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  1. Michael Harrop

    Article The Poop Broker. Michael Harrop started a booming underground market for human feces. But something smells off about his product. (May 2024)

    Yeah it was an odd article. There were so many other interesting things that could have been covered. For example, the journalist noticed a trend of most recipients ordering FMT due to being harmed by antibiotics. I mentioned to the journalist that there are lots of laypeople who exhibit hostile...
  2. Michael Harrop

    Antibiotics Commonly used antibiotic brings more complications, death in the sickest patients (May 2024, n=7569) Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime

    Flagyl/Metronidazole was quite harmful for me as well.
  3. Michael Harrop

    Article The Poop Broker. Michael Harrop started a booming underground market for human feces. But something smells off about his product. (May 2024)

    I was thinking about this in the context of the media always complaining that they're dying and can't afford to fund themselves. For the past two days there have been dozens of articles in my news feed covering the same trivial story about one person doing DIY FMT from their boyfriend. Somehow...
  4. Michael Harrop

    Article The Poop Broker. Michael Harrop started a booming underground market for human feces. But something smells off about his product. (May 2024)

    https://slate.com/life/2024/05/fecal-transplant-fmt-c-diff-microbiome-poop-black-market.html Kind of an odd article. Amusing, seemingly agenda-driven, occasionally deceptive, but not all bad. I'm curious what impact this article will have. Will it be better or worse than the "complete silence"...
  5. Michael Harrop

    Study A long-term ketogenic diet accumulates aged cells in normal tissues (May 2024, mice) Ketogenic diet induces p53-dependent cellular senescence in multiple organs

    https://medicalxpress.com/news/2024-05-term-ketogenic-diet-accumulates-aged.html https://www.science.org/doi/10.1126/sciadv.ado1463
  6. Michael Harrop

    Article UK governments announce ban on wet wipes containing plastic (Apr 2024) "Wet wipes containing plastic are polluting our waterways and causing microplastics to enter the environment". 95% of respondents agreed or strongly agreed.

    https://www.circularonline.co.uk/news/uk-governments-announce-ban-on-wet-wipes-containing-plastic/ Nice to see the public and government supportive and taking steps to reduce plastic waste. Petition your own government to do the same!
  7. Michael Harrop

    Microbioma Microbioma.org full history and review

    It appears that the Microbioma guys successfully abused Reddit's automated systems to get the /r/Microbioma subreddit erroneously banned for spam https://web.archive.org/web/20240518081007/https://old.reddit.com/r/Microbioma/. They may be successful in getting Reddit to hand the sub over to them...
  8. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    The OP covered a unique method that one study used for diabetes patients. The next comment covers the possibility of using NAC. A colon cleanse doesn't seem sufficient https://humanmicrobiome.info/fmt/#before-the-procedure.
  9. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Related threads: Improve FMT effectiveness with mucus and biofilm dissolver? N-acetyl cysteine (NAC) FMT engraftment Strategies To Increase The Effectiveness Of FMT
  10. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    I posted about this a few years ago elsewhere and I'm copying all the info here for easy discussion. "While fecal microbiota is partially normalized by extended co-housing, mucosal communities associated with the proximal colon and terminal ileum remain stable and distinct". Comparison of...
  11. Michael Harrop

    Improve FMT effectiveness with mucus and biofilm dissolver? N-acetyl cysteine (NAC)

    I remember reading something on this topic but my memory is terrible right now and I can't remember exactly what it was. But this seems like something that should be tested in animal models first. I covered the possibility of a "mucosal microbiota transplant" in my FMT roadmap proposal. I...
  12. Michael Harrop

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    There appears to be an impact on lifespan, but not that much research on it yet https://humanmicrobiome.info/aging/. Most of the research looks focused on healthspan.
  13. Michael Harrop

    Antibiotics Commonly used antibiotic brings more complications, death in the sickest patients (May 2024, n=7569) Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime

    https://www.eurekalert.org/news-releases/1044459 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2818278
  14. Michael Harrop

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    https://www.aginganddisease.org/EN/10.14336/AD.2024.0321
  15. Michael Harrop

    Doxycycline Advice

    https://humanmicrobiome.info/faq/ https://humanmicrobiome.info/probiotic-guide/ In my opinion (+ https://humanmicrobiome.info/antibiotics/), nothing but FMT will reverse that damage.
  16. Michael Harrop

    Capsules from HMorg--what type? Delayed release, enteric coated.

