Recent content by Otto Kretschmer

  1. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Neil deGrasse Tyson (the spiritual successor of Carl Sagan) covered the gut-brain axis in a StarTalk episode a month ago, the video had 320,000 views as of now. Perhaps you could at least try to contact him? https://www.youtube.com/watch?v=fIeVrVm1W1A
  2. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Nothing can translate into a widely used therapy until phase 3 trials are completed - and they cost a lot.
  3. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    A few months ago I read an article from 2019 about Alzheimer's research - progress got stalled by 10-15 years simply because senior researchers refused to fund or publish ANYTHING that wasn't about amyloid. And it shows quite clearly that even among scientists, a group expected to be highly open...
  4. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    To be specific, I would gladly accept more FMT research regardless of what political background it comes from.
  5. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Will there even be money for clinical trials? I don't follow US domestic politics but I do know that there have been massive budget cuts to scientific research in the US - including $2.7 bln cuts to NIH funded research. They have the potential to make the whole US science moribund.
  6. O

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Personally I wouldn't expect much from RFK Jr given that he is a nearly stereotypical crank. Even leaving aside his usual anti vaxx stuff, he holds a lot of other idiotic beliefs HIV denialism denial of the link between UV exposure and skin cancer, detoxification BS (belief that diseases...
  7. O

    Causation The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study (Apr 2025)

    That's... intriguing. While I know a lot about the potential of gut microbes to treat a vast range of diseases - I am much less informed about it's potential to treat diseases like mine - and even less so about the role of the immune system in it.
  8. O

    Causation The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study (Apr 2025)

    I have poor eyesight due to Retinopathy of Prematurity - retinal scarring limits my visual resolution since my brain has to construct image from a smaller amount of information. I just doubt gut microbiome manipulation could help me as retinal cells don't regenerate :(
  9. O

    Other An imbalance of gut metabolites in children with autism disrupts neurotransmitter production, influencing behavioral symptoms (Apr 2025, n=84) Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology

    Another autism study, nice! I would like to do some personality and cognitive optimization of myself and I am frustrated how slow the pace of development is. The standard of care for Neuroticism are the SSRIs which were introduced in 1987, the same year Amiga 500 was released. Can you imagine...
  10. O

    Causation The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis (Sep 2024)

    I wonder what microorganisms might influence visuospatial memory? I have poor visuospatial memory which makes it hard for me to memorize streets and Chinese characters. My background - a premie born 2 months too soon. I suffered 2 bouts of pneumonia in an ICU due to de facto medical negligence...
  11. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Have you tried contacting doctors who might help you popularize FMT? They might be more open minded than politicians and they have more authority than random people like us.
  12. O

    State of microbiome-based therapies 5-10 years from now?

    @Michael Harrop I would do FMT some 3-5 years from now but I have some doubts: While there are certain traits like emotional stability, working and visuospatial memory, which I'd like to improve, there are others that I very clearly don't want to change I don't want to lose my extreme...
  13. O

    State of microbiome-based therapies 5-10 years from now?

    What will be the state of affairs in the field in 5-10 years? Especially in cognitive and mental health? Will FMT still be a thing or perhaps newer, better therapies will be available? I am not overall unhealthy and I would rate my personality at 6.5/10 and my cognitive health at 7/10 at age...
  14. O

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    @Michael Harrop Sorry to say this but you've probably already lost your battle :( Research (conducted in the US itself) says that what bottom 90% of Americans want has zero influence on actual US government policies. The top 10% is much more influential...
Back
Top