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Thanks for the detailed review!! Can you provide the name of the FB group? I am trying to find some reviews for a place that will ship to the US.
Just last night I posted a very recent (in fact, not yet formally published in a journal) paper in the "Microbiome studies, news, media" section that you might really like to read. You ask a lot of questions about the microbiome and how it functions biochemically, that's what this paper is all about.
My name is Nick, and today I discovered what FMT is. WOW that’s awesome! I just watched the YouTube video of “Your poop could save someone’s life” and I thought to myself, is it that easy? Could I possibly help someone? What if I needed this kind of help someday? What if my own poop now, could potentially save my own life later? Could I save someone’s in my family someday? And the list of questions just kept running through my head. So, what I’m asking is, how can I help? What do I need to do to see if I’m a suitable candidate to offer my feces? Definitely worth the ask if I could save a life or potentially my own someday.

Thanks,
Nick
I am a United States Army Aviation Ranger Veteran. A wife, mother and grandmother plus designer.

I recently took the online challenge for gut health to get rid of parasites from the body with the WILDCRAFTED JAMIACAN DUCK FLOWER.. WHEN I SAY NOT A DARN THING HAPPENED. Which this let me know that the natural home remedies of fruits and vegetables and spice and herbs are working to keep me healthy.

Most people that use the Wildcrafted Jamiacan Duck Flower end up having worms in their fecal matter. I had not a darn thing happened and I was on a BigO live trying to show people what was going on so they know what to expect. Mine was a complete flop. However, I am glad it did that just means I need to lose weight.
I’m New here, and curious to what is community has to offer. Or more over’ what I have to offer this community.
Full on warning⚠️
I believe that I am pretty funny, but others may think that my jokes are crap.
You have been warned
I’m new here and I’m very excited to find this exceptional resource for everything microbiome! Thank you!
I’m interested in your thoughts about using young, healthy, well-matched donors for microbiota transfer treatments from the rest of the body (besides stool) including: oral (separate multi-kingdom communities including biofilms from the oral cavity), vaginal, nasal, skin, and so forth. I know that vaginal microbiota transplants have been used successfully for bacterial vaginosis, but I can foresee a future where everything from tears and menstrual blood to volatile organic compounds from the lungs and more being used to save lives! Everything previously thought as simply waste products being used instead to reboot an older and/or weaker body. Can you imagine how wonderful it would be to see healthy young people compensated for everything they would’ve ordinarily thrown away? Ideally one would find a few excellent “mini-me’s” that would be available for donations.
My other question is, looking for the best donor, why wouldn’t it be a good idea to find the best fit possible, for example, matching blood types, sex, and possibly key genetics such as the major histocompatibility genes? (In addition to the very best screening techniques for any pathogens.)
Also, although there may not be clinical trial results available yet for the perfect protocols, if one has major inflammation caused by a variety of pathogens, why wouldn’t we try eliminating the pathogens effectively first; such as using antibiotics, anti-fungals, anti-parasitics, antivirals and/or bacteriophages as needed, to eradicate the pathogens before the transplants?
I would love to hear what your thoughts are about these questions.
Michael Harrop
Michael Harrop
You commented on your own profile instead of making a new thread.

Most of your questions are also answered in existing threads.
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SFBayFMT5
I suspect that the microbiota most direly missing from my own intestinal tract are mostly facultative anaerobic small intestinal microbes (things like Actinomyces, Gemella, non-Copri strains of Prevotella, possibly Neisseria, etc.), NOT the kind of colonic anaerobes that are entirely focused on in nearly all studies of FMT (i.e. the clostridium clusters, Bacteroides, and purely fermentative actinobacteria like Bifidobacterium, Eggerthella, Collinsella, etc.). This is actually the single biggest methodological issue I have with the FMT studies to date.

These bacteria have much more in common with the oral microbiome than the fecal microbiome, hence I have a suspicion that oral microbiota capsules would work better than fecal ones. They would at least be much easier on the donor than trying to collect from the small intestine itself. You'd obviously need to do something to ensure good oral health, including the absence, or at least minimal presence, of proteolytic fermenters like Tannerella, Porphyromonas, Treponema etc., which I DON'T think you want to transmit. But using material sourced from higher up like this would eliminate the issue of large numbers of rectal bacteria being introduced into the upper GI tract and causing bloating, indigestion, "brain fog", and other similar symptoms that seem to be very common in oral FMT reports here and elsewhere.

If you're aware of anyone actually working to make this a reality, I'd be happy to hear about it and give it a try. I've been looking for something like this for a long time.
Hi i have couple of question if u dont mind answering i would really appreciate it:)



How does bile affect stool form? I ask because i have tyoe 1 and 2 no matter what, the only thing that helps are a lot of mg or other laxatives but im aware thats just a bandaid



Are there any known mechanism by which large intestine fmt can influence small intestinal microbiome?



I read posts about mucosal microbiome being a problem, how to aproach this issue in ur opinion?