    Delayed release is generally similar to enteric coated, but some types of material that capsules can be made from are acid-resistant and delayed release without requiring an enteric coating. Some of the enteric coating ingredients are possibly not the most healthy. I've tried delayed...
  17. Michael Harrop

    Vaccines Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? (May 2024, NYT) All vaccines have at least occasional side effects. But people who say they were injured by Covid vaccines believe their cases have been ignored.

    Were either of you vaccinated? Either way, FMT is likely the solution: The gut microbiome, COVID-19, and long COVID [collection of studies] https://humanmicrobiome.info/brain/
  18. Michael Harrop

    Is that IBS? Is that SIBO? Is that SIFO?

    Only your doctor can tell you if you have IBS. "SIBO" and "SIFO" are largely not real diagnoses. They're incorrect notions spread like wildfire on the internet for some reason... Perhaps they're easier for laypeople to grasp the notion of, and perhaps there are people profiting off of...
  19. Michael Harrop

    Study BMJ investigation on financial entanglements between FDA chiefs and the drug industry (May 2024) Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry

    https://medicalxpress.com/news/2024-05-financial-entanglements-fda-chiefs-drug.html https://www.bmj.com/content/385/bmj.q975
  20. Michael Harrop

    High opportunistic bacteria on HMorg donors' GI-MAP tests--is this "normal" for this test?

    https://humanmicrobiome.info/testing/ Most of the information on those tests is not useful or reliable, which is why they are not used or recommended for stool donor screening. I used the GI Map for some donors because it contained the recommended tests. Most of the additional information can...
  21. Michael Harrop

    Other Removing gut bacteria's potential 'safe house' (appendix) may lower risk of colorectal cancer subtype (May 2024, n=139,406) Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status

    https://medicalxpress.com/news/2024-05-gut-bacteria-potential-safe-house.html https://journals.lww.com/annalsofsurgery/abstract/9900/appendectomy_and_long_term_colorectal_cancer.870.aspx The appendix, once dismissed as an unnecessary human organ, has more recently been shown to play a role in...
  22. Michael Harrop

    My detailed experiences & lessons from 13+ different FMT donors (Jun 2018- )

    They were longer lasting because I did many more FMTs from them. The donors that caused the acute reaction had the strongest benefits, even though they were short-lived due to the single dose. None. But I'm largely ranking them according to who has the most similar stool type to those donors.
  23. Michael Harrop

    Human Microbes Extreme Success From SD_ES_2015 For Severe Anxiety, Depression, and IBS

    That sounds dangerous. The stools come split into 10 pieces. Defrost one piece before making capsules with it. If you have extra capsules from the 1 piece, re-freeze them since they'd probably melt in the refrigerator. An additional freeze-thaw cycle may decrease efficacy a bit but it's safer...
  24. Michael Harrop

    My detailed experiences & lessons from 13+ different FMT donors (Jun 2018- )

    Correct. They both triggered a reaction followed by large overall improvement, particularly to fatigue. Perhaps I downplayed it a bit but I went from laying in bed all day with eyes closed, feeling like I was dying/whole body shutting down, to being able to exercise and eat new foods without...
  25. Michael Harrop

    Study Chemicals in car interiors may cause cancer — and they’re required by US law (May 2024) Flame Retardant Exposure in Vehicles Is Influenced by Use in Seat Foam and Temperature

    https://thehill.com/policy/energy-environment/4649281-chemicals-car-interiors-cancer-required-federal-law-study/ https://pubs.acs.org/doi/10.1021/acs.est.3c10440
  26. Michael Harrop

