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  1. Michael Harrop

    Has anyone else tried Keto Diet or similar to modify their gut biome?

    Keto was horrible for me. It's an elimination diet for people who can't digest various carbs properly. Unfortunately, most of those people don't understand their condition, and the gut microbiome, and thus proselytize the diet to everyone...
  2. Michael Harrop

    FMT Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability (Jul 2025, n=12, enema over 6 mo, Biomebank) No significant motor symptom changes. No sustained improvement in non-motor symptoms.

    https://www.nature.com/articles/s41531-025-01061-5 Australian group that used the TGA-approved, GMP stool bank. More evidence that GMP stool banks are not valid approaches to FMT.
  3. Michael Harrop

    Article Inside the Collapse of the F.D.A. How the new health secretary, Robert F. Kennedy Jr., is dismantling the agency (Jul 2025)

    https://www.nytimes.com/2025/07/08/magazine/fda-collapse-rfk-kennedy.html Includes some comments by the former FDA commissioner, Robert Califf. And ends with: NYT's article title is blaming RFK for cuts he wasn't responsible for. As far as I know, it was DOGE and the Office of Management...
  4. Michael Harrop

    Testing Blood Test Spots Early Cancer with 95% accuracy Using Gut Bacteria RNA (Jul 2025) Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

    https://scienceblog.com/blood-test-spots-early-cancer-using-gut-bacteria-rna/ https://www.nature.com/articles/s41587-025-02731-8
  5. Michael Harrop

    Review Weedkiller ingredient banned in the UK, EU, China, but widely used in US can damage organs and gut bacteria (May 2025, review) Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

    https://www.theguardian.com/environment/2025/jul/06/weedkiller-diquat-organ-damage-study https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1562182/full
  6. Michael Harrop

    Article Finch wins US jury trial against Ferring over fecal-transplant patents (Aug 2024, Rebyota)

    As far as I know, the FDA does not allow pooling donors' stool. I haven't been able to find what is in Rebyota. If anyone has a link, I'll take a look.
  7. Michael Harrop

    FMT Gut Microbiome rewiring via fecal transplants: Uncovering therapeutic avenues in Alzheimer’s disease models (Jul 2025, mice) FMT from AD to healthy mice induced profound memory impairment and cognitive deficits. FMT from healthy mice yielded remarkable behavioral improvements

    https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00953-9
  8. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Meet Jim O’Neill, the longevity enthusiast who is now RFK Jr.’s right-hand man (Jun 2025) https://www.technologyreview.com/2025/06/30/1119449/hhs-robert-f-kennedy-jr-jim-oneill-longevity-maha/ Seems like more good news, yet still no action on FMT. https://humanmicrobiome.info/aging/ Jim...
  9. Michael Harrop

    FMT Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study (Jul 2025, n=22) 68.1% reduction in urinary infectious episodes, eradication of fecal colonization of urinary pathogens that were resistant to multiple antibiotics

    https://link.springer.com/article/10.1007/s10096-025-05202-9 Almost no donor info:
  10. Michael Harrop

    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    https://www.nytimes.com/2025/07/02/health/ai-chatgpt-research-papers.html https://www.science.org/doi/10.1126/sciadv.adt3813 I think this is a huge problem given how flawed the peer review system is. I highly doubt that peer review is able to adequately fact-check the papers and all the...
  11. Michael Harrop

    FMT Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice (Jun 2025) "human-derived microbiota was less effective in clearing C. difficile compared to a mouse-derived microbiota"

    Discussion with the researchers: Why Fecal Transplants Sometimes Fail: Function, Not Just Colonization, May Hold the Key https://www.contagionlive.com/view/why-fecal-transplants-sometimes-fail-function-not-just-colonization-may-hold-the-key
  12. Michael Harrop

    Article Trump’s First EPA Promised to Crack Down on Forever Chemicals. His Second EPA Is Pulling Back (Jun 2025)

    https://www.propublica.org/article/trump-epa-pfas-drinking-water
  13. Michael Harrop

    Study Certain species of microbe found in the human gut can absorb PFAS (Jul 2025) Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances

    https://phys.org/news/2025-06-species-microbe-human-gut-absorb.html https://www.cam.ac.uk/research/news/gut-microbes-could-protect-us-from-toxic-forever-chemicals https://www.nature.com/articles/s41564-025-02032-5
  14. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    All used up over the past 10+ years. Well I'm still basically the only person doing anything. Vaccines are mostly unrelated to the microbiome and chronic disease. If anything, everything they're doing wth vaccines is a red herring, distracting from the real issue, which has been ignored so...
  15. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    That's not what's happening. Pharma companies don't have to do anything but sit by and watch the public research system continually, incompetently fail to make a simple treatment/cure available. No one has to hide or bury anything; they can simply not try, because the FDA is preventing anyone...
  16. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    https://boingboing.net/2025/06/27/rfk-jrs-maga-project-funnels-millions-from-public-health-to-private-wellness-industry.html https://www.accountabilityjournalism.org/insights/mahas-goal-is-not-health Some parts seem concerning. Other parts are written to raise concern, but aren't necessarily...
  17. Michael Harrop

    Causation Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation (Jun 2025, mice) Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry

    Study: https://www.nature.com/articles/s41586-025-09120-w Commentary: https://www.nature.com/articles/s41577-025-01201-1
  18. Michael Harrop

    Early development U.S. Babies Are Missing a Key Gut Microbe, Fueling Allergy Risk (Jun 2025, n=412) Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis

    https://gizmodo.com/study-says-u-s-babies-are-missing-a-key-gut-microbe-fueling-allergy-risk-2000619622 https://www.nature.com/articles/s42003-025-08274-7
  19. Michael Harrop

