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  1. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    This video was a good reminder of another possible reason Congresspeople have done nothing about this -- personal investments in the stock market (the pharmaceutical industry). https://www.youtube.com/watch?v=BsrAZ0gnkPo
  2. Michael Harrop

    Oral microbiome - Streptococcus overgrowth (test results)

    It sounds like you didn't read the stickied post: https://forum.humanmicrobiome.info/threads/before-you-post-or-comment-here-please-review-the-testing-page-of-the.24/
  3. Michael Harrop

    STICKY Before you post or comment here, please review the Testing page of the wiki to understand what these tests can and cannot do, and what kind of feedback you can expect to receive. Marketing is not allowed.

    Related thread: FMT, donor-matching, screening for specific microbes, and pre-treatment/eradication. "Killing things off" vs suppression & ecosystem restoration.
  4. Michael Harrop

    FMT Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies (Sept 2025)

    https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04353-y I think n=106, but they're using the word "pairs" confusingly. I don't think they gave the 24 healthy controls FMT. Donors: Doesn't say how many donors were used. Results:
  5. Michael Harrop

    Antibiotics Cecal microbiome transplantation without antibiotic preconditioning standardizes murine microbiomes (Aug 2025) "We find that antibiotic preconditioning reduces efficiency for uptake of CMT-specific strains. Antibiotics introduce uncontrolled variance in the resulting microbiome composition"

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1632210/full Another piece of evidence opposing antibiotics prior to FMT.
  6. Michael Harrop

    FMT Obese teens given healthy gut bacteria show lasting drop in diabetes risk (Aug 2025, n=55) Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up

    https://medicalxpress.com/news/2025-08-obese-teens-healthy-gut-bacteria.html https://www.nature.com/articles/s41467-025-62752-4 New Zealand group. This is a follow-up to their "gut bugs" study...
  7. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    By "can't", do you mean "shouldn't be"? There's info in this thread: https://forum.humanmicrobiome.info/threads/microbiota-therapeutics-program-mtp-at-the-university-of-minnesota-jun.1089/ - you can continue there since it's off-topic here.
  8. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    I think this is a continued misunderstanding of the situation. There is already heavy regulation that the UMN stool bank complies with. The issue is that the person running the stool bank lacks the judgment and motivation to acquire safe and effective donors.
  9. Michael Harrop

    Study Mount Sinai study supports evidence that prenatal acetaminophen use may be linked to increased risk of autism and ADHD (Aug 2025, review) Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology

    Yes, ultimately, the problem is unhealthy people using their bodies to create other people. And the primary solution is FMT.
  10. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    As I said, because they know about it and claim they want to make cures available and end chronic disease. The public doesn't need to be well-informed for the FDA, NIH, or HHS to do something about a relatively unknown treatment. There is nothing else that comes close to the power & potential of...
  11. Michael Harrop

    FMT Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial (Aug 2025, n=20)

    I'm always skeptical of adverse event tracking, but it doesn't appear they used former cancer patients as donors for this study. It appears that they used regular, healthy donors. In fact, this study provides support for the notion that you don't need to use other cancer patients as donors.
  12. Michael Harrop

    Causation Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study (Aug 2025) "Our study revealed a significant causal impact of five GM genera, 10 metabolites, two metabolite ratios, and 22 immune cells"

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1620449/full
  13. Michael Harrop

    Study Chronic Exposure to Microplastics Induces Blood–Brain Barrier Impairment, Oxidative Stress, and Neuronal Damage in Rats (Jun 2025)

    https://link.springer.com/article/10.1007/s12035-025-05157-0 https://www.psypost.org/chronic-exposure-to-microplastics-impairs-blood-brain-barrier-and-damages-neurons/
  14. Michael Harrop

