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  1. S

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    They have been pulled from the schedule quite clearly for political reasons, NOT because there are any new scientific findings negating the favorable benefit/risk ratio. I support anyone being able to choose to get or not get this vaccine, but I'm not going to buy into politicians' judgments on...
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    Other What exactly is forbidden in the US with regards to FMT?

    So from the Science Forums thread it appears as if Rebyota can be used off-label--so shouldn't we be encouraging medical practices to go into the area of prescribing it for patients with damaged microbiomes? Back when I was undergoing Lyme treatment, there were a lot of questionable independent...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    I certainly am not ignoring it. My question though is, how can we band together and do some kind of community outreach to find the people who AREN'T turned off by this. Michael is trying to do this on a national scale, which is commendable--but if we all banded together to help each other find...
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    Other What exactly is forbidden in the US with regards to FMT?

    Ok so FMT IS considered "a drug" even when it is not manufactured by a pharmaceutical company. Are you referring here to your inability to recruit effective donors paying them as much as you did before? So it does seem like you would need to remove all mention of FMT then.
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    Other What exactly is forbidden in the US with regards to FMT?

    Some comments in the recent thread on Scienceforums.org made me think to ask this question. It's relevant to how exactly FMT products can or cannot be marketed in the USA, and hence to how a successor to Human Microbes would need to operate. People there were claiming that FMT is merely not...
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    Article Finch wins US jury trial against Ferring over fecal-transplant patents (Aug 2024, Rebyota)

    Their latest clinical trial mentions a "full spectrum" microbiome therapeutic, which would support this: https://pubmed.ncbi.nlm.nih.gov/39366468/ The question I would have is, what's the difference between the various products in their pipeline (CP101, FIN-524, FIN-525, FIN-211)? Are some of...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    That's just it. I ASSUME that ANY provider of FMT will have recipients who have gotten worse from certain donors. Even OpenBiome, whose FMT did more than Gezonde Darmflora and Human Microbes combined, with fewer side effects, has negative experiences, as Michael has posted here about before...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    I don't need to trust, or NOT trust, anything that Marco said to know how I reacted to DF3, and how different it was from how I reacted to her brother DF7. It was not Marco who in any way raised the possibility that it would extend to other females of her age--it's just me being a scientist and...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Anyone who isn't liberally biased is going to associate FMT with "experimental dangerous medicine that doesn't work" if it gets associated with anyone liberal who pushed the covid vaccines. One could go the other way though and say that anyone who seriously thinks the COVID vaccines are a prime...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    I think we ARE talking a completely different language. The only thing I care about right now is finding new donors. Therefore the only question that's relevant to me about DF3 is how it could inform my future choice of donors. For instance, would someone who does poorly with her also react...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    It seems the most likely would be if there's a podcast about DIY science, biohacking, etc. Appearing on a podcast that is already controversial for politics seems like it could really backfire--I wouldn't want FMT associated in the least with radical anti-vax, QAnon, or any other fringe...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    I'm very confused now. You said, in your own words, "I also had benefits from this donor in some other areas. It got rid of my brainfog for 90% and helped against my severe bloating." This is, as I understand, pertaining to DF5. And you said that "Before that I had normal stool on the...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    Umm... so now you're agreeing with the people who have been telling you that it's too experimental and has major risks? Again... so you're now agreeing that disgust is one of the main factors, when you have spent about five posts trying to convince us why it's insignificant in the larger...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    Just some points of clarification, as I suspect some people may misunderstand parts of the above--I'm NOT implying that FMT recipients mistreat donors in any way, or even tend to. Most of us are very nice to donors who we actually feel are promising, and very "down to earth" in our expectations...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    In one of the Reddit threads you link, someone ("WalterBishRedLicrish") said the following: This seems to be exactly the sort of thing that NameHere was saying, and I have been noticing. There seems to be a strong aversion among many people to the idea of using something from a healthy...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    The difference is that biology has noise and variability that the physics of flight doesn't. A machine either flies or it doesn't, whereas a "drug" that ISN'T actually a drug at all will help some people by the placebo effect, and an actually very effective drug will fail for some people. The...
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    Blog First results from our 1 in 23,000 stool donor (2022, HumanMicrobes.org)

    The thing is that for some of us we've had a FMT experience that WAS a "holy grail" for them. If you present it as "it's cruel to deny people something that worked for them in the past just because it isn't 'proven' (where that necessarily implies a population, rather than an individual)", then...
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    Blog First results from our 1 in 23,000 stool donor (2022, HumanMicrobes.org)

    Ummm... wasn't the whole thread (the one you removed these posts from) about how every Congressperson you stop in the hallway and ask about FMT, or nearly every one who you try to set up an actual one-on-one meeting with to discuss FMT, ignores you and goes right back to whatever they were doing...
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    Blog First results from our 1 in 23,000 stool donor (2022, HumanMicrobes.org)

    How are you so sure that this is not simply a function of who responds to you, rather than how the majority of people feel? In my experience, people (at least neurotypical ones) who are grossed out or creeped out by ideas react to this by ignoring the people who make them feel that way, without...
  20. S

