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  1. S

    Comparative study of H pylori and Streptococcus anginosus on genomes based

    You might be better off asking in a computational biology forum like Biostars or r/bioinformatics, but what are you looking to do? Are you looking to take genomes of new strains that lack gene annotations and find genes in there? or is knowing the pathways from the genomes of reference strains...
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    State of microbiome-based therapies 5-10 years from now?

    The microbiome DOES have a profound effect on mental, in addition to just physical health. However, not in the way you imagine if you are seriously asking yourself questions like this. I thought of this before my very first FMT (and before some other interventions before that)--I am on the...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    The thing is, their hands are tied as well (in the US). Doctors and other medical professionals who promote FMT for conditions other than C. diff risk disciplinary action up to eventually losing their medical licenses if they persist. By "promote" here I mean not just to state they believe in...
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    Gezonde Darmflora Extreemly bad experience with Df4 from Gezonde Darmflora

    Nobody is saying your experience wasn't true. We just didn't have enough information to evaluate your experience. Now I see from your updated title that you used DF4. I, and all the people I've known who tried GD, used either DF3 and/or DF7. The latter helped me, but not fully--the former made...
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    Gezonde Darmflora Extreemly bad experience with Df4 from Gezonde Darmflora

    Which donor was this?
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    Early development Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort (Mar 2025, n=36)

    It's interesting that they only found bacteria negatively associated with normal development, and none positively associated. However they found increased diversity associated with normal development, which suggests that maybe normal development is promoted by a large variety of different...
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    Procedure DIY FMT Beginner's Questions

    Just to add something to 2: In my case, improvement continues for at least a month if not longer after FMT. After my most successful FMT, there were a number of clear immediate (same day/week, this was an endoscopy procedure) changes, but the most dramatic changes happened right around the six...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    I do see that you already cite this 2018 in your probiotic page--good for you! But do you mean you had already concluded this BEFORE 2018? If so, was it based on an even earlier study, or simply on your own experience and testimonials from other patients? If the latter, then you do deserve...
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    FMT FDA sent MG Infusions a warning letter; website is down. (Mar 2025)

    "I see that they do send warning letters to people outside the US." What force does this have? Does this mean that if the foreign seller doesn't comply, that anything coming into the US from such a seller will be seized and destroyed? In any case, this obviously confirms the FDA is back up and...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Also, did you see the reference about probiotics cited in that article (Ref #2)? I only noticed it just now, but it's informative. The conclusion of that one was that probiotics actually delay recovery of the gut microbiome after antibiotics, relative to taking nothing except the antibiotics...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Too late for us whose guts are already messed up, but hopefully this will be around for patients in the future! It's an engineered strain of yeast that destroys antibiotics in the gut before they have a chance to deplete the intestinal microbiome.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    So basically he is concerned with health care, or at least claims to be, but only so far as to help people afford conventional treatments like pharmaceuticals? Rather than accuse people of being frauds, your message should be that there is an effective treatment that is banned by the...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is that relevant to FMT? I'm assuming this was a hearing relating to health policy? If so, getting the serious attention of anyone in those hearings could be a win, even if it's only a few people. If this hearing was on an unrelated topic, then obviously it wasn't a good place to bring up...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is the campaigning in DC going?
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    The group is just called "Fecal Microbiota Transplantation".

    The group is just called "Fecal Microbiota Transplantation".
    • SFBayFMT5
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Sure EvaJak. These FMTs were the latest in a series that I started last May, so you may want to read my previous review of HM (in which I also compare and contrast that with OpenBiome). But briefly, this whole thing started with a sort of stretching pain in my middle back and a visibly swollen...
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Firstly, how do you know it's even the same woman we are talking about? Secondly, much of my interaction with her was in private messages, it was not public. Not to say that what she said publicly was in any way lacking in transparency either mind you--just that if she didn't spell everything...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    That site has "scam" written all over it! Lots of very good sounding but completely vague verbiage and no actual work they are doing.
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    It was the man, not the woman, who was evasive. The woman was very forthcoming about exactly how she had done her FMTs and what her experience was. She however ONLY used DF3, which was the donor who made me worse. The man had used both. This third study is about frozen FMT vs. FMT that has...
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Firstly--so Gezonde Darmflora (who I will call GD from now on) went through a period earlier this winter of not accepting orders from the US due to customs issues--thankfully neither of my orders had this problem although other orders in the same time frame did. Now they have solved this problem...
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    Outcomes Body odor changes after FMT?

    -do you get the same body odor as your donor after a lot of fmts? or is it more of a temporary effect that's gone as soon as you finish the fmts? I have not smelled the body odor of any donors as I do not know any of them personally. I also haven't noticed major shifts in my BODY odor after FMT...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I just wrote to Senator Cassidy last night
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    Just last night I posted a very recent (in fact, not yet formally published in a journal) paper...