    Other 'Microbial Noah's Ark' ramps up to save Earth's invisible life forms (Jun 2025) The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

    https://phys.org/news/2025-06-microbial-noah-ark-ramps-earth.html https://www.nature.com/articles/s41467-025-61008-5 It's a follow-up to this: Preserving microbial diversity (Oct 2018)
  20. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Two new hearings: Jun 25, 2025. Health, Education, Labor, and Pensions (HELP). Hearings to examine the nomination of Dr. Susan Monarez to head the CDC...
  21. Michael Harrop

    Article US FDA Makary’s Pharma CEO Tour Goes Against Transparency Rhetoric (May 2025) CEO Forums: An FDA Listening Tour to Engage Pharma CEOs

    https://insights.citeline.com/pink-sheet/agency-leadership/us-fda/us-fda-makarys-pharma-ceo-tour-goes-against-transparency-rhetoric-3E5RP5IATVD73DRPQHZPSTHKRA/ https://www.fda.gov/industry/ceo-forums-fda-listening-tour-engage-pharma-ceos Related: FDA Commissioner Marty Makary Announces Major...
  22. Michael Harrop

    Article FDA Commissioner Marty Makary Announces Major New Policy to Limit Conflicts of Interest (Apr 2025) "we are removing industry members – pharma members – from FDA advisory committees"

    https://www.megynkelly.com/2025/04/17/marty-makary-announces-policy-to-limit-big-pharma-conflicts-of-interest-at-fda/
  23. Michael Harrop

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Rule 9: https://forum.humanmicrobiome.info/threads/rules-info-submission-guidelines-features.20/ SIBO is not a real condition. https://humanmicrobiome.info/sibo/
  24. Michael Harrop

    Procedure SMT from China (selective microbiota transplantation)

    Could you share more info on SMT? This is not surprising at all, and isn't a reason to opt for SMT instead of FMT. The issue you experienced is due to their donors: https://humanmicrobiome.info/where-to-get-fmt/
  25. Michael Harrop

    Donors Has anyone tried children as stool donors for FMT?

    Yes, many people have used children for FMT with success. There is a bit of info in this thread on that too: https://forum.humanmicrobiome.info/threads/does-stool-donor-sex-and-age-matter-are-there-differences-in-receiving.416/
  26. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    I don't think they "suggest" it, but they are working on including euthanasia for mental illness in their current law. I generally support that, but it's off-topic for this thread. There are some Youtube videos where patients give their perspective.
  27. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    In the "conflicts of interest" section it says:
  28. Michael Harrop

    It's in the same place in the probiotic guide. I just clarified the wording and removed a dead link.

    It's in the same place in the probiotic guide. I just clarified the wording and removed a dead link.
  29. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx The usual poor donor criteria. Sometimes low-quality donors turn out worse than other times.
  30. Michael Harrop

    Study Glass bottles found to contain more microplastics than plastic bottles; mostly from the plastic paint on the caps (May 2025) Microplastic contaminations in a set of beverages sold in France

    https://phys.org/news/2025-06-glass-bottles-microplastics-plastic.html https://www.sciencedirect.com/science/article/pii/S0889157525005344
  31. Michael Harrop

    Causation Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis (Mar 2025)

    https://www.psypost.org/gut-bacteria-may-play-a-causal-role-in-obsessive-compulsive-disorder-study-suggests/ https://www.sciencedirect.com/science/article/abs/pii/S0165032725003167
  32. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    Do you have a really bad memory? We've discussed this before, and I've repeatedly written about it on the blog and forum. Your query should also be obviously erroneous to most people, so perhaps your memory is not the issue. 1. None of my donors have ever failed a test. Testing them once is not...
  33. Michael Harrop

    Aging Causal Analysis Between Gut Microbes, Aging Indicator, and Age-Related Disease, Involving the Discovery and Validation of Biomarkers (Apr 2025) "Gut microbiota a potential risk factor for 14 age-related diseases. Exhibit biomarker properties for disease prediction"

    https://www.fightaging.org/archives/2025/06/evidence-of-causation-in-human-data-on-the-gut-microbiome-and-age-related-conditions/ https://onlinelibrary.wiley.com/doi/10.1111/acel.70057
  34. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2508950 UMN GMP stool bank provides insights from their and other companies' experiences. UMN appears to have some of the worst donors that exist anywhere. Interestingly, they mention relevant info about the donor recruitment, payment...
  35. Michael Harrop

    Article The Secret Gamble at the FDA That Exposed Americans to Risky Drugs (Jun 2025) Factories, mostly in India, where inspectors found contaminated drugs, filthy labs, and falsified records, were given a pass to continue sending drugs to the US.

    https://www.propublica.org/article/fda-drug-loophole-sun-pharma
  36. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I don't think that's correct. You shouldn't need huge groups of people with FMT success stories. There's a huge body of scientific evidence supporting the gut microbiome and FMT, which should be enough to get the support of the majority of people in the chronic disease communities. It's been...
  37. Michael Harrop

    Other H. Pylori bacteria that causes stomach ulcers may protect the brain from Alzheimer’s and Parkinson’s (Jun 2025) Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

    https://theconversation.com/alzheimers-bacteria-that-cause-stomach-ulcers-may-protect-the-brain-our-new-research-indicates-259018 https://www.science.org/doi/10.1126/sciadv.ads7525
  38. Michael Harrop

    FMT Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection: A Randomized Controlled Trial (Jun 2025, n=104) "Clinical cure with no recurrence seen in 67% for FMT vs 61% for vancomycin. Up to 78% for FMT with additional treatment"

    https://www.acpjournals.org/doi/10.7326/ANNALS-24-03285 This is a unique study because usually FMT is only given after antibiotics fail.
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