Lauren Petersen's DIY FMT from an elite cyclist for chronic Lyme disease and CFS (chronic fatigue syndrome, fecal microbiota transplant, 2017)

Michael Harrop

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The madwoman behind “poop doping” is Lauren Petersen, a postdoctoral microbiologist at the Jackson Laboratory for Genomic Medicine. Petersen has been racing bikes all her life, but as she told The Scientist earlier this month, she’s struggled with chronic Lyme disease since her teen years. She finally rid herself of the disease in 2013, but the intense course of antibiotics she took had ravaged her system and left her with chronic fatigue and stomach problems.

Eventually, she learned that her microbiome (the colony of microbes in her body) was dangerously unbalanced and was not functioning as it should. She was not breaking down any food, and she learned that she was not eligible for a potentially beneficial fecal transplant. So she simply did one herself. As she said, it was a fairly dangerous DIY procedure and it wasn’t fun, but it worked better than she thought it could:

In February 2014, with the support of her family, she recruited a donor and did it herself. “I just did it at home. It’s not fun, but it’s pretty basic. It costs like six bucks to do.” (The $6 being for the drugstore enema kit.)

The do-it-yourself solution worked. “Within two months I was a new person,” Petersen says. “I had no more fatigue. I could ride my bike hard three days in a row, no problem.” She started racing four months after her fecal transplant, and was winning races at the pro level soon after that. “Everything changed,” Petersen says.

Petersen’s donor was a fellow elite cyclist, and after analyzing the sample and those of other riders, she discovered an unusually high prevalence of the bacterium Prevotella, which helps synthesize amino acids that help in muscle recovery. Petersen’s analysis of her friends’ craps also showed an abundance of M. smithii, which performs a complementary function.

Petersen is now studying the contents of several more cyclists’ butts and trying to determine what specific role the two bacteria play in a complicated environment with hundreds of variables.

Deadspin reached out to Petersen about the potential hazards of poop doping, and she said that the need for rigorous testing means it will be years before anyone can poop dope. Her team is working on the best way to grow Prevotella, and they will soon move to testing on mice.
 
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