High Zonulin + Strep. Suggestions?

Vitality

New member
Joined
Nov 28, 2025
Messages
2
Questions / Looking for Success Stories
  • Has anyone successfully lowered high zonulin levels?
  • How long did it take to notice improvements?
  • Did weight loss or sleep improve once zonulin came down?
  • Any advice for safe fiber increase while healing leaky gut?
  • Will adjust my diet and ordered a few supplements. Working with a functional practitioner but don’t see her til Jan.
Key results from GI MAP:

Zonulin243.3 ng/g< 175HIGH
Secretory IgA280510–2010LOW
Streptococcus spp.8.45e3< 1.00e3HIGH dysbiosis / inflammation

Ordered:
  1. L-Glutamine
  2. Zinc Carnosine
  3. IgG (SBI Protect / Mega IgG)
  4. Will add Bone Broth – to take daily
  5. Collage Peptides/Protein powder
  6. Psyllium Husk
  7. Sunfiber
  8. L. Reuteri
 
While I'm sure there are people in the world who have benefitted from this sort of approach, I suspect it will be difficult to find people like that here. People who end up trying FMT on their own, or else have FMT performed by a doctor and then seek it out again due to highly favorable results, are likely to be those for whom more nutritional approaches fail, or at least don't provide more than the most temporary improvement.

Those approaches you listed, aside from the L reuteri, which is just ONE species of bacterium, don't introduce any new organisms into your body that don't already exist there. Some people presumably already have SOME of everything they need, and for some of them simply feeding the right bugs brings significant changes, but that isn't the case for everyone.
 
While I'm sure there are people in the world who have benefitted from this sort of approach, I suspect it will be difficult to find people like that here. People who end up trying FMT on their own, or else have FMT performed by a doctor and then seek it out again due to highly favorable results, are likely to be those for whom more nutritional approaches fail, or at least don't provide more than the most temporary improvement.

Those approaches you listed, aside from the L reuteri, which is just ONE species of bacterium, don't introduce any new organisms into your body that don't already exist there. Some people presumably already have SOME of everything they need, and for some of them simply feeding the right bugs brings significant changes, but that isn't the case for everyone.
Thanks, agree and I’m just starting to learn more. Not sure what will help but will try what I can now.
 
What's more useful is an overall picture of your gut, not self-induced tunnel vision on red text. Many strains of Strep. can protect themselves against IgG, and enjoy the presence of proteins. You may have to overwhelm them with IgG to have any impact on them, but this is likely not the best approach. Reuteri is more effective at producing antibiotics when coupled with certain nutrients (e.g. B vitamins, like B12), but you'll need to consume over 25 billion CFU.

Weight gain/loss has more to do with microbiome composition, and Reuteri can go either way, depending on what microbes it impacts. Relative abundance and how diet impacts relative abundance depends entirely on microbiome composition. A better approach isn't trying to kill off specific microbes, but to improve the relative abundance of beneficial microbes. In the worst case, your composition may be of such where diet and lifestyle has little to no impact on abundance.
 
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