Probiotic may improve sleep quality (Dec 2024, n=60) Regulation of Sleep and Circadian Rhythms by S-Adenosylmethionine-Producing Probiotics Probiotics 

Michael Harrop

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https://www.eurekalert.org/news-releases/1078283
https://www.sciencedirect.com/science/article/pii/S2095809924007422

a team of scientists from Jiangnan University and other institutions, focuses on the role of S-adenosylmethionine (SAM)-producing probiotics in regulating sleep and circadian rhythms.

the researchers first conducted a cross-sectional analysis and found that serum SAM levels were significantly reduced in insomnia patients

The team then screened 60 gut strains and identified Lactobacillus helveticus CCFM1320, a high-SAM-producing probiotic

The researchers conducted a four-week placebo-controlled clinical trial involving 60 volunteers with insomnia. The results showed that CCFM1320 significantly improved sleep quality in patients with sleep disorders

Although the overall gut microbiota diversity did not change, the intervention affected the composition and abundance of core microbiota species. Probiotic treatment reduced the number of potentially pathogenic species and increased the abundance of some beneficial bacteria

Abstract​

Current first-line medications for sleep disorders often overlap with antidepressants, yet their effectiveness remains suboptimal, highlighting the urgent need for novel therapeutic strategies based on new mechanisms.

Our study initially identified a significant reduction in serum S-adenosylmethionine (SAM) levels in insomnia patients through a cross-sectional analysis, suggesting SAM as a potential biomarker and therapeutic target for sleep disorders.

We then screened 60 gut strains across seven species and identified a high-SAM-producing probiotic, Lactobacillus helveticus CCFM1320, which improved cognitive and memory impairments caused by sleep deprivation in mice. Mechanistically, CCFM1320 enhances the methylation of N-acetylserotonin, a precursor of melatonin synthesis, normalizing the expression of downstream circadian rhythm genes.

A subsequent four-week placebo-controlled clinical trial demonstrated that CCFM1320 significantly improved sleep quality in patients with sleep disorders, as evidenced by reduced Pittsburgh sleep quality index (PSQI) scores, lower serum cortisol levels, and decreased prevalence of pathogenic species in the gut. Probiotic treatment also elevated the abundance of SAM synthesis and metabolism-related enzyme genes in the gut microbiome, likely due to the introduction of high-SAM-producing probiotics and subsequent SAM accumulation.

This study presents a promising probiotic-based strategy for managing sleep disorders, offering a potential non-pharmacological treatment alternative.
 
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