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  1. Michael Harrop

    FMT Fecal transplant capsules show promising results in clinical trials for multiple types of cancer (Jan 2026, n=20) Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial

    https://medicalxpress.com/news/2026-01-fecal-transplant-capsules-results-clinical.html https://www.nature.com/articles/s41591-025-04183-8 The article also covers this study: Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2...
  2. Michael Harrop

    FMT Evaluation of the efficacy of inactivated fecal transplants against Clostridioides difficile: an in vitro study (Jan 2026) "Inhibition of CD growth was observed exclusively in samples containing live bacteria"

    https://link.springer.com/article/10.1007/s11274-025-04767-z Another study showing live bacteria are required for therapeutic effect.
  3. Michael Harrop

    FMT Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial (Jan 2026, n=40) "results suggest that the elimination of deleterious taxa is required for FMT-mediated therapeutic benefit"

    https://www.nature.com/articles/s41591-025-04186-5
  4. Michael Harrop

    FMT Mechanistic insights into FMT for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial (Jan 2026, n=30) "Colonic FMT was superior to nasogastric delivery - 75% clinical response vs 25%"

    https://academic.oup.com/ecco-jcc/advance-article/doi/10.1093/ecco-jcc/jjag006/8441229 Not much info on the donors, so it seems to be the standard/poor criteria.
  5. Michael Harrop

    How I got off imodium/loperamide. Identify the root cause and the appropriate tool to solve it (FMT, Cholestyramine).

    The OP was correct. The collapse was probably not solely due to stopping the one imodium, but rather, possibly olive oil and another problematic dietary ingredient. This is also because the FMT donor I was using seems weak for restoring bile acid metabolism, microbial density, and clearing or...
  6. Michael Harrop

    The power of olive oil -- significant changes to gut microbiome, stool, and food tolerances

    I think the olive oil intolerance is due to the acids, because the intolerance gets worse when I'm lacking the microbes needed for bile acid metabolism (BAM), and the symptoms are very similar to eating fat without Cholestyramine when my BAM is poor. The side effects I experience from olive oil...
  7. Michael Harrop

    Sources Sourcing FMT. Where to get it?

    There is some related info in this thread: Comparing commercial FMT providers And in the wiki: Where to get FMT
  8. Michael Harrop

    Sources Comparing commercial FMT providers

    You shouldn't be engaging in FMT while still ignorant on such important things. It's covered: In the wiki: https://humanmicrobiome.info/fmt/ https://humanmicrobiome.info/where-to-get-fmt/ In this thread: Continued letters and complaints to the FDA, NIH, and HHS (Jan 2025, FMT) | Human...
  9. Michael Harrop

    Video The false promises of Bryan Johnson and Functional Medicine | The Bryan Johnson "Hit Piece". Surprising revelations in the New York Times put Johnson's integrity into question | Scott Carney

    That means very little regarding safety & efficacy for FMT. https://humanmicrobiome.info/fmt/
  10. Michael Harrop

    Sources Gezonde Darmflora stool donors have diseases as proven by their blood tests?? Wtf??

    This is meaningless nonsense. Please don't post that kind of garbage on this forum. It's also off-topic for this thread.
  11. Michael Harrop

    Enhancing Cryoprotectants for stool/FMT. Capsules, glycerol vs maltodextrin antifreeze, -80 (medical freezer) vs -20 (home freezer)

    Yeah, pretty much.
  12. Michael Harrop

    Article A leading EU chemical safety institute ousted the director of its cancer research center after the director led a testing program into the safety of the pesticide glyphosate, sparking concerns about chemical industry influence into what has been an independent research institution (Jan 2026)

    https://www.thenewlede.org/2026/01/outrage-at-ramazinni-glyphosate/
  13. Michael Harrop

    FMT Replacing microbiota makes aging intestines young again (Jan 2026) Microbiota from young mice restore the function of aged ISCs

    https://www.eurekalert.org/news-releases/1113710 https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00392-3
  14. Michael Harrop

    Outcomes For anyone who has done FMT, did you have worsening symptoms in the few days after?

