engraftment

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    Outcomes Why do some people have permanent effects and others don’t? Donor quality vs matching.

    So, after having seen outcomes here and on the HM spreadsheet, I still am unable to see a clear pattern that can explain why some people take FMT better and others don’t. Some, like @Michael Harrop, believe its a combination from donor quality and colonization resistance from recipients (which...
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    FMT A simulation of 2,548 gut transplants identified two “super donors” with near-universal colonization success (Sep 2026, multiple models) Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies

    https://www.tandfonline.com/doi/full/10.1080/19490976.2026.2725403 https://biomesci.com/gut-microbiome-super-donor-fmt-metabolic-model/ Many things here about donor quality and matching that @Michael Harrop already has hypothesized and attested to anecdotally. But to me the biggest takeaway...
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    FMT Only 4.7% of apparent FMT colonization events involve actual donor strain replacement (Aug 2026, n=13) Strain-level ecological filtering governs microbial colonization of the human gut

    https://biomesci.com/fmt-strain-level-colonization-cell-reports/ https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00853-3
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