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  1. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I haven't been on this forum for a long time. See below some questions. 1: What are the odds that it will turn out that the gut biota are not as impactful as many thought? To what extent is there unwarranted "hype" around gut biota? See here, for example...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I wouldn't be surprised if addressing gut-biota problems fixed any psychiatric condition. Of course, a big question is whether there will be any clinical trials that will take a gut-biota treatment (in this case, for bipolar) from anecdote to something more than anecdote. Do you know any trials...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Doesn't seem like it's possible to buy an L-DOPA supplement. You can only get the one that isn't "earmarked" for production of DA and NE, right?
  4. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: I took some 5-HTP last night and it made a huge (!!!) difference. I really hope that this quite miraculous improvement doesn't go away. 2: When was the last time you took some 5-HTP? Baffling to me why it stopped working for you; hope you can get the effect back. 3: What can one say about...
  5. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Do you guys know a lot about butyrate and butyrate supplementation? See this excellent paper: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.893567/full. The paper says interesting things about butyrate, including the following: 2: I took some butyrate pills...
  6. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: I get a huge reaction from melatonin. That's why I'm interested in agomelatine, which apparently has a superior melatonin-receptor effect to melatonin's, though I can't remember what exactly the advantage is supposed to be. 2: Melatonin is a fascinating thing...see this paper here...
  7. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks for the excellent points. I appreciate it. 1: If you don't mind me asking, what are your credentials? You seem to have professional knowledge. 2: What do you think about Pendulum's products? Some of their products seem to be redundant. I think that the "Metabolic Daily" one contains...
  8. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you guys think about the cocktail that is mentioned below? And is that cocktail at all close to being available to consumers? https://www.mdpi.com/2076-2607/12/8/1627
  9. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks. I assume that only trial and error can tell you which of the below is the best value for the money? They're all different prices on a per-capsule basis. https://www.amazon.ca/Boulardii-Billion-Diarrhea-Relief-Capsules/dp/B00CORN7PW...
  10. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Regarding treatment of dysbiosis, what are the implications of the bold part below? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300896/ How often do people use this type of probiotic? I hadn't heard of it...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I sometimes have these insane (absolutely INSANE) "collapses". I wonder whether phages might cause these collapses ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764184/ ). 1: Phages might be responsible for a lot of people's dysbiosis, right? 2: But aren't people kind of screwed in the...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Is there any science (or speculation) that might explain the below scenario? --someone is taking a couple basic probiotics (Align and Culturelle) and doing extremely well thanks to those probiotics --the person suddenly undergoes a "collapse" where they lose all the wonderful health...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: What do you guys think about this? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389721/ 2: And this? 3: If a given probiotic only benefits you by creating a certain SCFA, is just supplementing that SCFA (by taking a "postbiotic") a superior option?
  14. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Anyone here heard of combining apple-cider vinegar with probiotics? Not sure if there's any experience showing that that combo can be useful. Or any science that would point toward a potential synergy there. 2: What explains the seemingly weird precariousness regarding the fact that a human...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I wonder about this: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.993451/full Some probiotics are mentioned below that I haven't heard much about. I'd love to try some of these less-known probiotics eventually if the better-known ones aren't sufficient...
  16. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I posted the below: I got this response so far: I wonder what limitations the studies linked above (by the PhD guy) have. And to what extent can those studies' conclusions really be generalized? People are different, right? I really hope that I can change my gut-biota situation. Otherwise...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: My curiosity about "muddying the waters" was that if you resist the temptation to add another probiotic to the ones you''re taking then you'll get better information than if you rush ahead. Do you see the conundrum? Adding new probiotics might improve things but also "muddies the waters" in...
  18. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: If there's a microbe that "eats" quercetin and you pump quercetin in your body, that's a great thing. But do you know any actual papers on the notion that pumping nutrients into your gut will end up expanding the population of whichever microbes eat that nutrient? Maybe there aren't any...
  19. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Have you tried this and is it worth trying? https://seed.com/daily-synbiotic 1: Have you tried a VERY high dose of bromelain? And of quercetin? And of both of the two? 2: Why did the below work so well for you but then stop working? I don't get it. Have you asked scientists why something...
  20. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Just to reiterate something we talked about previously, we can't possibly know how much impact on the human brain and body the loss of various bacterial strains has had, correct? 2: What is the "ceiling" in terms of the maximum impact that the loss of a single strain could have on the human...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Doesn't the below information provide some very clear ideas about what to try? And yet doctors won't be able to recommend ideas to patients on the basis of the below information, right? Large-scale clinical trials are needed before doctors can recommend things, correct...
