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  1. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    It's also a 5-HT2C (one of the serotonin receptors, that plays a role in limiting the effectiveness of SSRIs) antagonist. There are multiple fates of tryptophan--being made into protein, acting as a NAD precursor, etc. 5-HTP can ONLY be used to make serotonin and melatonin. Provided that's what...
  2. S

    Procedure FMT implant advice/conundrum (clinic vs DIY)

    It seems your experience fits exactly what I was saying--your most effective experience so far has been with deep retention enema. Most donors you have done only capsules with have been of limited effectiveness. To my knowledge you have never had a FMT via gastroscopy, so you cannot comment on...
  3. S

    FMT Openbiome Sep-Dec 2024 updates. Distribution will cease on Dec 31, or when their IND Phase 2 protocol is cleared to proceed.

    Interesting, I thought they had stopped shipping back in 2021 as you'd said. Not that it matters for most of us who don't have C. diff. I will definitely consider writing to the FDA, telling them about my excellent experience with FMT from OpenBiome (which addressed much more than just C. diff).
  4. S

    Human Microbes HumanMicrobes.org, Donor NY-KS-1998. Treating CFS, IBS, mild Alzheimers. Large improvements to skin, stool quality, IBS. Mild to moderate improvements to fatigue, sleep, sex drive. Time to focus on Step #3 (2024)

    Have you tried any of these other methods and had them actually work? It seems not, otherwise you would have gotten one of the good donors to "stick". If they don't work, then why use them??
  5. S

    Procedure FMT implant advice/conundrum (clinic vs DIY)

    I'm guessing you're not in the United States, judging based on the clinics and suppliers that are available to you. Human Microbes was the only US supplier for DIY FMT, and they are no longer shipping, which means now there are zero based here--and no clinics offer endoscopic FMT treatment for...
  6. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1. I have a degree in biochemistry and work in a neurobiology lab, and I've also looked into a lot of things as possible treatments for my own condition (which is some sort of neuro-immune condition that has never been formally diagnosed, though I see similarities to experiences of families with...
  7. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Pendulum started selling an A. muciniphila probiotic just a year or two ago. Candidatus Saccharimonas has not even been cultured, let alone commercialized, it's only known to exist by its DNA sequence that has been caught floating around in samples. Nobody even knows what the cells look like...
  8. S

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    What is "a project like this"? In other words, who gets to decide who the recipients are, what the inclusion/exclusion criteria are for people being treated, and analyzes the results (including determining what counts as a "success" or doesn't? What route of administration will be tested? As...
  9. S

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I have to wonder if the majority of people, legislators included, consider the main roadblock here to be scientific/medical, rather than legislative. In other words, they think that we first need to figure out the optimal way to technically carry out a FMT (including, but certainly NOT limited...
  10. S

    Smell and microbiome

    Do you mean the smell of your stool? or the smell of your skin/sweat? Nearly all "sulfur smell" comes from the microbiome--the sulfur-containing amino acids that make up part of our own cells don't smell strongly like sulfur, that requires that bacteria break them down into smaller, volatile...
  11. S

    I suspect that the microbiota most direly missing from my own intestinal tract are mostly...

    I suspect that the microbiota most direly missing from my own intestinal tract are mostly facultative anaerobic small intestinal microbes (things like Actinomyces, Gemella, non-Copri strains of Prevotella, possibly Neisseria, etc.), NOT the kind of colonic anaerobes that are entirely focused on...
  12. S

    Human Microbes HumanMicrobes.org, Donor NY-KS-1998. Treating CFS, IBS, mild Alzheimers. Large improvements to skin, stool quality, IBS. Mild to moderate improvements to fatigue, sleep, sex drive. Time to focus on Step #3 (2024)

    What do you think is best? Something like vancomycin? Before I received the FMT that ended up being most helpful for me, I indeed took vancomycin for more than a month. In my case I had to, because I had active C. diff and couldn't get in for a FMT before about 1.5 months after my positive...
  13. S

    Human Microbes Trial of glycerol-preserved UT-AW-1998 (Human Microbes) for gut pain, food intolerances, and cognitive/neuropsychiatric symptoms

