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    FMT Microbiota Therapeutics Program (MTP) at the University of Minnesota (Jun 2025, UMN) Donor-centric administration of the stool donor program is vital to its feasibility and patient safety

    How would you know, since you only test your donors once? All Gezonde Darmflora donors except for DF6, their newest donor, have failed a stool test at one time or another, since they are tested monthly--however their overall probability of testing positive on any given test is low. Most months...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    I watched that video and I think I see what's going on. There's a lot of that in the science communication world. Basically, it's an alliance of science and a very "conservative" type of "alternative" health, where researchers come out and act as if they are starting "a revolution" when in fact...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I think what we're running up against is a sort of "Catch 22" where most people don't try FMT because it's not readily available, and so then you don't have huge groups of people with success stories to tell who would sign petitions like this. Add to that the fact that even among those who DO...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    First the good: I REALLY appreciate the attempt to include a broader range of bacterial diversity (both genetic and functional) than the vast majority of other probiotics. We have one sugar fermenting lactic acid bacterium (Enterococcus), one "secondary fermenter" that utilizes the lactate...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Who is most important for us to contact at this point?
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    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    “There are microbes along the entire intestinal tract, and we just study predominately the last third of it (the colon),” DeLeon said. I've been saying this for years as well! That almost the entire research on the gut is focused on the large intestine, which in turn means largely on just two...
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    Early development In utero human intestine contains maternally derived bacterial metabolites (May 2025, n=21)

    From the very first sentence of the Methods section: "Placental and fetal samples were obtained from the University of Pittsburgh Biospecimen Core from electively terminated products of conception (14–23 weeks of gestation)" So indigo34 was correct--these were aborted fetuses.
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    Oral Swapping spit with your spouse may spread anxiety and depression (Apr 2025, 536 couples) Oral Microbiota Transmission Partially Mediates Depression and Anxiety in Newlywed Couples

    Interesting--I'm not too surprised.
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    Gezonde Darmflora Improvements to sleep, IBS, and weight from donor DF3 from Gezonde Darmflora

    Just so everyone here knows who might be thinking of trying her, DF3 is unfortunately no longer available How did you confirm a Lyme relapse? Did you have a recurrence of arthritis, a bull's eye rash, or some other specific Lyme symptom? In my experience, not only is it difficult to tell many...
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    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    Recently posted by someone in another FMT group. https://www.cell.com/cell/abstract/S0092-8674(25)00564-1 "Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    MANY bacteria, including many probiotic strains, produce histamine. This is well studied--there are apparently probiotics that are supposed to contain low-histamine strains.
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    Enhancing Antifreeze in stool/FMT capsules, glycerol vs maltodextrin, -80 (medical freezer) vs -20 (home freezer)

    I'm wondering what were the alternatives/comparison groups.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Responded here: https://forum.humanmicrobiome.info/threads/thoughts-on-humanmicrobes-donor-problem.163/post-2528
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    Donors Thoughts on HumanMicrobes donor problem

    They may not look at stool type like you do, but they have looked at other things, in particular: -Use of proton pump inhibitors prior to upper route (Answer... it seems it's not very important, I think they even don't do it anymore) -Use of vancomycin pretreatment (Answer: improves the success...
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    Procedure Getting blood and stool testing for an FMT donor

    For those who found themselves private donors, when it came time to get the bloodwork done, how did you do it? Did you give the donor the list of tests and have him/her contact his/her doctor to get them ordered, then reimburse? or did you find a doctor online who would order them for the donor...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Arizona State University has been doing FMT studies in kids with ASD for years. They found benefits. It hasn't translated yet into the treatment being widely available for ASD kids though.
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    FMT VA trial using the University of Minnesota's donors, finds no reduction in C diff recurrence after FMT (Sep 2024, n=153, UMN) A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection

    When I got my OpenBiome FMT, it was at most 48 hours prior to the procedure that I was instructed to stop taking vancomycin. It might have even been only 24 hours, and yet however long it was, it still perfectly did its job breaking the cycle of C. diff recurrences. It also did a lot of other...
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    State of microbiome-based therapies 5-10 years from now?

    If your experience contradicts this, then that again shows how poorly your reports convey what various treatments did for you, because as I understand them by reading, nothing in your descriptions in any way goes against what I said above. First there was the fact that the four donors who...
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    Comparative study of H pylori and Streptococcus anginosus on genomes based

    You might be better off asking in a computational biology forum like Biostars or r/bioinformatics, but what are you looking to do? Are you looking to take genomes of new strains that lack gene annotations and find genes in there? or is knowing the pathways from the genomes of reference strains...
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    State of microbiome-based therapies 5-10 years from now?

