fmt failure

  1. Michael Harrop

    FMT The effect of fecal microbiota transplantation on quality of life in patients with chronic pouchitis: a post hoc analysis of the MicroPouch trial (May 2026) FMT-treated patients showed a significant decrease in QoL from baseline.

    https://journals.sagepub.com/doi/10.1177/17562848261452497 A group from Denmark. Ridiculous donor criteria. The fact that they passed 13 of them highlights that. It should be no surprise that they made patients worse. Yet they didn't even try.
  2. Michael Harrop

    FMT Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial (Aug 2025, n=20) "FMT did not significantly affect hepatic steatosis, glucose tolerance, liver biochemistry, or gut microbiota signatures"

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2541035#abstract Donors: More evidence that the stool bank model and the standard donor criteria are non-viable. Zero results for "symptoms" or "adverse events". So it doesn't appear that they were tracked at all. It's incredible...
  3. Michael Harrop

    FMT Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability (Jul 2025, n=12, enema over 6 mo, Biomebank) No significant motor symptom changes. No sustained improvement in non-motor symptoms.

    https://www.nature.com/articles/s41531-025-01061-5 Australian group that used the TGA-approved, GMP stool bank. More evidence that GMP stool banks are not valid approaches to FMT.
  4. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx https://www.gutmicrobiotaforhealth.com/fecal-microbiota-transplantation-unable-to-induce-remission-at-8-weeks-in-adults-with-crohns-disease/ A slightly different version was published...
  5. Michael Harrop

    FMT Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn’s disease: a prospective trial (Mar 2025, n=49) "remission rates did not differ between the two groups"

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05832-1
  6. Michael Harrop

    FMT Faecal microbiota transplantation in patients with systemic sclerosis and lower gastrointestinal tract symptoms in Norway (ReSScue): a phase 2, randomised, double-blind, placebo-controlled trial (Jan 2025, n=67) "no improvement in lower GI symptoms; one duodenal perforation instance"

    https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00334-5/abstract Here we have a real-life example of the risks that come with standard medical procedures. It's one of the reasons FMT is more risky when done like this, via colonoscopy, etc. I can't look at their donor quality...
  7. Michael Harrop

    FMT Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled trial (Dec 2024) "no difference vs placebo except for constipation, depression, and anxiety symptoms"

    https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03781-6 15 out of 213. Terrible pass rate. Low-quality donors. So lower-route only. My takeaway is that "constipation, depression, and anxiety" are easier to treat, at least via lower-route.
  8. Michael Harrop

    FMT Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s disease (Nov 2024, n=34) "FMT was not effective "

    Study https://journals.lww.com/ajg/abstract/9900/preliminary_results_from_a_multicenter,_randomized.1438.aspx Article https://www.healio.com/news/gastroenterology/20250619/fecal-microbiota-transplantation-unable-to-induce-remission-in-crohns-disease Appears to be standard poor donor quality...
  9. Michael Harrop

    FMT Microbiota Transplantation in Individuals with Type 2 Diabetes and a High Degree of Insulin Resistance (Oct 2024, n=21) "neither FMT from healthy and lean donors nor a probiotic were effective"

    https://www.mdpi.com/2072-6643/16/20/3491 Another failed FMT trial. Ridiculous criteria. What a joke. Completely incompetent research system. Huge waste of time and money.
  10. Michael Harrop

    FMT Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility (May 2024, n=72)

    https://www.cghjournal.org/article/S1542-3565(24)00492-0/fulltext A group from Belgium. Their donors: This is the second trial that I recall that tried to select donors this way and failed. The previous one: Fecal Microbiota Transplantation engraftment after budesonide or placebo in...
  11. Michael Harrop

    FMT VA trial using the University of Minnesota's donors, finds no reduction in C diff recurrence after FMT (Sep 2024, n=153, UMN) A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection

    Article: VA trial finds no reduction in C diff recurrence after fecal microbiota therapy https://www.cidrap.umn.edu/antimicrobial-stewardship/va-trial-finds-no-reduction-c-diff-recurrence-after-fecal-microbiota Commentary: Déjà vu: Unanswered Questions about Fecal Microbiota Transplantation for...
  12. Michael Harrop

    FMT Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients (Aug 2024, n=49)

    https://www.nature.com/articles/s41522-024-00549-x They essentially took a low-quality donor, measured that the donors microbes colonized the recipient, but didn't improve symptoms. This shouldn't be surprising. Hilarious. They're using El-Salhy's criteria to define super-donor. 0 results...
  13. Michael Harrop

    FMT Effects of Fecal Microbiome Transfer in Adolescents With Obesity. The Gut Bugs Randomized Controlled Trial (Dec 2020, n=87) "FMT alone did not lead to weight loss at 6 weeks."

    Reposting this to add newer links from this study/group. Original posts in 2020 and 2021. Articles: https://www.medpagetoday.com/pediatrics/obesity/90350...
Back
Top Bottom