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  1. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx The usual poor donor criteria. Sometimes low-quality donors turn out worse than other times.
  2. Michael Harrop

    Causation Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis (Mar 2025)

    https://www.psypost.org/gut-bacteria-may-play-a-causal-role-in-obsessive-compulsive-disorder-study-suggests/ https://www.sciencedirect.com/science/article/abs/pii/S0165032725003167
  3. Michael Harrop

    Aging Causal Analysis Between Gut Microbes, Aging Indicator, and Age-Related Disease, Involving the Discovery and Validation of Biomarkers (Apr 2025) "Gut microbiota a potential risk factor for 14 age-related diseases. Exhibit biomarker properties for disease prediction"

    https://www.fightaging.org/archives/2025/06/evidence-of-causation-in-human-data-on-the-gut-microbiome-and-age-related-conditions/ https://onlinelibrary.wiley.com/doi/10.1111/acel.70057
  4. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2508950 UMN GMP stool bank provides insights from their and other companies' experiences. UMN appears to have some of the worst donors that exist anywhere. Interestingly, they mention relevant info about the donor recruitment, payment...
  5. Michael Harrop

    Other H. Pylori bacteria that causes stomach ulcers may protect the brain from Alzheimer’s and Parkinson’s (Jun 2025) Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

    https://theconversation.com/alzheimers-bacteria-that-cause-stomach-ulcers-may-protect-the-brain-our-new-research-indicates-259018 https://www.science.org/doi/10.1126/sciadv.ads7525
  6. Michael Harrop

    FMT Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection: A Randomized Controlled Trial (Jun 2025, n=104) "Clinical cure with no recurrence seen in 67% for FMT vs 61% for vancomycin. Up to 78% for FMT with additional treatment"

    https://www.acpjournals.org/doi/10.7326/ANNALS-24-03285 This is a unique study because usually FMT is only given after antibiotics fail.
  7. Michael Harrop

    Article Dwayne 'The Rock' Johnson reveals surprising health battle and how he fought back (Jun 2025) "digestive issues linked to prior courses of antibiotics"

    https://archive.ph/MoK5H https://www.thenews.com.pk/latest/1321180-dwayne-johnson-reveals-shocking-battle-with-years-of-health-problems Interesting article with some important info and some pseudoscience. The first part is alarmingly common, and a major root cause of the chronic disease...
  8. Michael Harrop

    FMT The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study (Jun 2025, n=172). Partial remission 55%, complete remission 32% for resistance training group, and 67% partial, 45% complete for FMT+resistance group

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06557-5
  9. Michael Harrop

    FMT Fulminant Clostridioides difficile Infection Following Fecal Microbiota Spores Compared to Fecal Microbiota Transplant (May 2025, n=130) Patients receiving VOUST's fecal microbiota spores live-brpk were more likely to develop severe disease, called fulminant C. diff infection

    https://www.newswise.com/articles/new-treatment-for-c-diff-infection-may-be-less-effective-than-traditional-therapy-study-finds/ https://www.cghjournal.org/article/S1542-3565(25)00420-3/abstract Closed access.
  10. Michael Harrop

    FMT Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results (Jun 2025, n=4) "FMT through colonoscopy showed improvement in pain, bloating, and stool consistency that was maintained during the 6-month follow-up"

    https://www.sciencedirect.com/science/article/pii/S2255534X25000647
  11. Michael Harrop

    Probiotics Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial (Jun 2025, n=190) "incidence of POCD in the probiotic group was significantly lower than in the control group"

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06584-2
  12. Michael Harrop

    Causation Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study (Jun 2025)

    https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-025-03789-x
  13. Michael Harrop

    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    https://www.dw.com/en/fecal-transplants-study-is-a-wake-up-call-for-the-field/a-72817699 https://www.the-independent.com/news/health/fecal-transplants-consequences-research-us-b2765279.html...
  14. Michael Harrop

    FMT Public knowledge, awareness and perception of gut microbiome and faecal microbiota transplantation in Singapore: a survey study (Jun 2025, n=1831) "33% had heard of the gut microbiome, 92% had consumed probiotics, 85% had not heard of FMT, 72% would consider FMT to treat C. diff"

    https://journals.lww.com/smj/fulltext/9900/public_knowledge,_awareness_and_perception_of_gut.196.aspx
  15. Michael Harrop

