Search results for query: *

Forum search Google search

  1. Michael Harrop

    FMT Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies (Sept 2025)

    https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04353-y I think n=106, but they're using the word "pairs" confusingly. I don't think they gave the 24 healthy controls FMT. Donors: Doesn't say how many donors were used. Results:
  2. Michael Harrop

    Antibiotics Cecal microbiome transplantation without antibiotic preconditioning standardizes murine microbiomes (Aug 2025) "We find that antibiotic preconditioning reduces efficiency for uptake of CMT-specific strains. Antibiotics introduce uncontrolled variance in the resulting microbiome composition"

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1632210/full Another piece of evidence opposing antibiotics prior to FMT.
  3. Michael Harrop

    FMT Obese teens given healthy gut bacteria show lasting drop in diabetes risk (Aug 2025, n=55) Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up

    https://medicalxpress.com/news/2025-08-obese-teens-healthy-gut-bacteria.html https://www.nature.com/articles/s41467-025-62752-4 New Zealand group. This is a follow-up to their "gut bugs" study...
  4. Michael Harrop

    Causation Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study (Aug 2025) "Our study revealed a significant causal impact of five GM genera, 10 metabolites, two metabolite ratios, and 22 immune cells"

    https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1620449/full
  5. Michael Harrop

    Study Chronic Exposure to Microplastics Induces Blood–Brain Barrier Impairment, Oxidative Stress, and Neuronal Damage in Rats (Jun 2025)

    https://link.springer.com/article/10.1007/s12035-025-05157-0 https://www.psypost.org/chronic-exposure-to-microplastics-impairs-blood-brain-barrier-and-damages-neurons/
  6. Michael Harrop

    FMT Fecal Microbiota Transplantation in Patients with Alcohol-Associated Cirrhosis: A Clinical Trial (Aug 2025, n=19) "significant reduction in hepatic encephalopathy severity"

    https://www.mdpi.com/2077-0383/14/17/5981 Donors:
  7. Michael Harrop

    FMT Colonoscopic fecal microbiota transplantation for Mild-to-Moderate Parkinson’s Disease: A randomized controlled trial (Aug 2025, n=30) "alleviates motor and non-motor symptoms"

    https://www.sciencedirect.com/science/article/pii/S0889159125003216 Donor:
  8. Michael Harrop

    Article Priorities for a New FDA | Martin Makary, Vinay Prasad (Jun 2025)

    https://jamanetwork.com/journals/jama/fullarticle/2835314 Subsections: Unleashing AI Healthier Food for Children Harnessing Big Data Financial Toxicity Sounds like more useless, distracting BS, and that they have no plans to do anything about FMT.
  9. Michael Harrop

    Study Mount Sinai study supports evidence that prenatal acetaminophen use may be linked to increased risk of autism and ADHD (Aug 2025, review) Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology

    https://www.eurekalert.org/news-releases/1094641 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0
  10. Michael Harrop

    Study The Lancet Countdown on health and plastics (2025) "Plastics are a grave, growing, and under-recognised danger to human and planetary health"

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/abstract
  11. Michael Harrop

    FMT Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial (Aug 2025, n=20)

    https://jitc.bmj.com/content/13/8/e012659
  12. Michael Harrop

    FMT Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial (Aug 2025, n=20) "FMT did not significantly affect hepatic steatosis, glucose tolerance, liver biochemistry, or gut microbiota signatures"

    https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2541035#abstract Donors: More evidence that the stool bank model and the standard donor criteria are non-viable. Zero results for "symptoms" or "adverse events". So it doesn't appear that they were tracked at all. It's incredible...
  13. Michael Harrop

    Causation Newly discovered gut bacteria proteins influence hormones, metabolism and bone density (Jul 2025, mice) Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

    https://medicalxpress.com/news/2025-07-newly-gut-bacteria-proteins-hormones.html https://www.nature.com/articles/s41564-025-02064-x
  14. Michael Harrop

    Article Top FDA Official Resigns Under Pressure (Jul 2025) After turning down several new drugs and restricting use of another, Dr. Vinay Prasad drew the ire of the right-wing influencer Laura Loomer and others

    https://www.nytimes.com/2025/07/29/health/vinay-prasad-fda-resigns-loomer.html https://archive.ph/JEveK This is big, but I'm not sure if it's good or bad for FMT. Based on the article, he seems like the kind of person who would work to make FMT available, but then again, maybe not, and he...
  15. Michael Harrop

