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  1. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    That's not what's happening. Pharma companies don't have to do anything but sit by and watch the public research system continually, incompetently fail to make a simple treatment/cure available. No one has to hide or bury anything; they can simply not try, because the FDA is preventing anyone...
  2. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    https://boingboing.net/2025/06/27/rfk-jrs-maga-project-funnels-millions-from-public-health-to-private-wellness-industry.html https://www.accountabilityjournalism.org/insights/mahas-goal-is-not-health Some parts seem concerning. Other parts are written to raise concern, but aren't necessarily...
  3. Michael Harrop

    Causation Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation (Jun 2025, mice) Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry

    Study: https://www.nature.com/articles/s41586-025-09120-w Commentary: https://www.nature.com/articles/s41577-025-01201-1
  4. Michael Harrop

    Early development U.S. Babies Are Missing a Key Gut Microbe, Fueling Allergy Risk (Jun 2025, n=412) Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis

    https://gizmodo.com/study-says-u-s-babies-are-missing-a-key-gut-microbe-fueling-allergy-risk-2000619622 https://www.nature.com/articles/s42003-025-08274-7
  5. Michael Harrop

    Other 'Microbial Noah's Ark' ramps up to save Earth's invisible life forms (Jun 2025) The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

    https://phys.org/news/2025-06-microbial-noah-ark-ramps-earth.html https://www.nature.com/articles/s41467-025-61008-5 It's a follow-up to this: Preserving microbial diversity (Oct 2018)
  6. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Two new hearings: Jun 25, 2025. Health, Education, Labor, and Pensions (HELP). Hearings to examine the nomination of Dr. Susan Monarez to head the CDC...
  7. Michael Harrop

    Article US FDA Makary’s Pharma CEO Tour Goes Against Transparency Rhetoric (May 2025) CEO Forums: An FDA Listening Tour to Engage Pharma CEOs

    https://insights.citeline.com/pink-sheet/agency-leadership/us-fda/us-fda-makarys-pharma-ceo-tour-goes-against-transparency-rhetoric-3E5RP5IATVD73DRPQHZPSTHKRA/ https://www.fda.gov/industry/ceo-forums-fda-listening-tour-engage-pharma-ceos Related: FDA Commissioner Marty Makary Announces Major...
  8. Michael Harrop

    Article FDA Commissioner Marty Makary Announces Major New Policy to Limit Conflicts of Interest (Apr 2025) "we are removing industry members – pharma members – from FDA advisory committees"

    https://www.megynkelly.com/2025/04/17/marty-makary-announces-policy-to-limit-big-pharma-conflicts-of-interest-at-fda/
  9. Michael Harrop

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Rule 9: https://forum.humanmicrobiome.info/threads/rules-info-submission-guidelines-features.20/ SIBO is not a real condition. https://humanmicrobiome.info/sibo/
  10. Michael Harrop

    Procedure SMT from China (selective microbiota transplantation)

    Could you share more info on SMT? This is not surprising at all, and isn't a reason to opt for SMT instead of FMT. The issue you experienced is due to their donors: https://humanmicrobiome.info/where-to-get-fmt/
  11. Michael Harrop

    Donors Has anyone tried children as stool donors for FMT?

    Yes, many people have used children for FMT with success. There is a bit of info in this thread on that too: https://forum.humanmicrobiome.info/threads/does-stool-donor-sex-and-age-matter-are-there-differences-in-receiving.416/
  12. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    I don't think they "suggest" it, but they are working on including euthanasia for mental illness in their current law. I generally support that, but it's off-topic for this thread. There are some Youtube videos where patients give their perspective.
  13. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    In the "conflicts of interest" section it says:
  14. Michael Harrop

    It's in the same place in the probiotic guide. I just clarified the wording and removed a dead link.

    It's in the same place in the probiotic guide. I just clarified the wording and removed a dead link.
  15. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx The usual poor donor criteria. Sometimes low-quality donors turn out worse than other times.
  16. Michael Harrop

    Study Glass bottles found to contain more microplastics than plastic bottles; mostly from the plastic paint on the caps (May 2025) Microplastic contaminations in a set of beverages sold in France

    https://phys.org/news/2025-06-glass-bottles-microplastics-plastic.html https://www.sciencedirect.com/science/article/pii/S0889157525005344
  17. Michael Harrop

    Causation Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis (Mar 2025)

    https://www.psypost.org/gut-bacteria-may-play-a-causal-role-in-obsessive-compulsive-disorder-study-suggests/ https://www.sciencedirect.com/science/article/abs/pii/S0165032725003167
  18. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    Do you have a really bad memory? We've discussed this before, and I've repeatedly written about it on the blog and forum. Your query should also be obviously erroneous to most people, so perhaps your memory is not the issue. 1. None of my donors have ever failed a test. Testing them once is not...
  19. Michael Harrop

    Aging Causal Analysis Between Gut Microbes, Aging Indicator, and Age-Related Disease, Involving the Discovery and Validation of Biomarkers (Apr 2025) "Gut microbiota a potential risk factor for 14 age-related diseases. Exhibit biomarker properties for disease prediction"

    https://www.fightaging.org/archives/2025/06/evidence-of-causation-in-human-data-on-the-gut-microbiome-and-age-related-conditions/ https://onlinelibrary.wiley.com/doi/10.1111/acel.70057
  20. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2508950 UMN GMP stool bank provides insights from their and other companies' experiences. UMN appears to have some of the worst donors that exist anywhere. Interestingly, they mention relevant info about the donor recruitment, payment...
  21. Michael Harrop

    Article The Secret Gamble at the FDA That Exposed Americans to Risky Drugs (Jun 2025) Factories, mostly in India, where inspectors found contaminated drugs, filthy labs, and falsified records, were given a pass to continue sending drugs to the US.

