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  1. Michael Harrop

    Antibiotics Repeated antibiotic use before age 2 is associated with a higher risk for asthma, food allergies, and hay fever later in life (Apr 2025, n=1m) Early childhood antibiotics and chronic pediatric conditions: a retrospective cohort study

    https://www.rutgers.edu/news/frequent-use-antibiotics-infants-and-young-children-may-increase-risk-asthma-allergies-and https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiaf191/8114163 For those other conditions, it may be that the parents' (and even grandparents')...
  2. Michael Harrop

    Probiotics Sauerkraut helps maintain the integrity of intestinal cells, while raw cabbage and brine did not (Apr 2025, in vitro) The fermented cabbage metabolome and its protection against cytokine-induced intestinal barrier disruption of Caco-2 monolayers

    https://www.eurekalert.org/news-releases/1080484 https://journals.asm.org/doi/10.1128/aem.02234-24 It's not even done in mice, so it's more of a "Plausible mechanism whereby fermented foods might be beneficial".
  3. Michael Harrop

    Other Gut microbes release cancer-fighting bile acids that block hormone signals (Apr 2025) Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity

    https://medicalxpress.com/news/2025-04-gut-microbes-cancer-bile-acids.html https://www.cell.com/cell/abstract/S0092-8674(25)00256-9
  4. Michael Harrop

    Causation The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study (Apr 2025)

    https://www.nature.com/articles/s41598-025-97722-9 I experience this myself. My eyesight improves or gets worse along with my gut microbiome status.
  5. Michael Harrop

    Other An imbalance of gut metabolites in children with autism disrupts neurotransmitter production, influencing behavioral symptoms (Apr 2025, n=84) Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology

    https://www.eurekalert.org/news-releases/1080059 https://www.nature.com/articles/s41467-025-58459-1
  6. Michael Harrop

    FMT Multi-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension (May 2025, n=62) "FMT from patients induced PAH phenotypes in recipient rats. FMT from normal rats to MCT-PAH rats significantly ameliorated PAH symptoms"

    https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00130-6/fulltext
  7. Michael Harrop

    Other Big data from world's largest citizen science microbiome project reveal how diet, antibiotics and mental health status influence your gut (May 2018) American Gut: an Open Platform for Citizen Science Microbiome Research

    https://www.sciencedaily.com/releases/2018/05/180515092931.htm https://journals.asm.org/doi/10.1128/msystems.00031-18
  8. Michael Harrop

    Oral Causal relationship between gut microbiota and dental caries: a two-sample mendelian randomization study (Apr 2025)

    https://www.nature.com/articles/s41405-025-00328-6
  9. Michael Harrop

    Other Starch-based microplastics could cause health risks in mice (Apr 2025) Long-Term Exposure to Environmentally Realistic Doses of Starch-Based Microplastics Suggests Widespread Health Effects

    https://www.sciencedaily.com/releases/2025/04/250409114956.htm https://pubs.acs.org/doi/10.1021/acs.jafc.4c10855 It's closed access so I can't see who funded this. Was it funded by the oil industry or are we just fucked no matter what we do?
  10. Michael Harrop

    Other Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice (Apr 2025)

    https://www.sciencedirect.com/science/article/abs/pii/S0304389425011409
  11. Michael Harrop

    Oral Oral Bacteria May Help Detect Autism with 81% Accuracy (Nov 2024, n=25) Alterations of oral microbiota in young children with autism: Unraveling potential biomarkers for early detection

    https://neurosciencenews.com/autism-oral-microbiome-28569/ https://medicalxpress.com/news/2025-04-disciplinary-reveals-oral-microbiota-screen.html https://www.sciencedirect.com/science/article/abs/pii/S0300571224006560
  12. Michael Harrop

    Causation The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis (Sep 2024)

    https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01132-6/abstract The fact that the analysis is on the genus level seems to be the biggest caveat.
  13. Michael Harrop

    FMT Assessment of Dientamoeba fragilis interhuman transmission by fecal microbiota transplantation (Apr 2025, 86 donors, 124 patients) "No evidence of transmission. Should no longer be an exclusion criterion for donor screening"

    https://www.sciencedirect.com/science/article/abs/pii/S0924857925000615
  14. Michael Harrop

    Other Artificial sweetener saccharin not only kills drug-resistant bacteria but also makes existing antibiotics more effective (Apr 2025) Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics

    https://phys.org/news/2025-04-artificial-sweetener-power-antibiotic-resistance.html https://www.embopress.org/doi/full/10.1038/s44321-025-00219-1
  15. Michael Harrop

    Testing Purdue researchers show common bacterial assay is unreliable (Jan 2025) Propidium Monoazide is Unreliable for Quantitative Live–Dead Molecular Assays

    https://ag.purdue.edu/news/2025/04/purdue-researchers-show-common-bacterial-assay-is-unreliable.html?image https://pubs.acs.org/doi/full/10.1021/acs.analchem.4c05593
  16. Michael Harrop