    Article FDA names former pharmaceutical company executive, Dr. George Tidmarsh, to oversee US drug program, CDER (2025)

    https://apnews.com/article/fda-drugs-trump-makary-george-tidmarsh-88471eab7dcaf1ab8cc4dd2491218120 No mention of scrutinizing the safety of antibiotics, even though Dr. Makary is well-informed on their harms and their contribution to the chronic disease crisis.
  16. Michael Harrop

    Study Patient Advocacy Organizations: Institutional Conflicts of Interest, Trust, and Trustworthiness (2013)

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4107906/ I've spent the past 10 months living in my car in DC, visiting the Congressional offices most days. I've seen lots of Patient Advocacy Orgs (PAOs) here. A few Congresspeople recommended I contact PAOs. I was already contacting every PAO I came...
  17. Michael Harrop

    Aging Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization (Jul 2025)

    https://link.springer.com/article/10.1007/s11357-025-01794-4
  18. Michael Harrop

    Other Previously undetectable biomarkers in gut microbiome may predict 'invisible' chronic fatigue syndrome, long COVID (Jul 2025, n=249) AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome

    https://medicalxpress.com/news/2025-07-previously-undetectable-biomarkers-gut-microbiome.html#google_vignette https://www.nature.com/articles/s41591-025-03788-3
  19. Michael Harrop

    Antibiotics Influence of perinatal antibiotic on neonatal gut microbiota: a prospective cohort study (Jul 2025, n=182) "perinatal antibiotic exposure is associated with significant changes in the neonatal gut microbiota, potentially increasing the pathogenic microbiota"

    https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-025-05907-y
  20. Michael Harrop

    Probiotics Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment (Jul 2025, mice) Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains

    https://news.ncsu.edu/2025/07/probiotics-can-help-or-hinder-gut-recovery-after-antibiotic-treatment/ https://journals.asm.org/doi/10.1128/mbio.01468-25
  21. Michael Harrop

    There is a bug where replies to threads don't result in notifications/alerts being sent, and the thread and subforum do not get bolded

    The only solution right now is to keep an eye on the "what's new" section.
  22. Michael Harrop

    Other Microbiome disruption by common drugs raises new safety concerns. Nearly 1/3 of the tested non-antibiotic drugs disrupt gut microbiota, weakening natural defenses and promoting harmful bacteria like Salmonella (Jul 2025, mice) Non-antibiotics disrupt colonization resistance against enteropathogens

    https://analyticalscience.wiley.com/content/news-do/microbiome-disruption-common-drugs-raises-new-safety-concerns https://www.nature.com/articles/s41586-025-09217-2 There have been a number of similar studies: https://humanmicrobiome.info/intro/#drugs-impacts-on-the-gut-microbiome
  23. Michael Harrop

    The power of olive oil -- significant changes to gut microbiome, stool, and food tolerances

    Back in 2018 I posted that Olive oil might be something to consider prior to FMT. Then, over the past year, I've had somewhat of an opposite experience. I've had olive oil as part of my diet for many years now. When I left home for DC, I had to change my diet since I could no longer cook...
  24. Michael Harrop

    FMT Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability (Jul 2025, n=12, enema over 6 mo, Biomebank) No significant motor symptom changes. No sustained improvement in non-motor symptoms.

    https://www.nature.com/articles/s41531-025-01061-5 Australian group that used the TGA-approved, GMP stool bank. More evidence that GMP stool banks are not valid approaches to FMT.
  25. Michael Harrop

    Article Inside the Collapse of the F.D.A. How the new health secretary, Robert F. Kennedy Jr., is dismantling the agency (Jul 2025)

    https://www.nytimes.com/2025/07/08/magazine/fda-collapse-rfk-kennedy.html Includes some comments by the former FDA commissioner, Robert Califf. And ends with: NYT's article title is blaming RFK for cuts he wasn't responsible for. As far as I know, it was DOGE and the Office of Management...
  26. Michael Harrop

    Testing Blood Test Spots Early Cancer with 95% accuracy Using Gut Bacteria RNA (Jul 2025) Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

    https://scienceblog.com/blood-test-spots-early-cancer-using-gut-bacteria-rna/ https://www.nature.com/articles/s41587-025-02731-8
  27. Michael Harrop

    Review Weedkiller ingredient banned in the UK, EU, China, but widely used in US can damage organs and gut bacteria (May 2025, review) Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

    https://www.theguardian.com/environment/2025/jul/06/weedkiller-diquat-organ-damage-study https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1562182/full
  28. Michael Harrop

