I've been doing a lot of research on FMT and one of the questions I ask myself is why is it effective for some people and not others. I was watching a video with Will Bulsiewicz, MD and he was talking about the difference in efficacy for acute vs. chronic conditions:
https://www.youtube.com/watch?v=EABZqi3HtRM (1:46:33 - 1:53:35)
FMT seems to be effective for acute conditions (e.g. C. difficile) but not for chronic conditions. I know you've tried multiple FMTs and you're still struggling with health issues. The question is why are the microbes in the FMT not setting up shop in your gut.
I came across a video with Lucy Mailing, PhD about gut dysbiosis:
https://www.youtube.com/watch?v=s2LIHwicPQk
She makes a distinction between obligate anaerobes (OA) and facultative anaerobes (FA). OA can only grow in an environment that has little oxygen and are considered beneficial. FA can grow in an environment with or without oxygen and are considered pathogens. The colon of a healthy human is normally devoid of oxygen which promotes the growth of OA and inhibits the growth of FA. A simple formula for heath would be:
Eubiosis = OA > FA
One way to measure a healthy colon would be the production of metabolites (e.g. butyrate).
Conversely, the colon of a sick person would have oxygen present which would promote the growth of FA and inhibit the growth of OA. So, a formula for disease would be:
Dysbiosis = FA > OA
One explanation for why the FMT is not working is because you have oxygen in your colon which is preventing the beneficial microbes from growing. At 36:49, Lucy makes a number of suggestions to reduce oxygen in the colon. Have you tried supplementing with butyrate while doing an FMT? Have you tried a ketogenic diet? Fasting?
I recently spoke to Lucy and she recommended a product called ThaenaBiotic:
https://thaena.com/pages/faqs
It's basically a sterilized FMT so you get some of the benefits of FMT (e.g. postbiotics) with none of the risks. An interesting experiment would be to take ThaenaBiotic and an FMT together.
https://www.youtube.com/watch?v=EABZqi3HtRM (1:46:33 - 1:53:35)
FMT seems to be effective for acute conditions (e.g. C. difficile) but not for chronic conditions. I know you've tried multiple FMTs and you're still struggling with health issues. The question is why are the microbes in the FMT not setting up shop in your gut.
I came across a video with Lucy Mailing, PhD about gut dysbiosis:
https://www.youtube.com/watch?v=s2LIHwicPQk
She makes a distinction between obligate anaerobes (OA) and facultative anaerobes (FA). OA can only grow in an environment that has little oxygen and are considered beneficial. FA can grow in an environment with or without oxygen and are considered pathogens. The colon of a healthy human is normally devoid of oxygen which promotes the growth of OA and inhibits the growth of FA. A simple formula for heath would be:
Eubiosis = OA > FA
One way to measure a healthy colon would be the production of metabolites (e.g. butyrate).
Conversely, the colon of a sick person would have oxygen present which would promote the growth of FA and inhibit the growth of OA. So, a formula for disease would be:
Dysbiosis = FA > OA
One explanation for why the FMT is not working is because you have oxygen in your colon which is preventing the beneficial microbes from growing. At 36:49, Lucy makes a number of suggestions to reduce oxygen in the colon. Have you tried supplementing with butyrate while doing an FMT? Have you tried a ketogenic diet? Fasting?
I recently spoke to Lucy and she recommended a product called ThaenaBiotic:
https://thaena.com/pages/faqs
It's basically a sterilized FMT so you get some of the benefits of FMT (e.g. postbiotics) with none of the risks. An interesting experiment would be to take ThaenaBiotic and an FMT together.
