FMT Colonic distribution of FMT by different enema procedures compared to colonoscopy – proof of concept study using contrast fluid (Oct 2023, n=8)

Fecal Microbiota Transplants

Michael Harrop

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02979-x

Very interesting study out of Norway! As some people know, enema + positioning is something I've recommended for many years: https://humanmicrobiome.info/fmt/#lower-route. It has benefits over colonoscopy due to being safer and more convenient.

I've always been able to get the solution to my cecum, even at times when I couldn't do the enema right after a bowel movement. Usually I can feel the liquid moving through my colon and making it to the cecum.

Things you can do to ensure it makes it are to massage your abdomen to help it get there, and add enough liquid so that it flows easily.

Interestingly, 38% of their subjects had the liquid make it to their cecum even without doing any special positioning.

Also noteworthy is that they had their patients do a bowel cleanse beforehand. I don't do or recommend this anymore (seems unnecessary). I just do it shortly after a regular bowel movement.

They used:
fifty grams of freshly delivered feces from a healthy donor is mixed with 25 mL 85% glycerol and isotonic saline to a total volume of 200 mL.
Which is quite similar to the amount and consistency that I use.

So it seems that even if you follow my directions precisely, about 50% of people may have trouble getting the liquid to their cecum. I wonder why. They speculate on possible reasons in their discussion section https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02979-x#Sec8, but note that they need a larger sample size.
 
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