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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Worse from DF3, better from DF5.

    Good to know that too about Microbioma. Though the situation with the Microbioma donors is confusing, I can never keep straight who is talking about whom. Because some people said there was one male donor and one female, some said there were originally two male donors but then they got a third...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    I don't see how using AI in this way would provide any more information than one would get by merely searching the literature using a conventional search engine. LLMs have pretty conclusively demonstrated their inability to rank the relative credibility of sources better than a human could...
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    Gezonde Darmflora Experience with two Gezonde Darmflora donors. Worse from DF3, better from DF5.

    Good too see someone else had a similar worsening from DF3, so it's not "just me". Not in the sense that it's good to see people get worse, but in that it's not that I am the only one made worse by a donor who is great for everyone else. It's also interesting to see that DF5, who Marco said was...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    Does it return ONLY that study though, or (as I would suspect) that study in a long list of other studies? The factor at play here is nothing to do with censorship. It has to do with the models associating collection of words in a certain order. The model doesn't actually know what "curing...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    Why would this have anything to do with being "censored" or not? AI "censoring" relates to the prevention of the model returning unethical, bigoted, or harmful (i.e. advocacy of suicide and/or violence) outputs, or in the case of image models, generating NSFW images. I have never heard of an AI...
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    Article Finch wins US jury trial against Ferring over fecal-transplant patents (Aug 2024, Rebyota)

    From the prescribing information, "Description" (Section 11): https://www.ferringusa.com/wp-content/uploads/sites/12/2022/12/9009000002_REBYOTA-PI_11-2022.pdf "REBYOTA (fecal microbiota, live – jslm) is an opaque fecal microbiota suspension for rectal administration. REBYOTA is manufactured...
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    Article F.D.A. to Use A.I. in Drug Approvals to ‘Radically Increase Efficiency’. With a Trump-driven reduction of nearly 2,000 employees, agency officials view artificial intelligence as a way to speed drugs to the market. (Jun 2025)

    This sounds like complete empty hype. There have been data-driven, machine learning-based predictors for toxicity, oral absorption and blood brain barrier permeability, stability in blood, and similar ADME-type measures for years, and these haven't really made much of a difference in the amount...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    How long did the benefit last from the garlic and oregano? My experience with things that kill bacteria (whether antibiotics or herbs) is that even if they cause a change in the beginning, that change is lost within a week or so, even if I continue taking the medication or supplement (or go back...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    It would be GREAT if more of the scientific community started talking about gut bacteria "for real" as you put it. But if the conclusions are what you are imagining (that specific species are "blamed" for diseases, as opposed to the lack of certain species causing diseases), then the cure that...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I have heard secondary reports of "Lactobacillus SIBO" where the only organism found in greater-than-normal numbers in the small intestine is a species of Lactobacillus (i.e. no significant elevation in any Enterobacteriaceae, Streptococcus, Bacteroides etc.) but never any literature. I...
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    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    How would you know, since you only test your donors once? All Gezonde Darmflora donors except for DF6, their newest donor, have failed a stool test at one time or another, since they are tested monthly--however their overall probability of testing positive on any given test is low. Most months...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I watched that video and I think I see what's going on. There's a lot of that in the science communication world. Basically, it's an alliance of science and a very "conservative" type of "alternative" health, where researchers come out and act as if they are starting "a revolution" when in fact...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I think what we're running up against is a sort of "Catch 22" where most people don't try FMT because it's not readily available, and so then you don't have huge groups of people with success stories to tell who would sign petitions like this. Add to that the fact that even among those who DO...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    First the good: I REALLY appreciate the attempt to include a broader range of bacterial diversity (both genetic and functional) than the vast majority of other probiotics. We have one sugar fermenting lactic acid bacterium (Enterococcus), one "secondary fermenter" that utilizes the lactate...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Who is most important for us to contact at this point?
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    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    “There are microbes along the entire intestinal tract, and we just study predominately the last third of it (the colon),” DeLeon said. I've been saying this for years as well! That almost the entire research on the gut is focused on the large intestine, which in turn means largely on just two...
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    Early development In utero human intestine contains maternally derived bacterial metabolites (May 2025, n=21)

    From the very first sentence of the Methods section: "Placental and fetal samples were obtained from the University of Pittsburgh Biospecimen Core from electively terminated products of conception (14–23 weeks of gestation)" So indigo34 was correct--these were aborted fetuses.
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    Oral Swapping spit with your spouse may spread anxiety and depression (Apr 2025, 536 couples) Oral Microbiota Transmission Partially Mediates Depression and Anxiety in Newlywed Couples

    Interesting--I'm not too surprised.
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    Gezonde Darmflora Improvements to sleep, IBS, and weight from donor DF3 from Gezonde Darmflora

