Yes exactly.
The difference between the early symptoms and the stretching sensation was that the early symptoms were relatively constant while they existed, but temporary, lasting only a day or two of the treatment, whereas the gut stretching came on immediately after each new dose and was...
Three days is probably too short, I find that it takes around 5 days for almost any change (dietary, antibiotics, etc.) to reach its full impact on the gut, sometimes to have any impact. Occasionally before that there's somewhat of a "die-off" type reaction, where I feel more tired, have a bit...
I second wanting to know what the goals are now. I have been operating the whole time under the assumption that what we're all trying to do is first to identify characteristics of effective donors through experimentation and then to make treatments from those donors available to patients.
I...
In that case rifaximin may just do nothing for you, unless you've had a reasonably curative FMT in between (in my case, I'd worsened again after a FMT and rifaximin temporarily brought much of the lost benefit back).
I don't remember, have you been on long courses of heavy antibiotics before?
My gut issues started with years of rotating antibiotics of various classes. After that, taking rifaximin just literally did nothing, even after multiple courses. It didn't hurt, but also didn't help.
If you don't...
No but I was told I needed to feed the microbes because rifaximin kills them better when they are actively dividing, so I basically ate whatever I wanted (i.e. however much FODMAPS, sugars, etc.), except for the foods I had been allergic to for life, while on it rather than sticking to the...
A while back you were talking about wanting to get clinical trials of your donors vs. other donors. Though presumably given the fact that you aren't a doctor, you were talking about having other people do the trials, but that doesn't mean funding is unnecessary, rather it means that you'd be...
If you have found multiple donors good enough for a near-complete cure, then I'd gather that you're nearly completely cured? If so, why are you still looking for more donors? Are you looking to go from "nearly completely" cured to "completely" cured? Or are you accepting that the donors who you...
Back when Human Microbes was still operating, there used to be a donor list with questionnaires from each donor as well as stool pictures. Michael used to have each prospective donor send a series of stool pictures from different days and determined whether to test them based on that as well as...
The two most worth commenting-on aspects of this work are (IMO):
A) They did not measure ANY markers of host metabolism or function at all. Not weight gain or loss, blood lipid levels, nothing. So when they speak of "response", they are SOLELY referring to how close the post-FMT samples of the...
It's difficult to do that concisely because most antibiotic susceptibility charts are geared towards infecting systemic pathogens, not the microbiome. If you're curious about a particular species in the microbiome you basically have to look up its antibiotic susceptibility individually. However...
That's why I said temporary improvement. Vancomycin is certainly NOT a cure by itself and I didn't mean to imply so.
It's also important to clarify that if any benefit of vancomycin pretreatment DOES exist as shown by studies, it would NOT be safe to conclude that any of the other antibiotics...
Hopefully we will hear about this soon. I suspect that vancomycin pretreatment is important and helpful, given the fact that vancomycin alone can be temporarily helpful for some patients, but I'd like to have actual data.
I agree on the strength of FMTs in general and the potential of changes for up to two months.
It does seem as though UT-AW-1998 was a better match for this recipient than FL-RS-1997 especially for systemic (non-gut) symptoms. The suppression of diarrhea by the FL-RS capsules doesn't seem to...
Why would that be funny? If he found success from something else, that's worth all of us finding out about. If the farther he got from FMT the worse he got, that's also not funny, that's tragic.