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  1. O

    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    Look up neuro-symbolic AI, state space models, graph neural networks and spiking neural networks. For reasons unknown to me lots of people treat LLMs as the pinnacle of AI development while in reality they're just the starting point, similar to how Apple II was the starting point for personal...
  2. O

    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    Note that this won't continue forever - LLMs hallucinate because of the way they work, being statistical pattern matchers and not true thinkers - but in a couple of years they will be replaced by newer, better AI paradigms that will be many times more powerful and hallucination-free. The future...
  3. O

    Article FDA names former pharmaceutical company executive, Dr. George Tidmarsh, to oversee US drug program, CDER (2025)

    Ok I really misunderstood you. Treat my previous post as never written.
  4. O

    Article FDA names former pharmaceutical company executive, Dr. George Tidmarsh, to oversee US drug program, CDER (2025)

    The whole purpose of MAGA is to take the last brakes off corporations so that they can run loose and get even richer. I can't believe anyone in the US can be naive enough to believe otherwise. Reps vs Dems fight isn't a fight of the common people versus the elites, at best it's just infighting...
  5. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    A decent approach might be to try to convince a doctor - preferably a gastroenterologist - of the merits of FMT. Doctors have more authority than a common person and they have connections with other doctors whom they should be able to convince as well.
  6. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Everything is fine. They aren't rejecting any FMT comments. If I am not mistaken, scienceforums.net has a rule that posts of new users need to be approved by moderation. I registered over a year ago, i can't remember everything.
  7. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Perhaps you are right. Nonetheless, I am glad that I was able to help even in this modest way.
  8. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop After some thought I think that people on scienceforums.net do have a point. In science - including medicine - everything is considered unproven until proven otherwise. You have laser focused on FMT as an almost holy grail-like thing and presented it like it was a proven...
  9. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop - I've asked a mod (swansont, the one with physics PhD) for permission to open a thread. Give me the link to your summary so I can send it to him if possible. EDIT: Permission granted. Now I just need to write a good OP.
  10. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    www.scienceforums.net :) I shall make a thread on your behalf soon. What should i write, though? Are you looking for donors? Financial assistance? Both? Something else perhaps? What I write and how I phrase it will be very important.
  11. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Many folks have the same issues as you - a one man army can only achieve so much, especially if it's mode of an individual with no financial, social or political capital. I respect your work greatly. Since I am a member of a major science-related discussion forum, I can ask...
  12. O

    dzsqualala cures PSSD with DIY FMT from brother (Post-SSRI Sexual Disorder, fecal microbiota transplant, 2023)

    @Michael Harrop - Thank you for your link. Now I understand your line of reasoning. The problem IMHO boils down to simple evolutionary heritage - humans never evolved to live in the current world, nor to be completely rational, we evolved to live as hunter gatherers on African savanna, in...
  13. O

    dzsqualala cures PSSD with DIY FMT from brother (Post-SSRI Sexual Disorder, fecal microbiota transplant, 2023)

    @Michael Harrop Regarding subreddits - folks who post there tend to seek validation. Chronic diseases, with the constant pain, fatigue, brain fog, unending doctor appointments etc. is something that their families, friends and even doctors often don't fully understand. And these sorts of online...
  14. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Neil deGrasse Tyson is the public face of science at least in the US. He cannot afford to promote stuff that is not 100% proven because if even some of it is proven wrong, he will be accused of spreading pseudoscience and the entire scientific endeavour will suffer. Additionally, his lifelong...
  15. O

    Fermented foods and gut microbiome

    What do studies show about that precise matter? Are fermented foods beneficial? If yes, to what degree? I myself love eating kimchi and I'd like to know if it might have any positive effect on me besides immediate gustatory satisfaction.
  16. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Neil deGrasse Tyson (the spiritual successor of Carl Sagan) covered the gut-brain axis in a StarTalk episode a month ago, the video had 320,000 views as of now. Perhaps you could at least try to contact him? https://www.youtube.com/watch?v=fIeVrVm1W1A
  17. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Nothing can translate into a widely used therapy until phase 3 trials are completed - and they cost a lot.
  18. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    A few months ago I read an article from 2019 about Alzheimer's research - progress got stalled by 10-15 years simply because senior researchers refused to fund or publish ANYTHING that wasn't about amyloid. And it shows quite clearly that even among scientists, a group expected to be highly open...
  19. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    To be specific, I would gladly accept more FMT research regardless of what political background it comes from.
  20. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Will there even be money for clinical trials? I don't follow US domestic politics but I do know that there have been massive budget cuts to scientific research in the US - including $2.7 bln cuts to NIH funded research. They have the potential to make the whole US science moribund.
  21. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Personally I wouldn't expect much from RFK Jr given that he is a nearly stereotypical crank. Even leaving aside his usual anti vaxx stuff, he holds a lot of other idiotic beliefs HIV denialism denial of the link between UV exposure and skin cancer, detoxification BS (belief that diseases...
  22. O