    Antibiotics Human antibiotics are polluting Earth's rivers, helping bacteria develop the resistance they need to then kill humans (Apr 2025) Antibiotics in the global river system arising from human consumption

    https://www.earth.com/news/earth-rivers-are-highly-saturated-with-human-antibiotics-helping-bacteria-develop-resistance/ https://academic.oup.com/pnasnexus/article/4/4/pgaf096/8113371
  16. Michael Harrop

    Oral Causal association between oral microbiota and oral cancer: a mendelian randomization study (Jun 2025) "Our findings suggest that Prevotella and Veillonella were causally linked to OC"

    https://www.nature.com/articles/s41598-025-05553-5
  17. Michael Harrop

    FMT Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice (Jun 2025) "human-derived microbiota was less effective in clearing C. difficile compared to a mouse-derived microbiota"

    https://journals.asm.org/doi/10.1128/mbio.01108-25
  18. Michael Harrop

    FMT Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis (Jun 2025, n=27) "the effect depends on the specific donor microbiota and not on patient fiber use"

    https://www.cell.com/med/abstract/S2666-6340(25)00134-5
  19. Michael Harrop

    FMT Donor-derived microbial engraftment and gut microbiota shifts associated with weight loss following fecal microbiota transplantation (Jun 2025, n=23) "52% achieved weight loss of more than 5% from baseline. Average weight loss of 8kg/18lbs"

    https://journals.asm.org/doi/10.1128/aem.00120-25 Chinese study. 52% achieved weight loss of more than 5% from baseline. Average weight loss of 8kg (18 lbs). Nonresponders lost 3kg. Contrary to some other studies, they found engraftment to correlate with success. Donors: But they couldn't...
  20. Michael Harrop

    Fungi Gut fungi in very-low-birthweight infants modulate oxygen-induced lung damage (Jan 2025) The fungal microbiota modulate neonatal oxygen-induced lung injury

    https://www.eurekalert.org/news-releases/1086041 https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-025-02032-x
  21. Michael Harrop

    Origins The human milk microbiome is minimally associated with breastfeeding practices (Jun 2025, n=56)

    https://www.nature.com/articles/s41598-025-03907-7
  22. Michael Harrop

    FMT Fecal microbiota transplant is associated with resolution of recurrent urinary tract infection (May 2025) "Of 11 patients who had rUTI in the two years preceding FMT, no patient had rUTI over the 2-year follow-up period after FMT"

    https://www.goldjournal.net/article/S0090-4295(25)00515-1/fulltext
  23. Michael Harrop

    Early development Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment (May 2025, mice) "finding suggests that the host early in life has mechanisms to select microbes appropriate for age"

    https://www.nature.com/articles/s41598-025-03661-w Given that dysbiosis generally increases with age, to me, it sounds more like the mucosa gets worse at resisting problematic microbes as age increases.
  24. Michael Harrop

    Oral Swapping spit with your spouse may spread anxiety and depression (Apr 2025, 536 couples) Oral Microbiota Transmission Partially Mediates Depression and Anxiety in Newlywed Couples

    https://newatlas.com/mental-health/oral-microbiome-spouse-anxiety-and-depression/ https://www.xiahepublishing.com/2472-0712/ERHM-2025-00013
  25. Michael Harrop

    FMT Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis (May 2025) "neuroinflammation occurred independently of gut barrier disruption, implicating circulating microbial metabolites"

    https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1593854/full
  26. Michael Harrop

    FMT Therapeutic efficacy of fecal microbiota transplantation in severe food intolerance: a case report (May 2025, 7-year-old autistic child)

    https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1594022/full They have pictures of the patient's stool as it progresses https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1594022/full#F1. This is the first time I can recall seeing that. I...
  27. Michael Harrop

    FMT Investigating fecal microbiota transplants from individuals with anorexia nervosa in antibiotic-treated mice using a cross-over study design (May 2025) "AN-GM may contribute to altered food intake and appetite regulation, which can be ameliorated with FMT from a non-eating disordered donor"

    https://jeatdisord.biomedcentral.com/articles/10.1186/s40337-025-01276-0
  28. Michael Harrop