    Absolutely not. https://humanmicrobiome.info/diet/
  15. Michael Harrop

    Review Environmental pollutants and the gut microbiota: mechanistic links from exposure to systemic disease (Jan 2026) "Increasing evidence reveals that the gut microbiota serves as a central mediator of pollutant-induced physiological dysfunctions"

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1737229/full
  16. Michael Harrop

    Oral Microbes living in our mouths could hold the key to obesity prevention (Jan 2026, n=628) Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity

    https://medicalxpress.com/news/2026-01-microbes-mouths-key-obesity.html https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01591-8 This appears to be correlation only. So it doesn't conflict with prior evidence indicating the gut microbiome is the crux that influences the oral microbiome...
  17. Michael Harrop

    Other Exhaled Breath Carries Disease-associated Bacteria from Gut (Jan 2026, n=41) The gut microbiota shapes the human and murine breath volatilome

    https://respiratory-therapy.com/disorders-diseases/infectious-diseases/other-infections/exhaled-breath-carries-disease-associated-bacteria-from-gut/ https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00544-3
  18. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    Because they're regurgitating things they've read that sound plausible.
  19. Michael Harrop

    Procedure DIY FMT Beginner's Questions

    I typically use 10 lbs of dry ice in case there's a delay.
  20. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Bryan Johnson, I presume. It's been discussed in other threads. It appears his interest is in selling his own stool.
  21. Michael Harrop

    Outcomes For anyone who has done FMT, did you have worsening symptoms in the few days after?

    I don't think so. I would lean towards it being a bad donor.
  22. Michael Harrop

    Sources I am considering going to IPPM clinic to do an FMT. Would you do it?

    There are no good sources of FMT because people are too lazy to take necessary action to remedy the situation.
  23. Michael Harrop

    Video The false promises of Bryan Johnson and Functional Medicine | The Bryan Johnson "Hit Piece". Surprising revelations in the New York Times put Johnson's integrity into question | Scott Carney

    Someone shared this article with me: https://zoe.com/learn/the-man-who-wants-to-live-forever-bryan-johnson. It shows that Bryan Johnson's main interest in FMT is in selling his own poop, or a supplement made from it.
  24. Michael Harrop

    Outcomes For anyone who has done FMT, did you have worsening symptoms in the few days after?

    In my experience, some donors can trigger an initial day-or-so of worsening symptoms before seeing subsequent improvements. With bad donors, they can worsen symptoms and cause new ones, and the symptoms don't go away. It can be difficult to immediately determine which is which. Adequate...
  25. Michael Harrop

    Sources Gezonde Darmflora stool donors have diseases as proven by their blood tests?? Wtf??

    Gezonde Darmflora is already covered in the wiki as a known poor source, so I'm not sure why you seem to have been counting on them. https://humanmicrobiome.info/where-to-get-fmt/ I haven't looked at their tests, but those kinds of blood tests can show current or prior infection. So be sure you...
  26. Michael Harrop

    Study Tiny RNA molecules in sperm have big impact on baby health. Findings provide strong evidence for epigenetic inheritance of paternal environmental effects (Oct 2025) Epididymal dynamics and preimplantation roles of a sperm-enriched 5′ fragment of tRNA-valine

    https://news.ucsc.edu/2026/01/tiny-rna-epigenetic-inheritance/ https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01137-4
  27. Michael Harrop

    FMT Washed microbiota transplantation relieves atopic dermatitis via gut–skin microbiome rebalancing (Jan 2026, n=23)

    https://www.hmpgloballearningnetwork.com/site/thederm/news/washed-microbiota-transplantation-improves-disease-severity-and-microbial https://link.springer.com/article/10.1186/s12866-026-04717-1
  28. Michael Harrop

    Antibiotics The aggressive use of antibiotics could fuel mood disorders and anxiety (Dec 2025, n=175) Consistent decline of acetylcholine in microbiota-gut-brain axis mediates antibiotic-induced anxiety via regulating hippocampus microglial activation

    https://medicalxpress.com/news/2026-01-aggressive-antibiotics-fuel-mood-disorders.html https://www.nature.com/articles/s41380-025-03431-0
  29. Michael Harrop

