FMT as supportive treatment for Anorexia Nervosa.

[GutEcologist]

Has anybody done this? And what is their experience? It makes sense to replenish the bacterial toolbox as you are returning to varied and more complex foodstuffs.

https://www.clinicaltrials.gov/search?cond=Anorexia Nervosa&term=FMT

 

[Michael Harrop]

Indeed it makes sense. I'll add an "anorexia" section to the Obesity page https://humanmicrobiome.info/obesity/

Here's the info I have:

Review, Jan 2019: A new review calls for the gut microbiome to be considered as part of standard nutritional rehabilitation for anorexia nervosa. The gut microbiome in anorexia nervosa: relevance for nutritional rehabilitation https://www.gutmicrobiotaforhealth.com/en/a-new-review-calls-for-the-gut-microbiome-to-be-considered-as-part-of-standard-nutritional-rehabilitation-for-anorexia-nervosa/ - https://link.springer.com/article/10.1007/s00213-018-5159-2

Review, Feb 2019: Can Gut Microbiota and Lifestyle Help Us in the Handling of Anorexia Nervosa Patients? https://www.mdpi.com/2076-2607/7/2/58

Review, Feb 2019: The Impact of Starvation on the Microbiome and Gut-Brain Interaction in Anorexia Nervosa https://www.frontiersin.org/articles/10.3389/fendo.2019.00041/full

The gut microbiome derived from anorexia nervosa patients impairs weight gain and behavioral performance in female mice (Aug 2019) https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/en.2019-00408/5554100 "decreased appetite as well as the capacity to convert ingested food to unit of body substance may contribute to poor weight gain"


Conflicting data:

Gut microbial communities from patients with anorexia nervosa do not influence body weight in recipient germ-free mice (Mar 2021) https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1897216

 

[GutEcologist]

The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice​

Yong Fan et al 2023 PMID: 37069399 DOI: 10.1038/s41564-023-01355-5 https://pubmed.ncbi.nlm.nih.gov/37069399/