    Just last night I posted a very recent (in fact, not yet formally published in a journal) paper in the "Microbiome studies, news, media" section that you might really like to read. You ask a lot of questions about the microbiome and how it functions biochemically, that's what this paper is all...
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    Question GutID Microbiome Test

    In what way were you not impressed with Viome's results? Did they indicate your gut was "normal" despite you feeling very poor? That's how Thryve (now Ombre) was for me. I read about GutID and it seems the chief advantage they claim is that they identify bacteria down to the strain level...
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    Sources Comparing commercial FMT providers

    I mean that there is no way to compare PROVIDERS without receiving data from people who have tried more than one. Saying merely that of five people who ONLY tried Microbioma, for instance, only two improved, while of four who ONLY tried Gezonde Darmflora, all four improved, doesn't necessarily...
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    Causation Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal flora (Feb 2025, mice)

    It looks like at least the abstract was run through an automated translation software of some kind, because some incorrect interpretations of terms have been added. In particular, I assume that "F/B ratio" in the original paper is referring to the Firmicutes/Bacteroidetes ratio, but the software...
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    Causation Very interesting paper about metabolic roles in the gut microbiome (August 2024, preprint only, human) A widespread hydrogenase drives fermentative growth of gut bacteria in healthy people

    I was excited to see this paper a little under a month ago, as it confirms some things I've been using as a working assumption for a long time, yet never actually seen any empirical evidence for. The paper is only a preprint (i.e., an article that hasn't made it into an actual journal yet) now...
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    Sources Comparing commercial FMT providers

    "Other people make brief comments here and there"--that gives no basis to evaluate the overall success rate of any provider. What you really need is to look for people who have tried more than one provider. Clearly there are people for whom finding the right provider and/or donor is MUCH harder...
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    Early development Maternal allergy status, infant birth season impact milk microbiome of mothers (Dec 2024, n=196) Maternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk Microbiome

    Interesting! So maybe it's time for a "microbiome zodiac" lol. While I'm sure that environmental bacteria vary significantly across the seasons, I would have thought that the human host environment would have buffered a lot of that, especially in modern Western cultures where food...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    What I mean by tone is this... in a number of your posts, you come across as if you believe the following: 1. The FMTs you have sold are so much superior to FMTs from ANY other provider, that anyone who uses a different provider is wasting his or her time 2. Building off point 1, you have...
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    Human Microbes Extreme Success From SD_ES_2015 For Severe Anxiety, Depression, and IBS

    The way I read the OP, I understood it that this is the most compatible donor of the four that he/she has tried, BUT even then, it STILL required a combination of thawed AND unthawed to be dramatically effective.
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I guess it's just a bad picture then. Hopefully the same goes for his general tone about other people, the state of the world, and the role of his own work in the whole thing. It's possible he mostly posts here when he needs to rant.
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    Outcomes Please help - anxiety/panic after FMT+yellow stool

    It sounds like whoever you used was a poor match donor for you. The one donor I've tried who made me worse, it was a similar thing, it greatly flared my mental health issues (whereas good donors improve them--and my best donor, from OpenBiome, temporarily got my mental health the best it had...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I challenge you to observe the people you see around yourself when you are in DC, and count how many have hair so long that almost their entire foreheads are invisible due to being covered by hair. I made a point of observing people I walked/drove by the day I made my last post, and I didn't see...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I don't know if it's the beard by itself, or the general vibe that the entirety of your appearance gives off. In the picture of you in front of Bernie Sanders' office, the combination of the beard, the slightly wild hair that hangs down over your forehead, and the wide-eyed stare make you look...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    By the way, someone in a FMT group just mentioned this clinic in Portland, and I see they do autologous stool banking: https://drcarmencampbell.com/aboutme/. So this is a definite option if you want to do what I was saying above (save some of your microbiome prior to going on antibiotics). I...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    The opposite is true--autologous FMT will NOT restore critical species or strains that are entirely missing (unless the stool is collected before whatever stress--e.g. antibiotics--causes them to go extinct in your gut). Yes this concept IS correct. Each species of bacteria has certain...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I'm surprised as well that Bernie Sanders was dismissive of FMTs (or at least, that he was MORE dismissive than the average politician--even if ALL politicians almost HAVE to be dismissive of most things in order to make use of their limited time). He seems like a remnant of the 60s...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    In my opinion, FMT is FAR too much of a gamble to be valuable if you have no health issues! In other words, it isn't something you do that's comparable to taking a bit of extra B vitamins or adding more leafy greens to your diet. Yes, for those of us with intractable health issues it can be an...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    Yes, this is VERY different. Autologous FMT taken from before one's current health issues started is definitely promising. In fact, this might be even MORE likely to work than FMT from an unrelated donor, whose microbes may not be compatible (in other words, that person's "normal" might not be...
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