    Just so everyone here knows who might be thinking of trying her, DF3 is unfortunately no longer available How did you confirm a Lyme relapse? Did you have a recurrence of arthritis, a bull's eye rash, or some other specific Lyme symptom? In my experience, not only is it difficult to tell many...
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    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    Recently posted by someone in another FMT group. https://www.cell.com/cell/abstract/S0092-8674(25)00564-1 "Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    MANY bacteria, including many probiotic strains, produce histamine. This is well studied--there are apparently probiotics that are supposed to contain low-histamine strains.
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    Enhancing Antifreeze in stool/FMT capsules, glycerol vs maltodextrin, -80 (medical freezer) vs -20 (home freezer)

    I'm wondering what were the alternatives/comparison groups.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Responded here: https://forum.humanmicrobiome.info/threads/thoughts-on-humanmicrobes-donor-problem.163/post-2528
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    Donors Thoughts on HumanMicrobes donor problem

    They may not look at stool type like you do, but they have looked at other things, in particular: -Use of proton pump inhibitors prior to upper route (Answer... it seems it's not very important, I think they even don't do it anymore) -Use of vancomycin pretreatment (Answer: improves the success...
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    Procedure Getting blood and stool testing for an FMT donor

    For those who found themselves private donors, when it came time to get the bloodwork done, how did you do it? Did you give the donor the list of tests and have him/her contact his/her doctor to get them ordered, then reimburse? or did you find a doctor online who would order them for the donor...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Arizona State University has been doing FMT studies in kids with ASD for years. They found benefits. It hasn't translated yet into the treatment being widely available for ASD kids though.
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    FMT VA trial using the University of Minnesota's donors, finds no reduction in C diff recurrence after FMT (Sep 2024, n=153, UMN) A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection

    When I got my OpenBiome FMT, it was at most 48 hours prior to the procedure that I was instructed to stop taking vancomycin. It might have even been only 24 hours, and yet however long it was, it still perfectly did its job breaking the cycle of C. diff recurrences. It also did a lot of other...
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    State of microbiome-based therapies 5-10 years from now?

    If your experience contradicts this, then that again shows how poorly your reports convey what various treatments did for you, because as I understand them by reading, nothing in your descriptions in any way goes against what I said above. First there was the fact that the four donors who...
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    Comparative study of H pylori and Streptococcus anginosus on genomes based

    You might be better off asking in a computational biology forum like Biostars or r/bioinformatics, but what are you looking to do? Are you looking to take genomes of new strains that lack gene annotations and find genes in there? or is knowing the pathways from the genomes of reference strains...
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    State of microbiome-based therapies 5-10 years from now?

    The microbiome DOES have a profound effect on mental, in addition to just physical health. However, not in the way you imagine if you are seriously asking yourself questions like this. I thought of this before my very first FMT (and before some other interventions before that)--I am on the...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    The thing is, their hands are tied as well (in the US). Doctors and other medical professionals who promote FMT for conditions other than C. diff risk disciplinary action up to eventually losing their medical licenses if they persist. By "promote" here I mean not just to state they believe in...
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    Early development Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort (Mar 2025, n=36)

    It's interesting that they only found bacteria negatively associated with normal development, and none positively associated. However they found increased diversity associated with normal development, which suggests that maybe normal development is promoted by a large variety of different...
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    Procedure DIY FMT Beginner's Questions

    Just to add something to 2: In my case, improvement continues for at least a month if not longer after FMT. After my most successful FMT, there were a number of clear immediate (same day/week, this was an endoscopy procedure) changes, but the most dramatic changes happened right around the six...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    I do see that you already cite this 2018 in your probiotic page--good for you! But do you mean you had already concluded this BEFORE 2018? If so, was it based on an even earlier study, or simply on your own experience and testimonials from other patients? If the latter, then you do deserve...
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    FMT FDA sent MG Infusions a warning letter; website is down. (Mar 2025)

    "I see that they do send warning letters to people outside the US." What force does this have? Does this mean that if the foreign seller doesn't comply, that anything coming into the US from such a seller will be seized and destroyed? In any case, this obviously confirms the FDA is back up and...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Also, did you see the reference about probiotics cited in that article (Ref #2)? I only noticed it just now, but it's informative. The conclusion of that one was that probiotics actually delay recovery of the gut microbiome after antibiotics, relative to taking nothing except the antibiotics...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Too late for us whose guts are already messed up, but hopefully this will be around for patients in the future! It's an engineered strain of yeast that destroys antibiotics in the gut before they have a chance to deplete the intestinal microbiome.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    So basically he is concerned with health care, or at least claims to be, but only so far as to help people afford conventional treatments like pharmaceuticals? Rather than accuse people of being frauds, your message should be that there is an effective treatment that is banned by the...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is that relevant to FMT? I'm assuming this was a hearing relating to health policy? If so, getting the serious attention of anyone in those hearings could be a win, even if it's only a few people. If this hearing was on an unrelated topic, then obviously it wasn't a good place to bring up...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is the campaigning in DC going?
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