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  1. Michael Harrop

    FMT Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability (Jul 2025, n=12, enema over 6 mo, Biomebank) No significant motor symptom changes. No sustained improvement in non-motor symptoms.

    https://www.nature.com/articles/s41531-025-01061-5 Australian group that used the TGA-approved, GMP stool bank. More evidence that GMP stool banks are not valid approaches to FMT.
  2. Michael Harrop

    Article Inside the Collapse of the F.D.A. How the new health secretary, Robert F. Kennedy Jr., is dismantling the agency (Jul 2025)

    https://www.nytimes.com/2025/07/08/magazine/fda-collapse-rfk-kennedy.html Includes some comments by the former FDA commissioner, Robert Califf. And ends with: NYT's article title is blaming RFK for cuts he wasn't responsible for. As far as I know, it was DOGE and the Office of Management...
  3. Michael Harrop

    Testing Blood Test Spots Early Cancer with 95% accuracy Using Gut Bacteria RNA (Jul 2025) Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

    https://scienceblog.com/blood-test-spots-early-cancer-using-gut-bacteria-rna/ https://www.nature.com/articles/s41587-025-02731-8
  4. Michael Harrop

    Review Weedkiller ingredient banned in the UK, EU, China, but widely used in US can damage organs and gut bacteria (May 2025, review) Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

    https://www.theguardian.com/environment/2025/jul/06/weedkiller-diquat-organ-damage-study https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1562182/full
  5. Michael Harrop

    FMT Gut Microbiome rewiring via fecal transplants: Uncovering therapeutic avenues in Alzheimer’s disease models (Jul 2025, mice) FMT from AD to healthy mice induced profound memory impairment and cognitive deficits. FMT from healthy mice yielded remarkable behavioral improvements

    https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00953-9
  6. Michael Harrop

    FMT Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study (Jul 2025, n=22) 68.1% reduction in urinary infectious episodes, eradication of fecal colonization of urinary pathogens that were resistant to multiple antibiotics

    https://link.springer.com/article/10.1007/s10096-025-05202-9 Almost no donor info:
  7. Michael Harrop

    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    https://www.nytimes.com/2025/07/02/health/ai-chatgpt-research-papers.html https://www.science.org/doi/10.1126/sciadv.adt3813 I think this is a huge problem given how flawed the peer review system is. I highly doubt that peer review is able to adequately fact-check the papers and all the...
  8. Michael Harrop

    Article Trump’s First EPA Promised to Crack Down on Forever Chemicals. His Second EPA Is Pulling Back (Jun 2025)

    https://www.propublica.org/article/trump-epa-pfas-drinking-water
  9. Michael Harrop

    Study Certain species of microbe found in the human gut can absorb PFAS (Jul 2025) Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances

    https://phys.org/news/2025-06-species-microbe-human-gut-absorb.html https://www.cam.ac.uk/research/news/gut-microbes-could-protect-us-from-toxic-forever-chemicals https://www.nature.com/articles/s41564-025-02032-5
  10. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    https://boingboing.net/2025/06/27/rfk-jrs-maga-project-funnels-millions-from-public-health-to-private-wellness-industry.html https://www.accountabilityjournalism.org/insights/mahas-goal-is-not-health Some parts seem concerning. Other parts are written to raise concern, but aren't necessarily...
  11. Michael Harrop

    Causation Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation (Jun 2025, mice) Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry

    Study: https://www.nature.com/articles/s41586-025-09120-w Commentary: https://www.nature.com/articles/s41577-025-01201-1
  12. Michael Harrop

    Early development U.S. Babies Are Missing a Key Gut Microbe, Fueling Allergy Risk (Jun 2025, n=412) Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis

    https://gizmodo.com/study-says-u-s-babies-are-missing-a-key-gut-microbe-fueling-allergy-risk-2000619622 https://www.nature.com/articles/s42003-025-08274-7
  13. Michael Harrop

    Other 'Microbial Noah's Ark' ramps up to save Earth's invisible life forms (Jun 2025) The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

    https://phys.org/news/2025-06-microbial-noah-ark-ramps-earth.html https://www.nature.com/articles/s41467-025-61008-5 It's a follow-up to this: Preserving microbial diversity (Oct 2018)
  14. Michael Harrop