    Causation The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study (Apr 2025)

    That's... intriguing. While I know a lot about the potential of gut microbes to treat a vast range of diseases - I am much less informed about it's potential to treat diseases like mine - and even less so about the role of the immune system in it.
  23. O

    Causation The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study (Apr 2025)

    I have poor eyesight due to Retinopathy of Prematurity - retinal scarring limits my visual resolution since my brain has to construct image from a smaller amount of information. I just doubt gut microbiome manipulation could help me as retinal cells don't regenerate :(
  24. O

    Other An imbalance of gut metabolites in children with autism disrupts neurotransmitter production, influencing behavioral symptoms (Apr 2025, n=84) Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology

    Another autism study, nice! I would like to do some personality and cognitive optimization of myself and I am frustrated how slow the pace of development is. The standard of care for Neuroticism are the SSRIs which were introduced in 1987, the same year Amiga 500 was released. Can you imagine...
  25. O

    Causation The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis (Sep 2024)

    I wonder what microorganisms might influence visuospatial memory? I have poor visuospatial memory which makes it hard for me to memorize streets and Chinese characters. My background - a premie born 2 months too soon. I suffered 2 bouts of pneumonia in an ICU due to de facto medical negligence...
  26. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Have you tried contacting doctors who might help you popularize FMT? They might be more open minded than politicians and they have more authority than random people like us.
  27. O

    Causation The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis (Sep 2024)

    I will be a genius in the future? Yess. 😺
  28. O

    State of microbiome-based therapies 5-10 years from now?

    @Michael Harrop I would do FMT some 3-5 years from now but I have some doubts: While there are certain traits like emotional stability, working and visuospatial memory, which I'd like to improve, there are others that I very clearly don't want to change I don't want to lose my extreme...
  29. O

    State of microbiome-based therapies 5-10 years from now?

    What will be the state of affairs in the field in 5-10 years? Especially in cognitive and mental health? Will FMT still be a thing or perhaps newer, better therapies will be available? I am not overall unhealthy and I would rate my personality at 6.5/10 and my cognitive health at 7/10 at age...
  30. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Sorry to say this but you've probably already lost your battle :( Research (conducted in the US itself) says that what bottom 90% of Americans want has zero influence on actual US government policies. The top 10% is much more influential...
  31. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop I can partially agree with you. While it's true that Bernie should know about the FMT, the issue with his staffers is less clear. Each day they receive dozens - if not hundreds - of e-mails from various tinfoil hatters and cranks who think they've discovered some absolute...
  32. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Im asking again - how can Bernie Sanders even know about FMT/microbiome? There are basically three groups of people who know about it: 1. Medical researchers 2. Science enthusiasts 3. Patients. Since he doesn't belong to any of the above, how could he know? And if he doesn't...
  33. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop But is Bernie Sanders really a narcissist/psychopath or just ill informed? The FMT and all other microbiome stuff is still a new thing, known only to a handful of scientists/researchers... If you went back in time to say 1865 and asked 100 physicians about the germ theory, the...
  34. O

    FMT Effects and microbiota changes following oral lyophilized fecal microbiota transplantation in children with autism spectrum disorder (May 2024, n=38, 1x/4 week for 12 weeks)

    Does the results mean that core Autism symptoms reduced by 23%?
  35. O

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    By the way all of this shows just how little we know about the human microbiome... A long way ahead.
  36. O

    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Any specific ways to clear/destroy the mucus membrane? Would a colon cleanse before FMT do it?
  37. O

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    I wonder if there is an impact on lifespan? It'd be nice if everyone could live to 105-110 thanks to FMT. :)
  38. O

    Oral Carbon beads help reduce liver disease by modifying gut microbiome (Apr 2024) Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis

    https://www.medicalnewstoday.com/articles/carbon-beads-may-help-reduce-liver-disease-restore-gut-health https://gut.bmj.com/content/early/2024/04/24/gutjnl-2023-330699 This is interesting although it's not FMT.
  39. O

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    Isn't the poor response due to simply poor engraftment?
  40. O

    Enhancing FMT engraftment

    Do we know what is the average engraftment/success rate of FMT and what are the possible factors increasing it's efficiacy?
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