    FMT Fecal Microbiota Transplantation in Patients with Alcohol-Associated Cirrhosis: A Clinical Trial (Aug 2025, n=19) "significant reduction in hepatic encephalopathy severity"

    https://www.mdpi.com/2077-0383/14/17/5981 Donors:
  15. Michael Harrop

    FMT Colonoscopic fecal microbiota transplantation for Mild-to-Moderate Parkinson’s Disease: A randomized controlled trial (Aug 2025, n=30) "alleviates motor and non-motor symptoms"

    https://www.sciencedirect.com/science/article/pii/S0889159125003216 Donor:
  16. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    I disagree that FMT is niche and inconceivable as an FDA priority. This new administration is supposed to be solving the chronic disease crisis. FMT is one of the primary tools to do so. Dr. Martin Makary is well-informed on it...
  17. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    https://jamanetwork.com/journals/jama/fullarticle/2835314 Subsections: Unleashing AI Healthier Food for Children Harnessing Big Data Financial Toxicity Sounds like more useless, distracting BS, and that they have no plans to do anything about FMT.
  18. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    Another video on it: Make America Healthy Again: Last Week Tonight with John Oliver (HBO) https://www.youtube.com/watch?v=3lzfH86avIc Much of it covers Calley and Casey Means.
  19. Michael Harrop

    Study Mount Sinai study supports evidence that prenatal acetaminophen use may be linked to increased risk of autism and ADHD (Aug 2025, review) Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology

    https://www.eurekalert.org/news-releases/1094641 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0
  20. Michael Harrop

    Article White House releases RFK Jr.-led report on chronic disease (May 2025) The MAHA Report, Make Our Children Healthy Again Assessment

    A preliminary look at their recommendations: RFK Jr.’s report on US children's health lacks major policy changes. Bad diets, too many meds, no exercise: A look inside the latest ‘Make America Healthy Again’ report. (Aug 15, 2025)...
  21. Michael Harrop

    Article Top FDA Official Resigns Under Pressure (Jul 2025) After turning down several new drugs and restricting use of another, Dr. Vinay Prasad drew the ire of the right-wing influencer Laura Loomer and others

    Ousted FDA vaccine chief Vinay Prasad is returning to the agency (Aug 11, 2025) AP https://apnews.com/article/prasad-fda-vaccines-eef30969c22d3e881341b8359f18c429 Politico has more details https://www.politico.com/news/2025/08/09/prasad-returns-to-fda-as-top-vaccine-regulator-00501342 This is...
  22. Michael Harrop

    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Yep. It seems deliberate. Here's RFK talking about the microbiome on Aug 7, yet only in regards to diet: https://x.com/SecKennedy/status/1953459656870727919 And here's Dr. Makary saying: https://x.com/DrMakaryFDA/status/1953544732296319458 It doesn't appear that we're going to get access to...
  23. Michael Harrop

    Other Where should I start before deciding if FMT could help me?

    The wiki. Because your question(s) demonstrate a severe lack of knowledge on the gut microbiome.
  24. Michael Harrop

    Study The Lancet Countdown on health and plastics (2025) "Plastics are a grave, growing, and under-recognised danger to human and planetary health"

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/abstract
  25. Michael Harrop

    Sources Purety Clinic FMT experience? | Fecal microbiota transplants

    @FibroGalinSoCal, you should submit a detailed report to the appropriate section: https://forum.humanmicrobiome.info/forums/fmt-clinics-experiences-reviews/ It helps people find experiences, determine which ones are authentic, and how likely they are to benefit or get worse from a specific source.
  26. Michael Harrop

    FMT Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial (Aug 2025, n=20)

    https://jitc.bmj.com/content/13/8/e012659
  27. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    A video on it by More Perfect Union: The Dark Secret Behind The Wellness Movement https://www.youtube.com/watch?v=CSVL8Vn7nyE
  28. Michael Harrop

    Discussion Feel free to provide feedback for a new logo

    After lots of prompting, I finally got ChatGPT to make some decent images of a petri dish, shaped like a speech bubble, with a colon speckled with microbes inside. I added them to the OP. I'm not too sure where to use them, or if I want to use them. Maybe in place of the "HM" favicon.
  29. Michael Harrop