    Early development The maternal microbiome influence on pregnancy success: breeding comparison of germ-free and conventionalized mice (Jan 2026) "We observed unexpectedly high maternal and offspring mortality in GF animals. Maternal microbiota might influence offspring health far earlier than previously recognized"

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2609405
  30. Michael Harrop

    Article A bombshell’: doubt cast on discovery of microplastics throughout human body (Jan 2026) Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’

    https://www.theguardian.com/environment/2026/jan/13/microplastics-human-body-doubt
  31. Michael Harrop

    Other Why FMT specifically? Why focus on the colon microbiota, wouldn't it be better to transplant microbes from every part of the body that they are found in?

    That seems to largely be the case, but I don't think the research is conclusive.
  32. Michael Harrop

    Other Why FMT specifically? Why focus on the colon microbiota, wouldn't it be better to transplant microbes from every part of the body that they are found in?

    Poop contains microbes from the entire digestive tract, including oral microbes. There are different percentages of microbes at different body sites due to the different environments. [1] When you transplant stool into another body site, the percentages of microbes will change due to the...
  33. Michael Harrop

    General health Using AI chatbots for medical advice

    AI chatbots may seem useful, but they are not reliable at all. They are prediction engines that predict the words most likely to come next, based on the data they've been fed (which is often very flawed). They often "hallucinate" or make things up.
  34. Michael Harrop

    FMT A man with auto-brewery syndrome gets relief from faecal transplant (Jan 2026, n=22) Gut microbial ethanol metabolism contributes to auto-brewery syndrome in an observational cohort

    https://www.newscientist.com/article/2510789-man-whose-gut-made-its-own-alcohol-gets-relief-from-faecal-transplant/ https://www.nature.com/articles/s41564-025-02225-y
  35. Michael Harrop

    Other The secret to human intelligence? It might be in our gut. Your gut microbes may have helped build the human brain—and could still be shaping how it works today (Jan 2026) Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment

    https://www.sciencedaily.com/releases/2026/01/260105165806.htm https://scitechdaily.com/your-gut-microbes-may-be-quietly-transforming-how-your-brain-works/ https://www.pnas.org/doi/10.1073/pnas.2426232122
  36. Michael Harrop

    Other Vaginal and gut microbiome dysbiosis linked to endometriosis (Dec 2025, n=22) Comprehensive Analysis of Vaginal and Gut Microbiome Alterations in Endometriosis Patients

    https://www.contemporaryobgyn.net/view/vaginal-and-gut-microbiome-dysbiosis-linked-to-endometriosis https://www.dovepress.com/comprehensive-analysis-of-vaginal-and-gut-microbiome-alterations-in-en-peer-reviewed-fulltext-article-IJWH I've contacted lots of women with endometriosis about this...
  37. Michael Harrop

    Causation A molecule produced by gut bacteria can trigger atherosclerosis (Jul 2025, n=400) Imidazole propionate is a driver and therapeutic target in atherosclerosis

    https://www.gutmicrobiotaforhealth.com/scientists-discover-that-a-gut-microbiota-molecule-causes-atherosclerosis/ https://www.nature.com/articles/s41586-025-09263-w
  38. Michael Harrop

    How does regular valtrex use impact microbiome?

    For that kind of thing, you can search pubmed or google scholar for "[drug name] microbiome". Valtrex is an antiviral, so not something I'd be especially concerned about when it comes to the microbiome.
  39. Michael Harrop

    What's wrong with my gut?

    Virtually everything you're inquiring about is covered in the wiki. FMT is the primary solution. You can use a site like https://examine.com/ to look up evidence for supplements & conditions. This is unlikely to be a solution due to donor quality problems...
  40. Michael Harrop

    Other Pesticides and other common chemical pollutants are toxic to our ‘good’ gut bacteria (Nov 2025) Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro

    https://www.cam.ac.uk/research/news/pesticides-and-other-common-chemical-pollutants-are-toxic-to-our-good-gut-bacteria https://www.nature.com/articles/s41564-025-02182-6
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