    Blog First results from our 1 in 23,000 stool donor (2022, HumanMicrobes.org)

    This is totally it. Someone I know who is looking for a donor posted on a forum for residents of a town near her, asking for donors, and some people were apparently downright RUDE to her. I just saw one that hinted sideways that he was questioning whether she might be some kind of pervert, but...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    LOL! I guess now you need a colonic with water filtered to a very high standard of gender purity in order to decontaminate your gut from any transgender microbes that your system may have been inadvertently exposed to! Next thing you know some of the Gram positives are going to start dressing in...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    To be clear, what happened to me with DF3 is not likely something that would show on a stool or blood test. It's not that I picked up a disease from her, it's that the proportions of bacteria in her stool were far too stimulating for my system, both for my gut (causing diarrhea) and my brain...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    I reported my success with them here: https://forum.humanmicrobiome.info/threads/temporary-success-with-openbiome-in-2015-for-post-lyme-and-neuropsychi.358/ FYI they are no longer operating. They also only provided FMT for C. diff while they WERE operating. You can find other mention of them...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    Good to know that too about Microbioma. Though the situation with the Microbioma donors is confusing, I can never keep straight who is talking about whom. Because some people said there was one male donor and one female, some said there were originally two male donors but then they got a third...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    I don't see how using AI in this way would provide any more information than one would get by merely searching the literature using a conventional search engine. LLMs have pretty conclusively demonstrated their inability to rank the relative credibility of sources better than a human could...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    Good too see someone else had a similar worsening from DF3, so it's not "just me". Not in the sense that it's good to see people get worse, but in that it's not that I am the only one made worse by a donor who is great for everyone else. It's also interesting to see that DF5, who Marco said was...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    Does it return ONLY that study though, or (as I would suspect) that study in a long list of other studies? The factor at play here is nothing to do with censorship. It has to do with the models associating collection of words in a certain order. The model doesn't actually know what "curing...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    Why would this have anything to do with being "censored" or not? AI "censoring" relates to the prevention of the model returning unethical, bigoted, or harmful (i.e. advocacy of suicide and/or violence) outputs, or in the case of image models, generating NSFW images. I have never heard of an AI...
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    Article Finch wins US jury trial against Ferring over fecal-transplant patents (Aug 2024, Rebyota)

    From the prescribing information, "Description" (Section 11): https://www.ferringusa.com/wp-content/uploads/sites/12/2022/12/9009000002_REBYOTA-PI_11-2022.pdf "REBYOTA (fecal microbiota, live – jslm) is an opaque fecal microbiota suspension for rectal administration. REBYOTA is manufactured...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    This sounds like complete empty hype. There have been data-driven, machine learning-based predictors for toxicity, oral absorption and blood brain barrier permeability, stability in blood, and similar ADME-type measures for years, and these haven't really made much of a difference in the amount...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    How long did the benefit last from the garlic and oregano? My experience with things that kill bacteria (whether antibiotics or herbs) is that even if they cause a change in the beginning, that change is lost within a week or so, even if I continue taking the medication or supplement (or go back...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    It would be GREAT if more of the scientific community started talking about gut bacteria "for real" as you put it. But if the conclusions are what you are imagining (that specific species are "blamed" for diseases, as opposed to the lack of certain species causing diseases), then the cure that...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I have heard secondary reports of "Lactobacillus SIBO" where the only organism found in greater-than-normal numbers in the small intestine is a species of Lactobacillus (i.e. no significant elevation in any Enterobacteriaceae, Streptococcus, Bacteroides etc.) but never any literature. I...
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    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    How would you know, since you only test your donors once? All Gezonde Darmflora donors except for DF6, their newest donor, have failed a stool test at one time or another, since they are tested monthly--however their overall probability of testing positive on any given test is low. Most months...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I watched that video and I think I see what's going on. There's a lot of that in the science communication world. Basically, it's an alliance of science and a very "conservative" type of "alternative" health, where researchers come out and act as if they are starting "a revolution" when in fact...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I think what we're running up against is a sort of "Catch 22" where most people don't try FMT because it's not readily available, and so then you don't have huge groups of people with success stories to tell who would sign petitions like this. Add to that the fact that even among those who DO...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    First the good: I REALLY appreciate the attempt to include a broader range of bacterial diversity (both genetic and functional) than the vast majority of other probiotics. We have one sugar fermenting lactic acid bacterium (Enterococcus), one "secondary fermenter" that utilizes the lactate...
  38. S

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Who is most important for us to contact at this point?
  39. S

    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    “There are microbes along the entire intestinal tract, and we just study predominately the last third of it (the colon),” DeLeon said. I've been saying this for years as well! That almost the entire research on the gut is focused on the large intestine, which in turn means largely on just two...
  40. S

    Early development In utero human intestine contains maternally derived bacterial metabolites (May 2025, n=21)

    From the very first sentence of the Methods section: "Placental and fetal samples were obtained from the University of Pittsburgh Biospecimen Core from electively terminated products of conception (14–23 weeks of gestation)" So indigo34 was correct--these were aborted fetuses.
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