FMT Faecal microbial transfer and complex carbohydrates mediate protection against COPD (Feb 2024, mice)

Fecal Microbiota Transplants

Michael Harrop

Active member
Jul 6, 2023


Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic lung diseases via the gut-lung axis, but its role is unclear.

Design Using an in vivo mouse model of cigarette smoke (CS)-induced COPD and faecal microbial transfer (FMT), we characterised the faecal microbiota using metagenomics, proteomics and metabolomics. Findings were correlated with airway and systemic inflammation, lung and gut histopathology and lung function. Complex carbohydrates were assessed in mice using a high resistant starch diet, and in 16 patients with COPD using a randomised, double-blind, placebo-controlled pilot study of inulin supplementation.

Results FMT alleviated hallmark features of COPD (inflammation, alveolar destruction, impaired lung function), gastrointestinal pathology and systemic immune changes. Protective effects were additive to smoking cessation, and transfer of CS-associated microbiota after antibiotic-induced microbiome depletion was sufficient to increase lung inflammation while suppressing colonic immunity in the absence of CS exposure. Disease features correlated with the relative abundance of Muribaculaceae, Desulfovibrionaceae and Lachnospiraceae family members. Proteomics and metabolomics identified downregulation of glucose and starch metabolism in CS-associated microbiota, and supplementation of mice or human patients with complex carbohydrates improved disease outcomes.

Conclusion The gut microbiome contributes to COPD pathogenesis and can be targeted therapeutically.
Format correct?
  1. Yes
As is typical for FMT, it seems that it can do both.

“The gut hosts the largest and most diverse microbiome in the body that, depending upon its composition, can either trigger or inhibit inflammation, including in the lung,” said senior study author Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation.

Professor Hansbro added that the study had also demonstrated the potential effectiveness of faecal microbiota transfer (FMT) in the treatment of COPD.