How are obligate anaerobes preserved in fmt?
How does pricing work for untested donors (which I see some people have tried)? Do they charge less than fully activated donors, given the greater risk involved? Is it possible that if people agree to pay to have a donor tested, that then the cost of orders is reduced for them given their commitment to support the activation of the donor?
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Michael Harrop
Michael Harrop
Pricing is not related to whether a donor has gone through the blood & stool testing. That would encourage people to take more risks which is not a good idea.
Did you see my reply to your experience report on the forums? I'm particularly interested in your experiences with the currently active donors FL-RS-1997 and UT-AW-1998, in other words whether one of those two was significantly superior/inferior to the other.
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SFBayFMT5
@Fmt2024 are you zal63 under a different account? The experience report I was referring to was by zal63.
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Fmt2024
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SFBayFMT5
Not nosy as much as giving experiences that might not agree with what the person experienced who actually had my kind of profile and benefited from SD-ES-2015. Since SD-ES-2015 is untested, I wouldn't try her until she's been tested. I've already tried UT-AW-1998, so my real question is, for those for whom SD-ES-2015 is particularly good, does FL-RS-1997 even come as a remote second, or is he way behind the other two.
I saw your post about which criteria make a difference when choosing a donor. I wrote my own thoughts on that here--though like yours, they are based on theorizing/hypotheses and not on actual experience.

https://forum.humanmicrobiome.info/threads/the-evidence-and-rationale-supporting-our-stool-donor-criteria-2022-hu.131/post-834


Actual experience regarding these factors may be hard to come by, as most FMT providers don't provide ANY demographic information about donors at all--it's impossible to even tell if you got the same or a different donor as someone else who reported an experience with that same provider. That's the great thing about HMorg that sets them apart from other providers, donor characteristics and interview responses are available to recipients.

However, aside from Michael Harrop himself who has tried many donors, there aren't that many people who have tried enough to clearly be able to test hypotheses (and even if they have, such is difficult to tell from the results spreadsheet due to inconsistent recipient identifiers--an issue that I posted about on the forum before). That gets me to the other thing I wanted to point out, which really was the main purpose of this message--despite how it looks from the "orders" page of HMorg, there are ONLY two donors (one male, FL-RS-1997, and one female, UT-AW-1998) who are currently willing to provide stool AND are tested for pathogens. All the other "current" donors in the spreadsheet have not been tested, which explains why there are so many fewer experience reports for them--only brave souls who accept untested donors have tried those.

To be fair to HMorg, you will be freely informed of this fact if and when you decide to place an order--however it would be helpful to know this ahead of time, as it will likely give you a much better idea of the options you have to choose from. It certainly did for me. I have been told that two other potential donors, one of each sex, are in the process of being "activated" (the term HMorg uses to refer to the blood and stool pathogen testing), though I have no idea how long this will take. To see these you would need to request the longer donor list, which I won't link to as Michael Harrop doesn't want it shared publicly, which I respect. If you ask he will send it. I WILL say though that NEITHER of these is among the people in the spreadsheet who actually have experiences posted about them. It seems none of those will ever be tested unless some of us customers agree to come together and pay to have it done.
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Fmt2024
Oh I probably have the longer list then
F
Fmt2024
Do we know what the experiences were like with these donors?
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SFBayFMT5
@Fmt2024 there are no posted experience reports at all with either of the unactivated (i.e. untested) donors who are supposedly pending testing--neither in the spreadsheet nor on the forums. The stool/fitness pictures as well as the questionnaire results are in the longer list, as for the other donors, that is ALL we have.
Two quite specific questions about HMorg specifically (feel free to move to forum if there's a better place for it):
1) How does the shipping cost compare to the cost of capsules/stool? In other words, how many capsules worth of money can be saved for each extra shipment that is eliminated by combining it with another (provided all shipments are from the same donor, such that combining is even possible)?

2) Any information on diet of donors? I have a dairy allergy and if I recall correctly, OpenBiome donors eat a hypo-allergenic diet prior to donation. My allergy isn't life threatening or anything so it's not so much a safety issue, but still, exposure to dairy and foods I'm sensitive to causes flares--so first if there are two roughly equivalent donors but one eats large amounts of foods I'm sensitive to, it might be wise to avoid that donor, and secondly, even if exposure is unavoidable it's good to know so that I can better separate food reactions (which are likely to be short term) from microbiome effects (which are likely to be more persistent).
Hi Michael Harrop !! I m Lindi De Medeiros l m New Member here and l m really Happy To be a part of the Team in the future !!
I Hope everything is going well to l start with Human Microbiome this Amazing opportunity to Help the science and peoples!!
R
RobertCAlexander
Greetings Lindi. Im Robert and Im new to the forum and this opportunity as well. I never imagined there was such a deep study involving FMT. I just spent over a week reading all the fascinating links that Dr. Harrop has provided.
Hello there dear fellows at Human Microbes Forum , i'm a new member here my name is Jhen Rivera i'm looking forward sharing as well as to exchange ideas to get our stool community supported and have Mr Michael Harrop headed to lead this way , in that order of ideas , i'm bringing in on my co-working fellows partners municipal structure command coordenates members that cognitivelywise are with me .
Michael, hi! I have some viable information and experience with donors and administering FMT’s. My husband and I traveled to Australia to meet with Prof. Borody, he taught me everything I needed to know and together we cured my husband of his ulcerative colitis. The donor does not have to be super, perhaps more FMT’s are required to achieve the end result. It works, like manure works to fertilize!
Michael Harrop
Michael Harrop
Yes, that is covered in the wiki https://humanmicrobiome.info/fmt/#procedure. It's true that people can benefit from low-quality donors, but it's a matter of risk vs reward, and percentages. How many other people would benefit from that donor? How many would be harmed? That is what I try to figure out. Even with seemingly-great donors, people can still be harmed.
I have a post on here about a clinic in the US that does FMT for patients without recurrent cdiff infections. I've only had cdiff once, so am not a candidate at other places I've looked into.
What phage supplement do you take? I'm looking at adding them to my regiment after reading several articles linked on this site.
Hello my name is Travis still feel the same about my symptoms I've been doing everything and I have a doctor appointment on November the 10th to see I don't know the procedure but they call it the pill I take for my colon to see what's wrong with my stomach and I will let you know what happened from there
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