Study Nanoplastics promote conditions for Parkinson's across various lab models (Nov 2023) Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation

Michael Harrop

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https://medicalxpress.com/news/2023-11-nanoplastics-conditions-parkinson-lab.html
https://www.science.org/doi/10.1126/sciadv.adi8716

Abstract​

Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here, we find that anionic nanoplastic contaminants potently precipitate the formation and propagation of α-synuclein protein fibrils through a high-affinity interaction with the amphipathic and non-amyloid component (NAC) domains in α-synuclein.

Nanoplastics can internalize in neurons through clathrin-dependent endocytosis, causing a mild lysosomal impairment that slows the degradation of aggregated α-synuclein. In mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra.

These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson’s disease and related dementias.
 
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