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  1. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    The OP covered a unique method that one study used for diabetes patients. The next comment covers the possibility of using NAC. A colon cleanse doesn't seem sufficient https://humanmicrobiome.info/fmt/#before-the-procedure.
  2. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Related threads: Improve FMT effectiveness with mucus and biofilm dissolver? N-acetyl cysteine (NAC) FMT engraftment Strategies To Increase The Effectiveness Of FMT
  3. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    I posted about this a few years ago elsewhere and I'm copying all the info here for easy discussion. "While fecal microbiota is partially normalized by extended co-housing, mucosal communities associated with the proximal colon and terminal ileum remain stable and distinct". Comparison of...
  4. Michael Harrop

    Improve FMT effectiveness with mucus and biofilm dissolver? N-acetyl cysteine (NAC)

    I remember reading something on this topic but my memory is terrible right now and I can't remember exactly what it was. But this seems like something that should be tested in animal models first. I covered the possibility of a "mucosal microbiota transplant" in my FMT roadmap proposal. I...
  5. Michael Harrop

    Capsules from HMorg--what type? Delayed release, enteric coated.

    Delayed release is generally similar to enteric coated, but some types of material that capsules can be made from are acid-resistant and delayed release without requiring an enteric coating. Some of the enteric coating ingredients are possibly not the most healthy. I've tried delayed...
  6. Michael Harrop

    Considering a 5 year old girl to be a FMT donor for a 10 year old girl who has some health problems

    Make sure you do adequate learning first. Many people use donors they think are ideal and get worse because they didn't properly understand what makes an ideal stool donor. Stool type/characteristics seem to be one of the more important aspects. You can start here...
  7. Michael Harrop

    Donors' lab test results for humanmicrobes.org?

    There's a donor list with all the info on each donor, including the test results. You can email Human Microbes directly for that info.
  8. Michael Harrop

    FMT engraftment

    There is some coverage of this in the FMT wiki page under "Outcomes" https://humanmicrobiome.info/fmt/#outcomes. It includes this recent thread with discussion & links: https://forum.humanmicrobiome.info/threads/variability-of-strain-engraftment-and-predictability-of-microbiome-com.325/post-721...
  9. Michael Harrop

    HumanMicrobes.org recipient IDs

    Alright, this is going to be difficult, but I'll try to keep the current date/number format but keep it consistent per recipient across multiple donors.
  10. Michael Harrop

    HumanMicrobes.org recipient IDs

    Yeah, recipients seemed to want more anonymity so I changed how they're identified. They are welcome to reference their previous results entry with other donors. One recipient did that. If you have a format suggestion for creating unique IDs that are also completely anonymous, let me know. I'm...
  11. Michael Harrop

    FMT for candida albicans overgrowth?

    Citation needed. There's a citation in the link I provided to the contrary: "High gut Candida before FMT is associated with clinical response in ulcerative colitis" (Apr 2020, n=39(?)) https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30170-0
  12. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Lots of people in these categories have applied to HM. I don't have a specific way to target any groups though. I tried to contact top Crossfit athletes and they didn't respond. That would be great! Please do. But keep in mind that my health is currently too poor to go on any podcasts. However...
  13. Michael Harrop

    FMT Using Animal Feces; FMT from animals

    Yes, there are various historical reports of people eating animal feces with successful health benefits, but I see that wikipedia says it's likely a myth. It's something that I and many others have considered due to desperation and no better options. Some people have even tried it with success...
  14. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    I've already found 3 highly effective donors in the US. You're right of course about those alarming trends that are making this much harder. https://forum.humanmicrobiome.info/threads/while-antibiotic-resistance-gets-all-the-attention-the-damage-being-do.50/ I have no way to do this, but HM...
  15. Michael Harrop

    Strategies To Increase The Effectiveness Of FMT

    Disagree. C. diff is uniquely easier to cure because it's one known microbe, and the microbes needed to suppress it are more common. There is plenty of evidence supporting FMT for many chronic conditions https://humanmicrobiome.info/intro/, but it requires higher donor quality. The...
  16. Michael Harrop

    FMT for candida albicans overgrowth?

    There is one case report in the wiki https://humanmicrobiome.info/candida/#fmt.
  17. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Yes, it's briefly discussed here https://forum.humanmicrobiome.info/threads/chlorine-in-treated-drinking-water.320/. I don't think they're promising, and even if they were, the logistics would be difficult.
  18. Michael Harrop

    FMT and male pattern baldness [hair loss, alopecia]

    It is merely one of dozens of people haphazardly going about FMT without adequate learning, and thus using a low-quality donor that they mistakenly thought was a good donor. There is no good evidence for sex-matching, and universal donors are the norm. So you found a clinic that is willing to...
  19. Michael Harrop

    FMT and male pattern baldness [hair loss, alopecia]

    That assurance is meaningless. Review this https://humanmicrobiome.info/where-to-get-fmt/ thoroughly, including the list of questions to ask them. There's a wiki section on hair loss https://humanmicrobiome.info/intro/#alopecia-hair-loss which I'll add to now. I don't think that makes sense...
  20. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    In large part, it's still unknown how these microbes get passed down generationally, and how exactly the infant microbiome develops https://humanmicrobiome.info/origins/, but with adults, FMT appears to be the only way. Better for its own thread, but from...
  21. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Any intervention other than FMT is extremely limited since they will not add host-native microbes. So while there are a number of ways (diet, lifestyle) one can improve their health and gut microbiome, FMT is the only intervention that would be able to significantly "upgrade" a stool donor. This...
  22. Michael Harrop

    Purety Clinic experience?

