Recent content by SFBayFMT5

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    Causation Very interesting paper about metabolic roles in the gut microbiome (August 2024, human) A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people

    Just wanted to report that this is no longer just a preprint! I don't know how I missed this, I was checking back periodically every few months for quite a while since I first saw this paper and it never had progressed past BioRxiv. Turns out it's been published since October of last year...
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    Sources Is HumanMicrobes.org legit? Is it a scam? Are they really paying $500 for stool donation? Misinformation & fake reviews on reddit.

    I have to wonder why you are responding now on here to threads posted on Reddit three years ago. I can only speculate that you have gotten feedback from people through your activism in DC that these negatively toned threads are affecting their opinion of your intentions and/or willingness to get...
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    Parasites An anti-parasitic medication (ivermectin) shifted Amazonian villagers’ microbiomes toward an urban profile (May 2026, n=335) Rapid microbiome restructuring associated with medical exposure in remote Amazonian Indigenous communities

    It seems to me that the authors of the first paper are not arguing that it is specifically the ivermectin that caused the changes, but rather "contact with the modern medical system". I agree this is a weird way to describe it (at least, I gather from how you present this that you also think...
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    Blog Fuck Portion Control by Nathan Guy Hatch

    I only had to read this much to figure out that this person is a loon. Electrons are constrained in the ETC by 1) the proper folding of its proteins, which fully surround the electron carriers except in places where electrons are designed to get in or out, and 2) the membrane lipids, which are...
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    I very much agree with the point overall, but this isn't strictly true. C-section is a surgery and so it has risks that don't occur with non-surgical birth. One would need to look at the likelihood of complications of vaginal birth in various environments with different levels of infection...
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    Sources Does anyone have any experience with Microbiota Therapeutics at UMN (University of Minnesota)?

    Likely because they're only interested if you're either a hospital or a researcher coming to them with a clinical trial proposal. It likely has nothing to do with them being a good or bad source (though the failure for C. diff implies they're not a very good one at all) but rather that they have...
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    FMT Towards a Standard Protocol for Fecal Microbiota Transplantation in Irritable Bowel Syndrome [meta-analysis/summary, Apr 2026]

    This was recently published. It's not a new study, rather it summarizes the current state of knowledge and experience. In a number of cases it addresses things that Michael, myself, or others posting online have noticed but that I haven't noticed being mentioned before...
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    Procedure Looking for advice on autologous FMT

    It's mostly eliminated through the urine so it shouldn't have. The only thing about beta-lactams like amoxicillin that works against you is that they're bactericidal, i.e. they actually kill bacteria rather than just stop them from growing. Thus if you did get amoxicillin into a bodily fluid...
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    Procedure Looking for advice on autologous FMT

    Makes perfect sense, this is one of those times when the cost of NOT taking abx is worse than the potential damage to the microbiome. You wouldn't have wanted to wait until you had a life-threatening infection to start taking them. I hope for you that this is the case. It's not impossible that...
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    Though only for microbiota-based treatments it seems. The number of drugs that have been approved without knowing how they work is quite large. There is still controversy over how Tylenol works of all things. It's less common now mostly because most research programs that find new drugs start...
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    The last quote also speaks to an important point that holds for fecal and oral transplants as well: In other words, it's important to learn how transplants work insofar as it makes them able to potentially be performed more successfully, safely, and/or cheaply (for example, if allows...
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    Indeed. It's remarkable that not only can this lipid cross the skin barrier, which is generally quite impermeable to anything larger than, e.g. gases, but also apparently the blood-brain barrier. I'd never have imagined that a compound likely made in relatively small amounts (it's not a central...
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    Other Where can I buy empty enteric-coated capsules for FMT in Europe/Sweden?

    I assume you've looked on Amazon and similar shopping sites? When I was ordering them I found a supplier with not too much trouble, though they're in the US and therefore shipping to Sweden is probably quite expensive from them. I imagine if you search from an account or IP address based in...
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    Causation A widely distributed gene cluster compensates for uricase loss in hominids (Aug 2023, mice + retrospective analysis of human data, n=30 to n=6573)

    Since my last post on the oral transplants where I was saying things were starting to fluctuate, I started getting kidney pain and felt as though I were beginning to pass a stone. I knew I had some asymptomatic ones in there for years but none had ever gotten stuck and caused acute pain until...
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    Sources Comparing commercial FMT providers

    Looking through the spreadsheet again just now, I see quite a few more people who mentioned having tried non-HM donors (and even other HM donors) prior to the donor that their entry in the spreadsheet is about than I recall seeing when reading the same spreadsheet in 2024. That's definitely...
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