Differences in receiving fecal transplants (FMT) from male vs. female donors? And different age groups and enterotypes

coldcast

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I was curious about potential differences from receiving a transplant from a male vs. female donor.

I'm a middle aged male and I was confused between whether I should seek out a female or male recipient.

I'm leaning on finding a female donor considering that the mother provides the first major inoculation of bacteria for the growing baby (assuming natural birth and breastfeeding). I know that the mother is only the first, but not the only entity involved in inoculating us as we grow up.

I know that the donor should also be screened for a lot of different things, I'm assuming that this donor would pass on all other criteria, but its more the issue of their sex, age and enterotype that interests me.

Would it be better to receive from a younger person (like 14-15) or an older person? (35+)?

Also, another question, would it be better to aim for a particular enterotype? or is there an enterotype to receive from that is "totally okay"?

I was leaning on finding a donor with the Prevotella or Ruminococcus enterotype, but I know that the Bacteroides enterotype isn't totally bad either.

Would love to hear more from people who know about this. I'm a type 1 diabetic (born through C-section as well, not breastfead continuously) and have tried poring through the research as to what might be beneficial for me microbe wise. I even got a test of my gut microbiome and it's crazy that 26% of the bacteria in my gut are labeled as OTHER! I haven't seen that in other microbiome tests out there, and even saw some correlations with what is in my stomach with what has been presented in the research on people with Type 1 diabetes.

Anyways, would love an opinion or any thoughts on this. Thank you.
 
The evidence overwhelmingly supports universal donors (no need for matching). https://humanmicrobiome.info/fmt/

There's a section in the wiki that covers Donor-recipient matching: https://humanmicrobiome.info/fmt/#donor-recipient-matching, including evidence supporting and opposing the need for sex-matching.

If you scroll up a bit there's a section for Age as well. Plus: https://humanmicrobiome.info/aging/ which indicates that younger is generally better.

If you look at the humanmicrobes.org results (https://www.humanmicrobes.org/orders) there is no apparent connection between recipient-donor sex.

I've seen some people reporting they had a bad FMT outcome which they blamed on an opposite-sex donor, but these cases are almost certainly donor-quality related rather than donor-sex related. There are a lot of people with a poor understanding of human health and FMT donor quality and selection, and this leads them to use donors that they think are ideal but are actually quite bad.

Also, another question, would it be better to aim for a particular enterotype? or is there an enterotype to receive from that is "totally okay"?

I was leaning on finding a donor with the Prevotella or Ruminococcus enterotype, but I know that the Bacteroides enterotype isn't totally bad either.

This is not supported. See:

I even got a test of my gut microbiome and it's crazy that 26% of the bacteria in my gut are labeled as OTHER!
Indeed. https://humanmicrobiome.info/testing/
 
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