    This is a follow-up to this experience, which I previously promised togive once more time had passed since the FMT. I'm posting as a separate thread because they may just as well have been different donors/sources, given the difference in effects. Both were only partial successes however. The...
  14. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Phages are part of the (normal) microbiome, so they're not by themselves the cause of dysbiosis or any disease. The cause of dysbiosis is essentially always either 1) excessive antibiotics, or 2) an infection of some kind (many people apparently get IBS after a bad bout of food poisoning). Some...
  15. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I tried apple cider vinegar once, with the idea that Acetobacter species are alpha-proteobacteria and therefore belong to a different part of the bacterial tree of life than nearly all other probiotics. And they are even part of the gut microbiomes of some species, particularly insects. I made...
  16. S

    Human Microbes Partial success with UT-AW-1998 for gut pain, food intolerances, and cognitive/mood symptoms (PANS-like)

    The first set of capsules (without additives) never increased stool firmness. There was always if anything the tendency toward diarrhea, even though the threshold to provoke it became greater the longer after starting treatment. The "constipating" or "firming" effect of the capsules WITH...
  17. S

    SIBO (just a symptom?), PPI's, Integrative Doctors, Functional Medicine

    This is exactly the story--both good and bad--with functional MDs/naturopaths. As you put it, they are some of the few medical professionals who accept that symptoms that are in completely different systems of the body can be connected, part of one "syndrome", and that treatments that truly heal...
  18. S

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Even my gastroenterologist who performed my most successful FMT (back when I had C. diff) said this much. We get certain bacteria from our parents and other people we are around as babies, either directly through the birth process and/or close contact, or indirectly through the shared home...
  19. S

    Human Microbes Partial success with UT-AW-1998 for gut pain, food intolerances, and cognitive/mood symptoms (PANS-like)

    Just a quick follow up... I have since ordered capsules from the same donor, but with glycerol added. Even after the first capsule, I was able to tell that this made a HUGE difference, and that difference has continued/held up so far. It feels significantly more like the 2015 FMT from OpenBiome...
  20. S

    Human Microbes Partial success with UT-AW-1998 for gut pain, food intolerances, and cognitive/mood symptoms (PANS-like)

    Why would this support my position that the chance of diarrhea (or any other negative effects) may be higher if the stool is used whole rather than filtered? As far as I know, no HMorg donor has EVER filtered their stool before sending to recipients, thus any change lately must be from something...
  21. S

    Human Microbes Partial success with UT-AW-1998 for gut pain, food intolerances, and cognitive/mood symptoms (PANS-like)

    That's in all honesty why I asked whether you have ever considered having donors filter/wash their stool before freezing. Not having tested a single donor filtered vs. unfiltered, and not knowing anyone else who has, I can't claim with evidence that this is the reason for people having these...
  22. S

    Human Microbes Partial success with UT-AW-1998 for gut pain, food intolerances, and cognitive/mood symptoms (PANS-like)

    First I will give a brief overview of where I was health-wise both prior to this FMT, and very briefly where I was prior to my OpenBiome FMT in 2015, with which this experience will be compared (since it's my only other FMT, hence my only reference point as to how successful this one was). You...
  23. S

    FMT Washed microbiota transplantation improves sleep quality in patients with sleep disorder by the gut-brain axis (Jun 2024, n=63)

    This is absolutely NOT MY personal experience. The FMT that had the most beneficial effects caused no temporary flaring of anything. In fact, this is my personal experience of medical treatments of ALL kinds--to the point where I've concluded that "die off reactions" are mostly a myth. The...
  24. S

    FMT Washed microbiota transplantation improves sleep quality in patients with sleep disorder by the gut-brain axis (Jun 2024, n=63)

    "1. There's no evidence that it's beneficial or necessary, so I wouldn't be interested." In the companion paper where they define what a "washed FMT" is, they claim a significant reduction (almost a halving) in rate of adverse effects. That's the basis on which they chose to even do the washing...
  25. S

    Other Why some feces float and others sink - some bacteria produce more gas than others (Oct 2022, mice) Genesis of fecal floatation is causally linked to gut microbial colonization in mice

    That only applies to the methane type that is common in IBS-C (though not exclusive to that).
  26. S

    FMT Washed microbiota transplantation improves sleep quality in patients with sleep disorder by the gut-brain axis (Jun 2024, n=63)

    What would it take to implement something like this at HMorg? They used a sophisticated filtration device for the medical laboratory environment that is likely far too expensive for the average donor to acquire, but something similar to the filtration bags used by OpenBiome...
  27. S

    Enhancing Antifreeze in stool/FMT capsules, glycerol vs maltodextrin, -80 (medical freezer) vs -20 (home freezer)