    FMT Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial (Aug 2025, n=20) "FMT did not significantly affect hepatic steatosis, glucose tolerance, liver biochemistry, or gut microbiota signatures"

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2541035#abstract Donors: More evidence that the stool bank model and the standard donor criteria are non-viable. Zero results for "symptoms" or "adverse events". So it doesn't appear that they were tracked at all. It's incredible...
  30. Michael Harrop

    Causation Newly discovered gut bacteria proteins influence hormones, metabolism and bone density (Jul 2025, mice) Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

    https://medicalxpress.com/news/2025-07-newly-gut-bacteria-proteins-hormones.html https://www.nature.com/articles/s41564-025-02064-x
  31. Michael Harrop

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I describe it as "disruption" in my probiotic guide. I experienced something similar with olive oil.
  32. Michael Harrop

    Other What exactly is forbidden in the US with regards to FMT?

    You're welcome to try it and report your results. I wouldn't try it myself due to concerns about donor quality.
  33. Michael Harrop

    Article Top FDA Official Resigns Under Pressure (Jul 2025) After turning down several new drugs and restricting use of another, Dr. Vinay Prasad drew the ire of the right-wing influencer Laura Loomer and others

    Here's a related article by Laura Loomer: Meet Vinay Prasad: The Progressive Leftist Saboteur Undermining President Trump’s FDA https://loomered.com/2025/07/20/meet-vinay-prasad-the-progressive-leftist-saboteur-undermining-president-trumps-fda/ Most of it goes on to cover his political...
  34. Michael Harrop

    Article Top FDA Official Resigns Under Pressure (Jul 2025) After turning down several new drugs and restricting use of another, Dr. Vinay Prasad drew the ire of the right-wing influencer Laura Loomer and others

    https://www.nytimes.com/2025/07/29/health/vinay-prasad-fda-resigns-loomer.html https://archive.ph/JEveK This is big, but I'm not sure if it's good or bad for FMT. Based on the article, he seems like the kind of person who would work to make FMT available, but then again, maybe not, and he...
  35. Michael Harrop

    Other What exactly is forbidden in the US with regards to FMT?

    The "paying so much" was due to the inability to recruit effective donors. Removing all mention of FMT and making it unclear what we want their poop for would only make things exponentially more difficult.
  36. Michael Harrop

    Other What exactly is forbidden in the US with regards to FMT?

    You cannot prescribe unapproved drugs. Doctors need an IND if they want to try FMT on a patient. You can see the exact issues in the FDA warning letter: https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/human-microbes-672740-02092024 The primary...
  37. Michael Harrop

    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    Ok, here's the plan: I don't think it's going to be useful to tweet at (& like) famous people unless you have hundreds of people participating. If you can find smaller targets that are more likely to pay attention to a tweet with a handful of likes, we can try it. I plan to start recording...
  38. Michael Harrop

    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    You just trusted him with that statement. The patterns you're looking at are ridiculously oversimplistic, and it's been explained to you in detail in the past. You've opted to ignore plausible reasons and continue pressing debunked ones. I think you're being far too generous. A donor having a...
  39. Michael Harrop

    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Significantly worse from DF3, some improvements from DF5.

    Interesting. So, suppliers of an unregulated, potentially deadly medical product lying to their customers is not relevant to @SFBayFMT5. I can't say I'm surprised at your comment, given your behavior here over the past few months. But it should be enlightening for other people who haven't seen...
  40. Michael Harrop

    Study Breakthrough as two FDA-approved drugs (letrozole and irinotecan) are found to reverse Alzheimer’s — including restoring memory (Jul 2025, mice) Cell-type-directed network-correcting combination therapy for Alzheimer’s disease

    You can email them and ask. There are two emails listed for the authors.
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