fmt failure

  1. Michael Harrop

    FMT Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s disease (Nov 2024, n=34) "FMT was not effective "

    https://journals.lww.com/ajg/abstract/9900/preliminary_results_from_a_multicenter,_randomized.1438.aspx Appears to be standard poor donor quality criteria.
  2. Michael Harrop

    FMT Microbiota Transplantation in Individuals with Type 2 Diabetes and a High Degree of Insulin Resistance (Oct 2024, n=21) "neither FMT from healthy and lean donors nor a probiotic were effective"

    https://www.mdpi.com/2072-6643/16/20/3491 Another failed FMT trial. Ridiculous criteria. What a joke. Completely incompetent research system. Huge waste of time and money.
  3. Michael Harrop

    FMT Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility (May 2024, n=72)

    https://www.cghjournal.org/article/S1542-3565(24)00492-0/fulltext A group from Belgium. Their donors: This is the second trial that I recall that tried to select donors this way and failed. The previous one: Fecal Microbiota Transplantation engraftment after budesonide or placebo in...
  4. Michael Harrop

    FMT VA trial using the University of Minnesota's donors, finds no reduction in C diff recurrence after FMT (Sep 2024, n=153, UMN) A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection

    Article: VA trial finds no reduction in C diff recurrence after fecal microbiota therapy https://www.cidrap.umn.edu/antimicrobial-stewardship/va-trial-finds-no-reduction-c-diff-recurrence-after-fecal-microbiota Commentary: Déjà vu: Unanswered Questions about Fecal Microbiota Transplantation for...
  5. Michael Harrop

    FMT Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients (Aug 2024, n=49)

    https://www.nature.com/articles/s41522-024-00549-x They essentially took a low-quality donor, measured that the donors microbes colonized the recipient, but didn't improve symptoms. This shouldn't be surprising. Hilarious. They're using El-Salhy's criteria to define super-donor. 0 results...
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