  22. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I just tried this today for the first time and so far it's been a smashing success: https://en.wikipedia.org/wiki/Quercetin. I want to try bromelain too. Do you know about bromelain and quercetin? Have you tried them yourself?
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I apologize if I asked this previously, but why can't SCFAs just be supplemented directly? Why can't one just take pills that contain SCFAs? I know that that might not be as healthy as producing SCFAs the natural way in your colon, but nevertheless I wonder about whether direct supplementation...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I just wanted to know if you'd find anything interesting in those papers. Have you tried pectin? What are your favorite prebiotics? I found this interesting: https://www.sciencedirect.com/science/article/pii/S0268005X22004787
  25. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you make of this paper? https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.578386/full Hosting millions of microorganisms, the digestive tract is the primary and most important part of bacterial colonization. On one side, in cases of opportunistic invasion...
  26. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Where was the info on disruption, sorry? My apologies about not reading information; my mental health is often really bad. 2: Was your previous point just that the gastric and intestinal microbiomes are connected? They're still talked about as distinct things in the literature, right? 3: H...
  27. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks. I took a probiotic pill a couple days in a row. When I took the probiotic yesterday, it messed me up quite a bit. Is it normal for probiotics to make things worse at first? I can imagine that introducing new microbiota to your GI system could be disruptive.
  28. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What information/papers do you know of regarding the connection between gastric microbiota and intestinal microbiota? I thought they were separate. See here a paper that I just found randomly: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006573 Drivers of...
  29. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Do you know any papers on gastric dysbiosis? And on how important gastric dysbiosis can be? 2: Do you know any information (or papers) on how one can find out if one has gastric dysbiosis? And on what treatments are possible? I know that this is a somewhat random (maybe?) question, but do...
  30. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Have you tried everything that I mentioned in combination? I wonder whether doing so can make all the difference; if you try things individually then the effect might not be significant at all.
  31. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Michael, what's been your response to this combination: --lots of apple-cider vinegar (this is the main agent) --Pepto Bismol (a little bit) --NAC (the supplement, I mean...it has impacts on microbiota...it has impacts on various things) --the following cocktail of extracts: ginger...
  32. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I had an extremely good response to this: https://www.jamiesonvitamins.com/products/probiotic-ultra-strength-60-billion Lactobacillus paracasei (HA-196) 21.6 CFU Lactobacillus paracasei (R0215) 21.3 CFU Bifidobacterium breve (HA-129) 8.7 CFU Lactobacillus plantarum (R1012) 4.2 CFU...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you think of this? https://www.annualreviews.org/content/journals/10.1146/annurev-med-042320-014032 The effects of enteric microbial manipulations in controlled clinical trials in patients with depression and/or IBS have been evaluated with probiotics, antibiotics, and the low-FODMAP...
  34. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    It really freaks me out how I can't find a single (!!!) mention in the literature of a patient who goes through extreme flux of the sort that I live with. It's just downright weird how I took some psyllium husk and then my entire consciousness changed; that's weird. You'd think that there'd be...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    This seems like a really good review: https://www.annualreviews.org/content/journals/10.1146/annurev-med-042320-014032. Why do I get the sense that my problems are "bottom-up"? It's interesting how I have that sense. The review says that there's "top-down" causation too; not sure why I have...
  36. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I took some psyllium husk and it had a profound effect on my mind. Just like (sometimes) apple-cider vinegar has had a profound effect on my mind. It's not normal for things to go into your GI system and then have a profound impact on your brain. Do I have SIBO? Do I have something going on...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Have you ever gotten your blood's "inflammatory profile" checked? I'm curious because it seems like one could get some genuinely valuable data from looking at one's cytokine levels. I understand that it might be expensive and that it wouldn't magically tell you exactly what's wrong with you...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Should one actually be concerned about stomach microbes if H. pylori has been ruled out? I mean, see below a paper from 2015...not the newest paper...it talks about stomach microbes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616220/ Thick mucus layer, acidic gastric juice and peristaltic...
  39. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I have this really weird symptom; see below my description. Do you know how I could somehow get to the bottom of what this is? Just today my stomach (or something close to it) was "pulsing" a couple times and the "crackling" sensation seemed to go along with those pulsations. There seems to be...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Hey Michael; I've been gone a long time...have you made any important progress regarding your own health issues? My situation is weird. I'm going to do bloodwork regarding folate deficiency and B12 deficiency. I've had brief periods when taking those two nutrients where my brain and body were...
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