High blood pressure, heart attacks linked to common preservatives in food (May 2026, n=112,395) Preservative food additives, hypertension, and cardiovascular diseases: the NutriNet-Santé study Study 

Michael Harrop

Well-known member
Joined
Jul 6, 2023
Messages
1,550
Location
USA

While the findings of the new research are observational and cannot prove cause and effect, the study did a good job of controlling for other factors that may influence health, such as age, body mass index or BMI, smoking, physical activity and diet in general

“Although they cannot prove causation, there are signals in the results that warrant further investigation.”

“This is one of the first large studies to look at individual preservatives rather than treating ultra-processed foods as a single category,”

To be in the study, each participant tracks every bite of their food and drink by brand name for three days every six months. Researchers then use a database of product ingredients to identify common preservatives and compare levels of consumption over years with medical data stored in the French national health care system.

Researchers did a deep dive on 17 preservatives consumed by at least 10% of the participants and found eight were associated with higher blood pressure over the next decade. Three of those — potassium sorbate, potassium metabisulphite and sodium nitrite — are “non-antioxidant” preservatives, which means they kill bacteria, molds and yeast that spoil foods.

The remaining preservatives linked to high blood pressure in the study — ascorbic acid, sodium ascorbate, sodium erythorbate, citric acid and extracts of rosemary — are so-called natural “antioxidant” preservatives, used to reduce oxidation that turns foods brown and rancid.

Ascorbic acid, or vitamin C, was also specifically linked to cardiovascular disease, the study found.

Abstract​


Background and Aims
Experimental studies suggest that some preservative food additives may exert adverse cardiovascular effects, yet human data are lacking. The associations between exposure to these compounds and incidence of hypertension and cardiovascular diseases (CVD) were investigated in the NutriNet-Santé cohort (France, 2009–2024).

Methods
Dietary intakes were assessed using repeated 24-h dietary records (up to 96), including commercial brands. Exposure to food additives was evaluated through multiple composition databases and ad hoc laboratory assays in food matrices. Associations between cumulative time-dependent exposures to preservative food additives during follow-up and outcomes were characterized using multi-adjusted Cox models.

Results
Overall, 112 395 participants were included (78.7% women, mean age 42.8 ± 14.7 years) with a median follow-up of 7.9 years. The sum of total preservatives encompassed 58 substances consumed by at least one participant. Total non-antioxidant preservatives were positively associated with higher incidences of hypertension [n = 5544; hazard ratio (HR) higher vs. lower consumers: 1.29, 95% confidence interval (CI) 1.20–1.39] and CVD (n = 2450; HR 1.16, 95% CI 1.04–1.29), while total antioxidant preservatives were associated with higher incidence of hypertension (HR 1.22, 95% CI 1.13–1.31). Out of the 17 individual preservative food additives consumed by at least 10% of the study population, eight were associated with higher incidence of hypertension and one with higher incidence of CVD, after multiple test correction.

Conclusions
Multiple associations between exposure to preservative food additives widely used in industrial foods and higher incidence of hypertension or CVD were observed in this large prospective cohort. Experimental research is needed to gain insight into underlying mechanisms. If confirmed, these new data call for the re-evaluation of regulations governing the use of these additives to improve consumer protection.
 
Format correct?
  1. Yes
Back
Top Bottom