New Company www.MyGutly.com for Personalized Fecal Transplantation FMT

[MyGutly]

I wanted to share a new company I just launched in the Microbiome and Personalized Fecal Transplantation space.

My name is Kyle Cetrulo and I am the Founder and CEO of MyGutly, the world’s first personalized fecal transplantation company. https://mygutly.com/

The concept powering MyGutly is that during a time of optimal health the composition of the gut microbiome is collected via a stool sample and is processed and stored in capsules. The capsules are readily available for future use to restore the gut microbiome of that individual to the state at which it was collected.

There are numerous ways to disturb your gut microbiome such as from a round of antibiotics, chemotherapy or simply eating foods that don’t agree with your body. However, there are very few resources to restore your gut microbiome to a healthy state. Diet and probiotics alone take multiple months to restore your gut microbiome. In recent studies, personalized fecal transplantation has shown the ability to restore the gut microbiome to 75% of the collected composition in about a week. (1)

I really think that for some of you our service will provide a new strategy to help with your illness.

To learn more, please call or schedule a time to speak with this link.

https://calendly.com/kyle-mygutly


Sincerely,


Kyle Cetrulo

Founder/CEO

[email protected]

16176109000







Reference:

[1] https://pubmed.ncbi.nlm.nih.gov/30193113/

 

[Michael Harrop]

Info on autologous FMT: https://humanmicrobiome.info/faq/#what-about-autologous-fmt

 

[Sift0593]

Although it doesn't seem to work right now (1), maybe it's worth trying to make a backup if it's cheap.

I'd like to see the collection procedure and how to minimise oxygen exposure. I'd expect it to be better to freeze it at home ASAP than benefit from freezing at a lower temperature with more time in the post for oxygen exposure. Then again, it only takes a moment of oxygen.

Perhaps particular foods could be eaten for a few days beforehand to improve the process?


https://humanmicrobiome.info/fmt/#autologous
[1] https://forum.humanmicrobiome.info/threads/safety-and-tolerability-of-frozen-capsulized-autologous-faecal-microbi.170/

edit: Just noticed all the references at the bottom of the mygutly page; far more optimistic. I'll post them here for reference. I'll have to read though them all and try to summerise later. We'll probably find that the devil's in the details.




Autologous Fecal Transplant (disambiguation: heterologous = not from the self, a-FMT is more commonly used abbreviation that aFMT)

1. Suez J, Zmora N, Zilberman-Schapira G, Mor U, Dori-Bachash M, Bashiardes S, Zur M, Regev-Lehavi D, Ben-Zeev Brik R, Federici S, Horn M, Cohen Y, Moor AE, Zeevi D, Korem T, Kotler E, Harmelin A, Itzkovitz S, Maharshak N, Shibolet O, Pevsner-Fischer M, Shapiro H, Sharon I, Halpern Z, Segal E, Elinav E. Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT. Cell. 2018 Sep 6;174(6):1406-1423.e16. doi: 10.1016/j.cell.2018.08.047. PMID: 30193113.
https://pubmed.ncbi.nlm.nih.gov/30193113/
2. Bulow C, Langdon A, Hink T, Wallace MA, Reske KA, Patel S, Sun X, Seiler S, Jones S, Kwon JH, Burnham CAD, Dantas G, Dubberke ER. Impact of Amoxicillin-Clavulanate followed by Autologous Fecal Microbiota Transplantation on Fecal Microbiome Structure and Metabolic Potential. mSphere [Internet]. American Society for Microbiology; 2018 Dec 26;3(6). Available from: https://doi.org/10.1128/mspheredirect.00588-18
https://pubmed.ncbi.nlm.nih.gov/30463925/
3. Rinott E, Youngster I, Meir AY, Tsaban G, Kaplan A, Zelicha H, Rubin EB, Koren O, Shai I. Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions. European Journal of Internal Medicine [Internet]. Elsevier BV; 2021 Oct 1;92:17– 23. Available from: https://doi.org/10.1016/j.ejim.2021.03.038
https://www.sciencedirect.com/science/article/pii/S0953620521001102
4. Basson AR, Zhou Y, Seo BJ, Rodriguez-Palacios A, Cominelli F. Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease. Translational Research [Internet]. Elsevier BV; 2020 Dec 1;226:1–11. Available from: https://doi.org/10.1016/j.trsl.2020.05.008
https://pubmed.ncbi.nlm.nih.gov/32585148/
5. Bulow C, Langdon A, Hink T, Wallace MA, Reske KA, Patel S, Sun X, Seiler S, Jones S, Kwon JH, Burnham CAD, Dantas G, Dubberke ER. Impact of Amoxicillin-Clavulanate followed by Autologous Fecal Microbiota Transplantation on Fecal Microbiome Structure and Metabolic Potential. mSphere [Internet]. American Society for Microbiology; 2018 Dec 26;3(6). Available from: https://doi.org/10.1128/mspheredirect.00588-18
https://pubmed.ncbi.nlm.nih.gov/30463925/
6. Taur Y, Coyte KZ, Schluter J, Robilotti E, Figueroa C, Gjonbalaj M, Littmann ER, Ling L, Miller L, Gyaltshen Y, Fontana E, Morjaria S, Gyurkocza B, Perales MA, Castro-Malaspina H, Tamari R, Ponce DM, Koehne G, Barker JN, Jakubowski AA, Papadopoulos EB, Dahi PB, Sauter CS, Shaffer BL, Young JB, Peled JU, Meagher RB, Jenq RR, Van Den Brink MRM, Giralt S, Pamer EG, Xavier JB. Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Science Translational Medicine [Internet]. American Association for the Advancement of Science; 2018 Sep 26;10(460). Available from:
https://doi.org/10.1126/scitranslmed.aap9489
https://www.science.org/doi/abs/10.1126/scitranslmed.aap9489

(edit, reducing less relevant citations)

Capsules as Effective Delivery Method
39. Ramai D, Zakhia K, Fields P, Ofosu A, Patel G, Shahnazarian V, Lai JR, Dhaliwal A, Reddy M, Chang S. Fecal Microbiota Transplantation (FMT) with Colonoscopy Is Superior to Enema and Nasogastric Tube While Comparable to Capsule for the Treatment of Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis. Digestive Diseases and Sciences [Internet]. Springer Science+Business Media; 2020 Mar 12;66(2):369–380. Available from: https://doi.org/10.1007/s10620-020-06185-7 https://pubmed.ncbi.nlm.nih.gov/32166622/

"The random effects of pooled FMT cure rates were colonoscopy 94.8% (CI 92.4-96.8%; I2 15.6%), capsule 92.1% (CI 88.6-95.0%; I2 7.1%), enema 87.2% (CI 83.4-90.5%; I2 0%), and NGT/NDT 78.1% (CI 71.6-84.1%; I2 0%)."