    Antibiotics Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks (May 2024, mice)

    https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01795-z
  27. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    What is the basis for that notion? Additionally, poor engraftment can be due to a low-quality donor. And this thread is relevant as well, in regards to engraftment and FMT outcomes: https://forum.humanmicrobiome.info/threads/fmt-engraftment.372/
  28. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    What's more is that I've done the work for them -- screening a million donors. They have no excuse anymore, yet they keep on doing it. Another group just announced an FMT clinical trial on Twitter. I asked about donor quality and selection and got no response.
  29. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjae066/7665392 Yet another FMT trial harming patients and extending the unavailability of FMT due to using low-quality donors.
  30. Michael Harrop

    Considering a 5 year old girl to be a FMT donor for a 10 year old girl who has some health problems

    Make sure you do adequate learning first. Many people use donors they think are ideal and get worse because they didn't properly understand what makes an ideal stool donor. Stool type/characteristics seem to be one of the more important aspects. You can start here...
  31. Michael Harrop

    Donors' lab test results for humanmicrobes.org?

    There's a donor list with all the info on each donor, including the test results. You can email Human Microbes directly for that info.
  32. Michael Harrop

    Vaccines Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? (May 2024, NYT) All vaccines have at least occasional side effects. But people who say they were injured by Covid vaccines believe their cases have been ignored.

    https://www.nytimes.com/2024/05/03/health/covid-vaccines-side-effects.html I've seen this same attitude and dismissal when the harms of antibiotics are brought up in laypeople communities.
  33. Michael Harrop

    FMT engraftment

    There is some coverage of this in the FMT wiki page under "Outcomes" https://humanmicrobiome.info/fmt/#outcomes. It includes this recent thread with discussion & links: https://forum.humanmicrobiome.info/threads/variability-of-strain-engraftment-and-predictability-of-microbiome-com.325/post-721...
  34. Michael Harrop

    Prebiotics Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model (Mar 2024) Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation

    https://medicalxpress.com/news/2024-05-common-fiber-trigger-bowel-inflammation.html https://rupress.org/jem/article-abstract/221/5/e20232148/276641/Dietary-fiber-is-a-critical-determinant-of Another example of possible detriments from prebiotics https://humanmicrobiome.info/prebiotics/#detriments.
  35. Michael Harrop

    Oral Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes (May 2024)

    https://www.nature.com/articles/s41564-024-01680-3 A useful addition to the "Does the oral microbiome colonize the gut?" question.
  36. Michael Harrop

    Early development Father's gut microbes affect the next generation (May 2024, mice) Paternal microbiome perturbations impact offspring fitness

    https://medicalxpress.com/news/2024-05-father-gut-microbes-affect-generation.html https://www.nature.com/articles/s41586-024-07336-w
  37. Michael Harrop

    Early life antibiotics and gut microbiome

    Yes, they definitely can. There's a whole wiki page on this: https://humanmicrobiome.info/maternity/ Antibiotics at any point in life do long-term damage. Early life may be the most damaging though.
  38. Michael Harrop

    Phages A virus could help save billions of gallons of wastewater produced by fracking (Mar 2024) Using Bacteriophages to Treat Resilient Bacteria Found in Produced Water

    https://www.eurekalert.org/news-releases/1042964 https://www.mdpi.com/2073-4441/16/6/797
  39. Michael Harrop

    Article Multicellular Bacteria Evolve Defenses that Resemble the Immune System (Apr 2024)

    https://www.the-scientist.com/multicellular-bacteria-evolve-defenses-that-resemble-the-immune-system-71807
  40. Michael Harrop

    I believe you're referring to my UT-AW report...

    I believe you're referring to my UT-AW report https://forum.humanmicrobiome.info/threads/humanmicrobes-org-donor-ut-aw-1998-no-improvement-for-ibs-d-cfs-mild-a.102/, and that was pure speculation.
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