources Comparing commercial FMT providers

    @SFBayFMT5 PM'd me with some persistent misconceptions of how HM compares to other providers. Much of this is covered here: https://humanmicrobiome.info/where-to-get-fmt/ https://www.humanmicrobes.org/...
  25. Michael Harrop

    Outcomes Body odor changes after FMT?

    Based on my and others' experiences, picking up a bad BO seems to mostly only happen if you use a bad donor. However, if you have bad BO to start with, a good donor can certainly reduce it.
  26. Michael Harrop

    Sources Comparing commercial FMT providers

    That's not true though. This is such a fundamental lack of understanding of how evidence and clinical trials work. It's like saying you can't compare clinical trials without having the exact same patients participate in both trials. If other providers systematically tracked & reported their...
  27. Michael Harrop

    Sources Comparing commercial FMT providers

    I agree, and it's something I've criticized people for for many years. By not writing up public, detailed reports of their experiences, they're doing a disservice to themselves and everyone else by not allowing accurate assessments of available sources. But as is, you can and should pretty much...
  28. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    It's done, it's just not necessarily needed. I've seen occasional complaints about "poop burps". Some people have also not wanted to see poop in the capsules at all due to personal revulsion. So there are a few additional reasons. It is still up for debate I think, but at the end of the...
  29. Michael Harrop

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    This is not correct. https://humanmicrobiome.info/fmt/#upper-vs-lower-routes In the ASU study they drank the liquid straight. Why do you say this? They're chowing down on whole stools pooped out by the other mice. That seems like a larger dose if anything. But certainly a longer dosing period...
  30. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    You'd have to look up various enteric-coated capsules and read their claims and perhaps contact the manufacturer.
  31. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    Glelatin won't do it. One recipient was experimenting with various coatings & combinations but they haven't posted it publicly. That's not the only method in the wiki.
  32. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    Generally, that's correct. There appears to be a benefit if you can coat the whole colon. For instance, this is where colonization resistance comes into play. If you can directly coat an area with the new microbes, that's likely to have a stronger effect vs them having to migrate on their own...
  33. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    HHS Office for Human Research Protections (OHRP) I submitted a complaint via https://oashsps.my.site.com/ohrpwebforms/s/complaint-web-form. The result: Case closed, we don't care, you have to do a ton of work for us, it's not our job to prevent this harm to patients. The first response: My...
  34. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    NIH would have to make the required changes first. NIH does not do that kind of thing currently.
  35. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    Everything that's happened over the past few months, plus these recent studies [1][2][3], was the catalyst for this post. And despite all this, they have the audacity to constantly write stuff like: "Don't take things into your own hands; leave everything up to us. We're the only ones competent...
  36. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    Since my first letters in 2018 to both the NIH and FDA, nothing has changed. Hundreds of millions of dollars continue to be wasted on FMT (fecal microbiota transplant) clinical trials with low-quality donors, patients continue to be harmed, and safe & effective FMT continues to be unavailable...
  37. Michael Harrop

    Outcomes Please help - anxiety/panic after FMT+yellow stool

    You should format that properly with paragraphs to make it easier to read -- if you want people to read it and help. Some people get lucky and don't get worse from bad donors. There are also people who lie and astroturf to promote certain sources. "A healthy, slim woman, with no mental...
  38. Michael Harrop

    Procedure Effect on FMT storage long term in -20c freezer

    A regular home freezer. I updated the FAQ.
  39. Michael Harrop

    Procedure Is there any chance double layered crapsules don't open at all and pass through whole?

    FMT is a serious undertaking and it appears that you haven't reviewed the wiki at all. You really need to do that if you don't want to end up worse off. You can also do a "ctrl+f" in this category (/forums/fecal-microbiota-transplant-fmt/) for "sibo" and see other discussions. You can also...
  40. Michael Harrop

    Autologous Autologous type-3 FMT (dark brown), Floraphage

    What SFBayFMT5 said is correct, but SFBayFMT5 misunderstood what bizzoc was asking, and thus the statement "this concept is correct" is false.
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