    FMT Gut Microbiome rewiring via fecal transplants: Uncovering therapeutic avenues in Alzheimer’s disease models (Jul 2025, mice) FMT from AD to healthy mice induced profound memory impairment and cognitive deficits. FMT from healthy mice yielded remarkable behavioral improvements

    https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00953-9
  29. Michael Harrop

    FMT Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study (Jul 2025, n=22) 68.1% reduction in urinary infectious episodes, eradication of fecal colonization of urinary pathogens that were resistant to multiple antibiotics

    https://link.springer.com/article/10.1007/s10096-025-05202-9 Almost no donor info:
  30. Michael Harrop

    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    https://www.nytimes.com/2025/07/02/health/ai-chatgpt-research-papers.html https://www.science.org/doi/10.1126/sciadv.adt3813 I think this is a huge problem given how flawed the peer review system is. I highly doubt that peer review is able to adequately fact-check the papers and all the...
  31. Michael Harrop

    Article Trump’s First EPA Promised to Crack Down on Forever Chemicals. His Second EPA Is Pulling Back (Jun 2025)

    https://www.propublica.org/article/trump-epa-pfas-drinking-water
  32. Michael Harrop

    Study Certain species of microbe found in the human gut can absorb PFAS (Jul 2025) Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances

    https://phys.org/news/2025-06-species-microbe-human-gut-absorb.html https://www.cam.ac.uk/research/news/gut-microbes-could-protect-us-from-toxic-forever-chemicals https://www.nature.com/articles/s41564-025-02032-5
  33. Michael Harrop

    Article RFK Jr's MAHA project funnels millions from public health to private wellness industry (Jun 2025) MAHA’s Goal Is Not Health. Robert Kennedy’s movement promises more privatization

    https://boingboing.net/2025/06/27/rfk-jrs-maga-project-funnels-millions-from-public-health-to-private-wellness-industry.html https://www.accountabilityjournalism.org/insights/mahas-goal-is-not-health Some parts seem concerning. Other parts are written to raise concern, but aren't necessarily...
  34. Michael Harrop

    Causation Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation (Jun 2025, mice) Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry

    Study: https://www.nature.com/articles/s41586-025-09120-w Commentary: https://www.nature.com/articles/s41577-025-01201-1
  35. Michael Harrop

    Early development U.S. Babies Are Missing a Key Gut Microbe, Fueling Allergy Risk (Jun 2025, n=412) Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis

    https://gizmodo.com/study-says-u-s-babies-are-missing-a-key-gut-microbe-fueling-allergy-risk-2000619622 https://www.nature.com/articles/s42003-025-08274-7
  36. Michael Harrop

    Other 'Microbial Noah's Ark' ramps up to save Earth's invisible life forms (Jun 2025) The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

    https://phys.org/news/2025-06-microbial-noah-ark-ramps-earth.html https://www.nature.com/articles/s41467-025-61008-5 It's a follow-up to this: Preserving microbial diversity (Oct 2018)
  37. Michael Harrop

    Article US FDA Makary’s Pharma CEO Tour Goes Against Transparency Rhetoric (May 2025) CEO Forums: An FDA Listening Tour to Engage Pharma CEOs

    https://insights.citeline.com/pink-sheet/agency-leadership/us-fda/us-fda-makarys-pharma-ceo-tour-goes-against-transparency-rhetoric-3E5RP5IATVD73DRPQHZPSTHKRA/ https://www.fda.gov/industry/ceo-forums-fda-listening-tour-engage-pharma-ceos Related: FDA Commissioner Marty Makary Announces Major...
  38. Michael Harrop

    Article FDA Commissioner Marty Makary Announces Major New Policy to Limit Conflicts of Interest (Apr 2025) "we are removing industry members – pharma members – from FDA advisory committees"

    https://www.megynkelly.com/2025/04/17/marty-makary-announces-policy-to-limit-big-pharma-conflicts-of-interest-at-fda/
  39. Michael Harrop

    FMT Preliminary Results From a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients With Mild-to-Moderate Crohn's Disease (Jun 2025, n=34) Terminated early due to futility.

    https://journals.lww.com/ajg/fulltext/2025/06000/preliminary_results_from_a_multicenter,_randomized.24.aspx The usual poor donor criteria. Sometimes low-quality donors turn out worse than other times.
  40. Michael Harrop

    Study Glass bottles found to contain more microplastics than plastic bottles; mostly from the plastic paint on the caps (May 2025) Microplastic contaminations in a set of beverages sold in France

    https://phys.org/news/2025-06-glass-bottles-microplastics-plastic.html https://www.sciencedirect.com/science/article/pii/S0889157525005344
Back
Top Bottom