    I have looked at the papers that discuss using maltodextrin as a cryopreservative for FMT and/or other bacteria, including this one (https://www.nature.com/articles/s41598-019-45173-4), and ALL of them combine it with trehalose in various ratios, none with just maltodextrin alone. From what I...
  28. S

    Other Why some feces float and others sink - some bacteria produce more gas than others (Oct 2022, mice) Genesis of fecal floatation is causally linked to gut microbial colonization in mice

    That backronym LIFT is funny, I wonder what it actually means... Though you have to give it to these researchers for studying a topic that is likely to get them laughed at when they present at conferences. It doesn't exactly have disease relevance...
  29. S

    Sources Planning on raising donor payouts to 1 million dollars per stool, and a half-a-million-dollar referral reward (HumanMicrobes.org)

    Out of curiosity, how many clinics/stool banks did you try (with what results) before you decided that they all have awful screening criteria? Or could you not try any because you didn't have C. diff and weren't in the kind of shape to travel?
  30. S

    Sources Planning on raising donor payouts to 1 million dollars per stool, and a half-a-million-dollar referral reward (HumanMicrobes.org)

    Then why isn't SD-ES-2015 ahead in line to be tested over the two other donors who you said, in a private communication, were currently in the process of being activated? I won't list them by name here, as you never said this publicly, but these were two donors who (as far as I can see) have...
  31. S

    Sources Planning on raising donor payouts to 1 million dollars per stool, and a half-a-million-dollar referral reward (HumanMicrobes.org)

    In what sense is SD-ES-2015 "likely the current #1 ranked donor"? Presumably not according to your screening criteria, as in that case you would have prioritized testing this donor ahead of others. Is it according to the percentage of people who tried the donor who were helped? the fact that...
  32. S

    Sources Planning on raising donor payouts to 1 million dollars per stool, and a half-a-million-dollar referral reward (HumanMicrobes.org)

    A 50% success rate isn't bad--IF you can afford to try 4-5 donors. Imagine there were a source offering a deal like this--for $500, you get 10 capsules each from 5 different donors. At $500 for 50 capsules, this is the same price as we're currently getting them at from HMorg. After trying these...
  33. S

    How does pricing work for untested donors (which I see some people have tried)? Do they charge...

    How does pricing work for untested donors (which I see some people have tried)? Do they charge less than fully activated donors, given the greater risk involved? Is it possible that if people agree to pay to have a donor tested, that then the cost of orders is reduced for them given their...
  34. S

    Not nosy as much as giving experiences that might not agree with what the person experienced who...

    Not nosy as much as giving experiences that might not agree with what the person experienced who actually had my kind of profile and benefited from SD-ES-2015. Since SD-ES-2015 is untested, I wouldn't try her until she's been tested. I've already tried UT-AW-1998, so my real question is, for...
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  35. S

    @Fmt2024 there are no posted experience reports at all with either of the unactivated (i.e...

    @Fmt2024 there are no posted experience reports at all with either of the unactivated (i.e. untested) donors who are supposedly pending testing--neither in the spreadsheet nor on the forums. The stool/fitness pictures as well as the questionnaire results are in the longer list, as for the other...
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  36. S

    @Fmt2024 are you zal63 under a different account? The experience report I was referring to was...

    @Fmt2024 are you zal63 under a different account? The experience report I was referring to was by zal63.
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  37. S

    @Fmt2024 Also note that even the longer list doesn't SAY WHICH two are in the process of being...

    @Fmt2024 Also note that even the longer list doesn't SAY WHICH two are in the process of being activated, although they're both on the list. Michael Harrop just told me that in an email.
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  38. S

    Did you see my reply to your experience report on the forums? I'm particularly interested in...

    Did you see my reply to your experience report on the forums? I'm particularly interested in your experiences with the currently active donors FL-RS-1997 and UT-AW-1998, in other words whether one of those two was significantly superior/inferior to the other.
  39. S

    @Fmt2024 The two I mentioned by ID ARE in the spreadsheet. They HAVE been tested, and are...

    @Fmt2024 The two I mentioned by ID ARE in the spreadsheet. They HAVE been tested, and are actively donating. The other two that I have heard are in the process of being tested are not.
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  40. S

    I saw your post about which criteria make a difference when choosing a donor. I wrote my own...

    I saw your post about which criteria make a difference when choosing a donor. I wrote my own thoughts on that here--though like yours, they are based on theorizing/hypotheses and not on actual experience...
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