Other Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization (Mar 2024) "We provided compelling evidence that specific gut microbiotas play an important role in cognitive performance"

Michael Harrop

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https://www.sciencedirect.com/science/article/abs/pii/S0165032724003987

Highlights​

  • A bidirectional two-sample MR analysis was performed to explore the causal effect between gut microbiota and cognitive performance.
  • IVW analysis showed that four gut microbiotas impaired cognitive performance.
  • Two families and six genera of gut microbiotas had protective effects on cognitive performance.
  • We provided compelling evidence that specific gut microbiotas play an important role in cognitive performance.

Abstract​

Purpose​

Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain.

Methods​

A two-sample Mendelian randomization (MR) study used SNPs linked to gut microbiota (n = 18,340) and cognitive performance (n = 257,841) from recent GWAS data. Inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were employed. Heterogeneity was assessed via Cochran's Q test for IVW. Results were shown with funnel plots. Outliers were detected through leave-one-out method. MR-PRESSO and MR-Egger intercept tests were conducted to address horizontal pleiotropy influence.

Limitations​

Limited to European populations, generic level, and potential confounding factors.

Results​

IVW analysis revealed detrimental effects on cognitive perfmance associated with the presence of genus Blautia (P = 0.013, 0.966[0.940–0.993]), Catenibacterium (P = 0.035, 0.977[0.956–0.998]), Oxalobacter (P = 0.043, 0.979[0.960–0.999]). Roseburia (P < 0.001, 0.935[0.906–0.965]), in particular, remained strongly negatively associated with cognitive performance after Bonferroni correction. Conversely, families including Bacteroidaceae (P = 0.043, 1.040[1.001–1.081]), Rikenellaceae (P = 0.047, 1.026[1.000–1.053]), along with genera including Paraprevotella (P = 0.044, 1.020[1.001–1.039]), Ruminococcus torques group (P = 0.016, 1.062[1.011–1.115]), Bacteroides (P = 0.043, 1.040[1.001–1.081]), Dialister (P = 0.027, 1.039[1.004–1.074]), Paraprevotella (P = 0.044, 1.020[1.001–1.039]) and Ruminococcaceae UCG003 (P = 0.007, 1.040[1.011–1.070]) had a protective effect on cognitive performance.

Conclusions​

Our results suggest that interventions targeting specific gut microbiota may offer a promising avenue for improving cognitive function in diseased populations. The practical application of these findings has the potential to enhance cognitive performance, thereby improving overall quality of life.
 
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'Fluffanutter',....., can't say I've heard that term before:) A definition would be a welcome distraction.
 
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