    $600 per enema, 6x the cost of other sources. Making the "don't lose hope if you think you'll never be able to afford FMT" comment seem odd. This is not a valid notion based on any evidence I've seen. I'm doubtful that you understood the important factors to consider, since nothing you've said...
  23. Michael Harrop

    Is human microbes getting shut down?

    This may be an opportunity to get support and continue as a clinical trial: fas.org (Federation of American Scientists) Day One Project policy proposal for FMT Please share your feedback and ideas.
  24. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    The Challenge: What is the pressing issue that society is facing? (50–100 words) Rampant and increasing chronic disease. https://forum.humanmicrobiome.info/threads/chronic-disease-and-general-poor-health-have-been-drastically-increasi.44/ The Opportunity: What is your idea for solving that...
  25. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    Katie McCaskey wrote to me on Mastodon: I took a look at the link and I'm working on writing up something about FMT/Human Microbes to submit, but I see "What are specific steps the federal government can take to implement your solution?". I'm doubtful that the feds are the best option to...
  26. Michael Harrop

    Is human microbes getting shut down?

    Thank you Joseph! Testing stool samples is covered in the most recent blog, and the wiki.
  27. Michael Harrop

    Is human microbes getting shut down?

    FDA Enforcement Discretion and EUAs (Emergency Use Authorization): https://www.fdaimports.com/the-difference-between-fda-enforcement-discretion-and-euas/ https://www.thehartford.com/insights/life-science/enforcement-discretion-for-life-science-companies FMT, and the patient need for it...
  28. Michael Harrop

    Is human microbes getting shut down?

    This is irrelevant/non sequitur. Relatedly, I think the only person in the world that comes close to matching my knowledge of FMT is another patient. There is no one in the world I would look to for advice on FMT, but his input can be useful. This reflects the nature and status of FMT. Stool...
  29. Michael Harrop

    Is human microbes getting shut down?

    I will attend the meeting and see what happens. I'm currently still emailing the 1.2 million donor applicants. I'm about halfway through and so far no one seems to care. So things are not looking good. If you are able to get in touch with Dr. Jason Hawrelak and let him know about this project...
  30. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    A marketer shared some insight/advice with me: I agree. I think there is quite an incentive for well-off people (such as world-class athletes) to become stool donors in order to say "I was the source of this cure for billions of people". Unfortunately, that hasn't really panned out. I think it...
  31. Michael Harrop

    Is human microbes getting shut down?

    I got a letter back from the FDA today requesting a Zoom meeting. But it doesn't sound like they're interested in anything I have to say, nor are they interested in making any changes to FMT regulation to allow a project like Human Microbes to exist. Their letter only states that we haven't made...
  32. Michael Harrop

    Attractiveness, facial features, health & development, and FMT donor selection. (Jul 2019)

    A very rough estimate is around 30 years old. Discussion of donor criteria would go better in https://forum.humanmicrobiome.info/threads/the-evidence-and-rationale-supporting-our-stool-donor-criteria-2022-hu.131/.
  33. Michael Harrop

    Is human microbes getting shut down?

    This Expanded Access program https://www.fda.gov/news-events/expanded-access/expanded-access-information-patients that allows patients to try non-licensed drugs seems like it should make it possible for this project to continue. The criteria seem a tad burdensome: Other than that, most of...
  34. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Indeed. It is strange and frustrating. It makes me feel like it's a waste of time and it makes me feel like giving up all the time. Many of the 23k came from targeted outreach to hundreds of top college and professional athletes. The current #1 active donor is one of those athletes. In...
  35. Michael Harrop

    Is human microbes getting shut down?

    Top young athletes. People like Mbappe, Haaland, Virgil van Dijk, Mohamed Salah, Giannis Antetokounmpo, Ja Morant, etc. Pretty much, we can't indicate that we're supplying stool for FMT. There are already two such videos on the website and YT channel. I would have to completely redo them...
  36. Michael Harrop

    Is human microbes getting shut down?

    As I said, the videos lead them to our website, but it's the FMT content on our website that convinces them it's real and worth signing up for. Those kinds of side hustle videos don't even seem super useful. They've doubled the number of applicants to over a million now, without resulting in a...
  37. Michael Harrop

    Is human microbes getting shut down?

    From what I read, it's possible but up to FDA discretion. The ones I saw showcase our website, which clearly explains the need and importance of stool donors for FMT. The videos lead them to our website, but it's the FMT content on our website that convinces them it's real and worth signing up...
  38. Michael Harrop

    Is human microbes getting shut down?

    Why is that? I don't think we'll get to that point if we have to remove all mention of FMT from the website. I would say that most of the info on social media these days is terrible and untrustworthy. People do not behave rationally and spread useful information. HMorg is already a massive and...
  39. Michael Harrop

    Is human microbes getting shut down?

    Donor quality is not going to increase on its own. I recently posted to social media https://mastodon.social/@michaelharrop/111839584865293858 that I've received over a million applicants at this point and still haven't found one that meets the ideal criteria. Donor applicants are finding us via...
  40. Michael Harrop

    Is human microbes getting shut down?

    It is true that I could drastically change the wording on the website to remove all mention of FMT, and that would keep the FDA from getting involved. That would make the website unfindable for most people and it would completely destroy one of the main goals of HumanMicrobes.org -- finding...
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