    Article US FDA Makary’s Pharma CEO Tour Goes Against Transparency Rhetoric (May 2025) CEO Forums: An FDA Listening Tour to Engage Pharma CEOs

    https://insights.citeline.com/pink-sheet/agency-leadership/us-fda/us-fda-makarys-pharma-ceo-tour-goes-against-transparency-rhetoric-3E5RP5IATVD73DRPQHZPSTHKRA/ https://www.fda.gov/industry/ceo-forums-fda-listening-tour-engage-pharma-ceos Related: FDA Commissioner Marty Makary Announces Major...
  15. Michael Harrop

    Article FDA Commissioner Marty Makary Announces Major New Policy to Limit Conflicts of Interest (Apr 2025) "we are removing industry members – pharma members – from FDA advisory committees"

    https://www.megynkelly.com/2025/04/17/marty-makary-announces-policy-to-limit-big-pharma-conflicts-of-interest-at-fda/
  16. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx The usual poor donor criteria. Sometimes low-quality donors turn out worse than other times.
  17. Michael Harrop

    Study Glass bottles found to contain more microplastics than plastic bottles; mostly from the plastic paint on the caps (May 2025) Microplastic contaminations in a set of beverages sold in France

    https://phys.org/news/2025-06-glass-bottles-microplastics-plastic.html https://www.sciencedirect.com/science/article/pii/S0889157525005344
  18. Michael Harrop

    Causation Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis (Mar 2025)

    https://www.psypost.org/gut-bacteria-may-play-a-causal-role-in-obsessive-compulsive-disorder-study-suggests/ https://www.sciencedirect.com/science/article/abs/pii/S0165032725003167
  19. Michael Harrop

    Aging Causal Analysis Between Gut Microbes, Aging Indicator, and Age-Related Disease, Involving the Discovery and Validation of Biomarkers (Apr 2025) "Gut microbiota a potential risk factor for 14 age-related diseases. Exhibit biomarker properties for disease prediction"

    https://www.fightaging.org/archives/2025/06/evidence-of-causation-in-human-data-on-the-gut-microbiome-and-age-related-conditions/ https://onlinelibrary.wiley.com/doi/10.1111/acel.70057
  20. Michael Harrop

    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2508950 UMN GMP stool bank provides insights from their and other companies' experiences. UMN appears to have some of the worst donors that exist anywhere. Interestingly, they mention relevant info about the donor recruitment, payment...
  21. Michael Harrop

    Article The Secret Gamble at the FDA That Exposed Americans to Risky Drugs (Jun 2025) Factories, mostly in India, where inspectors found contaminated drugs, filthy labs, and falsified records, were given a pass to continue sending drugs to the US.

    https://www.propublica.org/article/fda-drug-loophole-sun-pharma
  22. Michael Harrop

    Other H. Pylori bacteria that causes stomach ulcers may protect the brain from Alzheimer’s and Parkinson’s (Jun 2025) Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

    https://theconversation.com/alzheimers-bacteria-that-cause-stomach-ulcers-may-protect-the-brain-our-new-research-indicates-259018 https://www.science.org/doi/10.1126/sciadv.ads7525
  23. Michael Harrop

    FMT Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection: A Randomized Controlled Trial (Jun 2025, n=104) "Clinical cure with no recurrence seen in 67% for FMT vs 61% for vancomycin. Up to 78% for FMT with additional treatment"

    https://www.acpjournals.org/doi/10.7326/ANNALS-24-03285 This is a unique study because usually FMT is only given after antibiotics fail.
  24. Michael Harrop

    Discussion Feel free to provide feedback for a new logo

    I saw an article that said ChatGPT is still the best at creating images. So I gave it various prompts, which resulted in these mockups, but I'm not a huge fan of any of them: I prompted it to "Make the head a petri dish that looks like a speech bubble", but it had trouble doing that. I like...
  25. Michael Harrop

    Article Dwayne 'The Rock' Johnson reveals surprising health battle and how he fought back (Jun 2025) "digestive issues linked to prior courses of antibiotics"

    https://archive.ph/MoK5H https://www.thenews.com.pk/latest/1321180-dwayne-johnson-reveals-shocking-battle-with-years-of-health-problems Interesting article with some important info and some pseudoscience. The first part is alarmingly common, and a major root cause of the chronic disease...
  26. Michael Harrop

    FMT The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study (Jun 2025, n=172). Partial remission 55%, complete remission 32% for resistance training group, and 67% partial, 45% complete for FMT+resistance group