    The microbiome DOES have a profound effect on mental, in addition to just physical health. However, not in the way you imagine if you are seriously asking yourself questions like this. I thought of this before my very first FMT (and before some other interventions before that)--I am on the...
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    Blog The FDA and FMT regulation, part 2. (Jul 2024, HumanMicrobes.org) I met with the FDA. Here's what I shared with them, and their response.

    The thing is, their hands are tied as well (in the US). Doctors and other medical professionals who promote FMT for conditions other than C. diff risk disciplinary action up to eventually losing their medical licenses if they persist. By "promote" here I mean not just to state they believe in...
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    Early development Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort (Mar 2025, n=36)

    It's interesting that they only found bacteria negatively associated with normal development, and none positively associated. However they found increased diversity associated with normal development, which suggests that maybe normal development is promoted by a large variety of different...
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    Procedure DIY FMT Beginner's Questions

    Just to add something to 2: In my case, improvement continues for at least a month if not longer after FMT. After my most successful FMT, there were a number of clear immediate (same day/week, this was an endoscopy procedure) changes, but the most dramatic changes happened right around the six...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    I do see that you already cite this 2018 in your probiotic page--good for you! But do you mean you had already concluded this BEFORE 2018? If so, was it based on an even earlier study, or simply on your own experience and testimonials from other patients? If the latter, then you do deserve...
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    FMT FDA sent MG Infusions a warning letter; website is down. (Mar 2025)

    "I see that they do send warning letters to people outside the US." What force does this have? Does this mean that if the foreign seller doesn't comply, that anything coming into the US from such a seller will be seized and destroyed? In any case, this obviously confirms the FDA is back up and...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Also, did you see the reference about probiotics cited in that article (Ref #2)? I only noticed it just now, but it's informative. The conclusion of that one was that probiotics actually delay recovery of the gut microbiome after antibiotics, relative to taking nothing except the antibiotics...
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    Antibiotics The researchers on a quest to protect the gut from antibiotics. The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects (Feb 2025, Florey Biosciences)

    Too late for us whose guts are already messed up, but hopefully this will be around for patients in the future! It's an engineered strain of yeast that destroys antibiotics in the gut before they have a chance to deplete the intestinal microbiome.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    So basically he is concerned with health care, or at least claims to be, but only so far as to help people afford conventional treatments like pharmaceuticals? Rather than accuse people of being frauds, your message should be that there is an effective treatment that is banned by the...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is that relevant to FMT? I'm assuming this was a hearing relating to health policy? If so, getting the serious attention of anyone in those hearings could be a win, even if it's only a few people. If this hearing was on an unrelated topic, then obviously it wasn't a good place to bring up...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    How is the campaigning in DC going?
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    The group is just called "Fecal Microbiota Transplantation".

    The group is just called "Fecal Microbiota Transplantation".
    • SFBayFMT5
    • Profile post comment
  32. S

    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Sure EvaJak. These FMTs were the latest in a series that I started last May, so you may want to read my previous review of HM (in which I also compare and contrast that with OpenBiome). But briefly, this whole thing started with a sort of stretching pain in my middle back and a visibly swollen...
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Firstly, how do you know it's even the same woman we are talking about? Secondly, much of my interaction with her was in private messages, it was not public. Not to say that what she said publicly was in any way lacking in transparency either mind you--just that if she didn't spell everything...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    That site has "scam" written all over it! Lots of very good sounding but completely vague verbiage and no actual work they are doing.
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    It was the man, not the woman, who was evasive. The woman was very forthcoming about exactly how she had done her FMTs and what her experience was. She however ONLY used DF3, which was the donor who made me worse. The man had used both. This third study is about frozen FMT vs. FMT that has...
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    Gezonde Darmflora Review of two Gezonde Darmflora donors--one good and one bad. DF3 and DF7.

    Firstly--so Gezonde Darmflora (who I will call GD from now on) went through a period earlier this winter of not accepting orders from the US due to customs issues--thankfully neither of my orders had this problem although other orders in the same time frame did. Now they have solved this problem...
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    Outcomes Body odor changes after FMT?

    -do you get the same body odor as your donor after a lot of fmts? or is it more of a temporary effect that's gone as soon as you finish the fmts? I have not smelled the body odor of any donors as I do not know any of them personally. I also haven't noticed major shifts in my BODY odor after FMT...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I just wrote to Senator Cassidy last night
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    Just last night I posted a very recent (in fact, not yet formally published in a journal) paper...

    Just last night I posted a very recent (in fact, not yet formally published in a journal) paper in the "Microbiome studies, news, media" section that you might really like to read. You ask a lot of questions about the microbiome and how it functions biochemically, that's what this paper is all...
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    Question GutID Microbiome Test

    In what way were you not impressed with Viome's results? Did they indicate your gut was "normal" despite you feeling very poor? That's how Thryve (now Ombre) was for me. I read about GutID and it seems the chief advantage they claim is that they identify bacteria down to the strain level...
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