    https://www.propublica.org/article/fda-drug-loophole-sun-pharma
  22. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I don't think that's correct. You shouldn't need huge groups of people with FMT success stories. There's a huge body of scientific evidence supporting the gut microbiome and FMT, which should be enough to get the support of the majority of people in the chronic disease communities. It's been...
  23. Michael Harrop

    Other H. Pylori bacteria that causes stomach ulcers may protect the brain from Alzheimer’s and Parkinson’s (Jun 2025) Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

    https://theconversation.com/alzheimers-bacteria-that-cause-stomach-ulcers-may-protect-the-brain-our-new-research-indicates-259018 https://www.science.org/doi/10.1126/sciadv.ads7525
  24. Michael Harrop

    FMT Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection: A Randomized Controlled Trial (Jun 2025, n=104) "Clinical cure with no recurrence seen in 67% for FMT vs 61% for vancomycin. Up to 78% for FMT with additional treatment"

    https://www.acpjournals.org/doi/10.7326/ANNALS-24-03285 This is a unique study because usually FMT is only given after antibiotics fail.
  25. Michael Harrop

    Discussion Feel free to provide feedback for a new logo

    I saw an article that said ChatGPT is still the best at creating images. So I gave it various prompts, which resulted in these mockups, but I'm not a huge fan of any of them: I prompted it to "Make the head a petri dish that looks like a speech bubble", but it had trouble doing that. I like...
  26. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    There is no one person whom people should just randomly contact. You need to have a single coherent message and request. That's why petitions are used. You would need one letter/petition, similar to this. But 10 anonymous votes on that post is nothing. An actual petition that people sign with...
  27. Michael Harrop

    Article Dwayne 'The Rock' Johnson reveals surprising health battle and how he fought back (Jun 2025) "digestive issues linked to prior courses of antibiotics"

    https://archive.ph/MoK5H https://www.thenews.com.pk/latest/1321180-dwayne-johnson-reveals-shocking-battle-with-years-of-health-problems Interesting article with some important info and some pseudoscience. The first part is alarmingly common, and a major root cause of the chronic disease...
  28. Michael Harrop

    dzsqualala cures PSSD with DIY FMT from brother (Post-SSRI Sexual Disorder, fecal microbiota transplant, 2023)

    That is covered in the wiki: https://humanmicrobiome.info/fmt/ The biggest problem most people have is finding a safe and effective donor. I've been trying to solve that problem, and here is the current status...
  29. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Thanks for the info. A few thoughts: I have contacted dozens of similar people. They do not respond. My health is not good enough to go on podcasts. A person with his reputation is unlikely to do something risky like bring on someone like me (a patient with no formal education, who has been...
  30. Michael Harrop

    FMT The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study (Jun 2025, n=172). Partial remission 55%, complete remission 32% for resistance training group, and 67% partial, 45% complete for FMT+resistance group

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06557-5
  31. Michael Harrop

    FMT Fulminant Clostridioides difficile Infection Following Fecal Microbiota Spores Compared to Fecal Microbiota Transplant (May 2025, n=130) Patients receiving VOUST's fecal microbiota spores live-brpk were more likely to develop severe disease, called fulminant C. diff infection

    https://www.newswise.com/articles/new-treatment-for-c-diff-infection-may-be-less-effective-than-traditional-therapy-study-finds/ https://www.cghjournal.org/article/S1542-3565(25)00420-3/abstract Closed access.
  32. Michael Harrop

    FMT Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results (Jun 2025, n=4) "FMT through colonoscopy showed improvement in pain, bloating, and stool consistency that was maintained during the 6-month follow-up"

    https://www.sciencedirect.com/science/article/pii/S2255534X25000647
  33. Michael Harrop

    Probiotics Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial (Jun 2025, n=190) "incidence of POCD in the probiotic group was significantly lower than in the control group"

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06584-2
  34. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    There are severe limits to what I can do on my own. I need help, and I should be getting help.
  35. Michael Harrop

    Study Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs (Jun 2025, mice)

    https://www.nature.com/articles/s41467-025-59884-y
  36. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Another NIH/Dr. Bhattacharya hearing: https://www.appropriations.senate.gov/hearings/a-review-of-the-presidents-fiscal-year-2026-budget-request-for-the-national-institutes-of-health Another hearing where an existing treatment for most chronic diseases is ignored. Dr. Bhattacharya says the right...
  37. Michael Harrop

    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    Haha. I was also going to use stronger language at first :) I definitely agree they are overstating their results, and the authors seem uninformed about the body of evidence contradicting their statements. Agree. Also, my understanding is that there are simply different percentages of...
  38. Michael Harrop

    Advocacy Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT)

    Senator Bill Cassidy and other Republicans have been taking steps to reform NIH since at least 2023: https://www.aip.org/fyi/republicans-push-nih-reform I read his white papers and strongly support his efforts, but it sounds like it's largely up to NIH and RFK/HHS to actually implement the...
  39. Michael Harrop

    Article White House releases RFK Jr.-led report on chronic disease (May 2025) The MAHA Report, Make Our Children Healthy Again Assessment

    Given the suggestion of AI involvement in the writing of the document, I decided to ask ChatGPT: What are the main causes of the chronic disease crisis? It said: I asked: Why didn't you mention the gut microbiome and antibiotics? It said:
  40. Michael Harrop

    Fermented foods and gut microbiome

    https://humanmicrobiome.info/probiotic-guide - they can be, but they're largely overhyped, limited, and can have detriments. It's quite difficult (and not fully studied) to determine and weigh all the pros & cons. And as with most things, it varies from person to person, so you'll have to...
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