    FMT Fecal microbiota transplantation alleviates immunosuppressant-associated diarrhea and recurrent urinary tract infection in kidney transplant recipients: a retrospective analysis (May 2025, n=18)

    https://gutpathogens.biomedcentral.com/articles/10.1186/s13099-025-00705-4
  29. Michael Harrop

    Other Almost all babies who contract HPV perinatally eliminate it within the first six months of life (May 2025, n=422) Human Papillomavirus Persistence, Recurrence, and Incidence in Early Childhood

    https://nouvelles.umontreal.ca/en/article/2025/05/14/hpv-babies-free-themselves-of-the-virus-naturally/ https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaf213/8129394
  30. Michael Harrop

    Antibiotics Metabolic and immune consequences of antibiotic related microbiome alterations during first-line tuberculosis treatment in Bamako, Mali (May 2025, n=30) "Numerous changes in bacterial taxa abundances and inflammation-linked metabolites did not reverse at Month-15"

    https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1561459/full
  31. Michael Harrop

    Other Potent molecule targets chlamydia bacteria while sparing beneficial microbes (Apr 2025) A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia

    https://phys.org/news/2025-05-potent-molecule-chlamydia-bacteria-beneficial.html https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003123 I look forward to the day when I can have sex with everyone I meet without worrying about STIs.
  32. Michael Harrop

    Other Early-Life Exposure to Certain Bacteria May Contribute to the Rising Incidence of Impact Early-Onset Colorectal Cancer (Apr 2025) Geographic and age variations in mutational processes in colorectal cancer

    https://www.infectiousdiseaseadvisor.com/news/early-life-exposure-to-certain-bacteria-may-impact-early-onset-colorectal-cancer-incidence/ https://www.nature.com/articles/s41586-025-09025-8
  33. Michael Harrop

    Article Your gut microbes might encourage criminal behavior. Is “My microbes made me do it” a valid legal defense? (May 2025)

    https://www.technologyreview.com/2025/05/09/1116211/gut-microbes-criminal-behavior/ I certainly agree. Which is one reason I think society will be quite utopian once we fix our biological defects.
  34. Michael Harrop

    Other Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome (May 2025, mice) "The results suggest that targeting the gut microbiota may offer a strategy for preventing preeclampsia"

    https://www.nature.com/articles/s41467-025-58533-8
  35. Michael Harrop

    Antibiotics Prolonged effect of antibiotic therapy on the gut microbiota composition, functionality, and antibiotic resistance genes’ profiles in healthy stool donors (May 2025)

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1589704/full A really interesting and well-done study of all the different ways antibiotics negatively impact the gut microbiome, beyond basic measurements like diversity and composition. The report also reveals the...
  36. Michael Harrop

    FMT Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis (May 2025, n=96) FMT from humans to mice confirmed the cognitive benefits were microbiota-dependent

    https://gut.bmj.com/content/early/2025/05/07/gutjnl-2025-335353
  37. Michael Harrop

    Causation Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study (Feb 2025)

    https://medicalxpress.com/news/2025-05-twin-bacteria-small-intestine-play.html https://www.pnas.org/doi/10.1073/pnas.2419689122
  38. Michael Harrop

    Causation Certain bacteria in breast tumour environments may fuel cancer spread (Feb 2025, mice) Identification of intratumoral bacteria that enhance breast tumor metastasis

    https://www.med.ubc.ca/news/certain-bacteria-in-breast-tumour-environments-may-fuel-cancer-spread/ https://journals.asm.org/doi/full/10.1128/mbio.03595-24
  39. Michael Harrop

    Probiotics Developing a probiotic cocktail that may help ward off dementia (Jan 2025) Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail. "Underlying mechanisms may differ depending on sex"

    https://medicalxpress.com/news/2025-05-probiotic-cocktail-ward-dementia.html https://www.nature.com/articles/s41598-024-84780-8
  40. Michael Harrop

    Early development In utero human intestine contains maternally derived bacterial metabolites (May 2025, n=21)

    https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-025-02110-0 It wasn't clear to me how they checked metabolites from the in utero human intestine. If someone can explain that, it would be helpful.
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