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06557-5
  27. Michael Harrop

    FMT Fulminant Clostridioides difficile Infection Following Fecal Microbiota Spores Compared to Fecal Microbiota Transplant (May 2025, n=130) Patients receiving VOUST's fecal microbiota spores live-brpk were more likely to develop severe disease, called fulminant C. diff infection

    https://www.newswise.com/articles/new-treatment-for-c-diff-infection-may-be-less-effective-than-traditional-therapy-study-finds/ https://www.cghjournal.org/article/S1542-3565(25)00420-3/abstract Closed access.
  28. Michael Harrop

    FMT Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results (Jun 2025, n=4) "FMT through colonoscopy showed improvement in pain, bloating, and stool consistency that was maintained during the 6-month follow-up"

    https://www.sciencedirect.com/science/article/pii/S2255534X25000647
  29. Michael Harrop

    Probiotics Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial (Jun 2025, n=190) "incidence of POCD in the probiotic group was significantly lower than in the control group"

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06584-2
  30. Michael Harrop

    Study Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs (Jun 2025, mice)

    https://www.nature.com/articles/s41467-025-59884-y
  31. Michael Harrop

    Causation Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study (Jun 2025)

    https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-025-03789-x
  32. Michael Harrop

    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    https://www.dw.com/en/fecal-transplants-study-is-a-wake-up-call-for-the-field/a-72817699 https://www.the-independent.com/news/health/fecal-transplants-consequences-research-us-b2765279.html...
  33. Michael Harrop

    FMT Public knowledge, awareness and perception of gut microbiome and faecal microbiota transplantation in Singapore: a survey study (Jun 2025, n=1831) "33% had heard of the gut microbiome, 92% had consumed probiotics, 85% had not heard of FMT, 72% would consider FMT to treat C. diff"

    https://journals.lww.com/smj/fulltext/9900/public_knowledge,_awareness_and_perception_of_gut.196.aspx
  34. Michael Harrop

    Article Kennedy Says ‘Charlatans’ Are No Reason to Block Unproven Stem Cell Treatments. The U.S. health secretary said people should have access to experimental therapies including unregulated uses of stem cells. But some methods have resulted in blindness, tumors and other injuries. (Jun 2025)

    https://www.nytimes.com/2025/06/05/health/kennedy-stem-cells-experimental-treatments.html
  35. Michael Harrop

    Antibiotics Human antibiotics are polluting Earth's rivers, helping bacteria develop the resistance they need to then kill humans (Apr 2025) Antibiotics in the global river system arising from human consumption

    https://www.earth.com/news/earth-rivers-are-highly-saturated-with-human-antibiotics-helping-bacteria-develop-resistance/ https://academic.oup.com/pnasnexus/article/4/4/pgaf096/8113371
  36. Michael Harrop

    Oral Causal association between oral microbiota and oral cancer: a mendelian randomization study (Jun 2025) "Our findings suggest that Prevotella and Veillonella were causally linked to OC"

    https://www.nature.com/articles/s41598-025-05553-5
  37. Michael Harrop

    FMT Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice (Jun 2025) "human-derived microbiota was less effective in clearing C. difficile compared to a mouse-derived microbiota"

    https://journals.asm.org/doi/10.1128/mbio.01108-25
  38. Michael Harrop

    Article Over the last several decades, the FDA has allowed pharma companies to sell hundreds of drugs to patients without adequate evidence that they work and, in many cases, with clear signs that they pose a risk of serious harm (Jun 2025)

    https://jacobin.com/2025/06/fda-approval-drugs-effectiveness-risk/
  39. Michael Harrop

    FMT Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis (Jun 2025, n=27) "the effect depends on the specific donor microbiota and not on patient fiber use"

    https://www.cell.com/med/abstract/S2666-6340(25)00134-5
  40. Michael Harrop

    FMT Donor-derived microbial engraftment and gut microbiota shifts associated with weight loss following fecal microbiota transplantation (Jun 2025, n=23) "52% achieved weight loss of more than 5% from baseline. Average weight loss of 8kg/18lbs"

    https://journals.asm.org/doi/10.1128/aem.00120-25 Chinese study. 52% achieved weight loss of more than 5% from baseline. Average weight loss of 8kg (18 lbs). Nonresponders lost 3kg. Contrary to some other studies, they found engraftment to correlate with success. Donors: But they couldn't...
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