    Causation Causal relationship between gut microbiota, metabolites, and short stature: a Mendelian randomization study (Apr 2025)

    https://www.nature.com/articles/s41390-025-03985-3
  17. Michael Harrop

    Aging Aging microbiome produces fewer vital substances (Mar 2025) Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice

    https://medicalxpress.com/news/2025-04-metabolic-reveals-aging-microbiome-vital.html https://www.nature.com/articles/s41564-025-01959-z
  18. Michael Harrop

    Probiotics Metagenomic evaluation, antimicrobial activities, and immune stimulation of probiotics from dietary supplements and dairy products (Apr 2025) "only 37% of the predominant microorganisms identified by metagenomics were accurately listed on product labels"

    https://www.nature.com/articles/s41598-025-95664-w This conflicts with another similar recent study: Genomic interrogation of commercial infant probiotic products for label accuracy (Jan 2025) "Most bacterial species in commercial infant probiotic products are accurately represented on labels"
  19. Michael Harrop

    Probiotics Novel probiotic strain proves more effective for treating Giardiasis, a common intestinal infection (Mar 2025) Isolation of derivatives from the food-grade probiotic Lactobacillus johnsonii CNCM I-4884 with enhanced anti-Giardia activity

    https://medicalxpress.com/news/2025-04-probiotic-strain-effective-common-intestinal.html?deviceType=desktop https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2474149
  20. Michael Harrop

    FMT Patient–donor similarity and donor-derived species contribute to the outcome of faecal microbiota transplantation for ulcerative colitis (Apr 2025, n=97)

    https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjaf054/8102791 Looks interesting, but it's closed access so I can't analyze it. A group of researchers from Japan.
  21. Michael Harrop

    Probiotics A double blinded randomized placebo trial of Bifidobacterium animalis subsp. lactis BLa80 on sleep quality and gut microbiota in healthy adults (Apr 2025) "a significant reduction in the PSQI total score compared to placebo"

    https://www.nature.com/articles/s41598-025-95208-2
  22. Michael Harrop

    Vaccines Early life antibiotics weaken babies’ immune responses to vaccines (Apr 2025, n=191) Bifidobacteria support optimal infant vaccine responses

    https://www.nature.com/articles/s41586-025-08796-4 https://cosmosmagazine.com/health/body-and-mind/baby-antibiotics-vaccines/
  23. Michael Harrop

    FMT Mice given FMT from elite cyclists and soccer players had increased energy stores (Mar 2025) Atypical gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice

    https://www.sciencenews.org/article/elite-athletes-poop-key-to-metabolism https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00219-0
  24. Michael Harrop

    Probiotics Probiotic may improve sleep quality (Dec 2024, n=60) Regulation of Sleep and Circadian Rhythms by S-Adenosylmethionine-Producing Probiotics

    https://www.eurekalert.org/news-releases/1078283 https://www.sciencedirect.com/science/article/pii/S2095809924007422
  25. Michael Harrop

    Probiotics Best practices for designing better clinical trials of probiotics and prebiotics (Oct 2024) Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome

    https://www.gutmicrobiotaforhealth.com/best-practices-for-designing-better-clinical-trials-of-probiotics-and-prebiotics/ https://www.nature.com/articles/s41564-024-01831-6
  26. Michael Harrop

    Vagina Intravaginal probiotics reduce the recurrence of asymptomatic bacterial vaginosis in Chinese women (Mar 2025, n=716) "Probiotics emerge as a superior therapeutic option for aBV compared to metronidazole due to their comparable cure rates, lower recurrence rates, and minimal side effects"

    https://www.nature.com/articles/s41598-025-92843-7
  27. Michael Harrop

    FMT Education and Advocacy in DC: The Peggy Lillis Foundation's (PLF) National C. Diff Summit and Lobby Day (Mar 31, 2025)

    https://cdiff.org/event/2025-national-c-diff-summit/ https://www.contagionlive.com/view/education-and-advocacy-in-dc-the-plf-c-diff-summit-and-lobby-day Sponsored by Nestle. Near the bottom of their website, they list a whole bunch of corporate sponsors -- lots of big pharma companies...
  28. Michael Harrop

    FMT FDA sent MG Infusions a warning letter; website is down. (Mar 2025)

    https://www.einnews.com/pr_news/795004875/mg-infusions-696890-03-10-2025 https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/mg-infusions-696890-03102025 Looks very similar to the letter they sent me a year ago. Strange that it took them a full...
  29. Michael Harrop

    Vaccines The relationship between gut microbiota, immunoglobulin A, and vaccine efficacy (Feb 2025) Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

    https://medicalxpress.com/news/2025-03-relationship-gut-microbiota-immunoglobulin-vaccine.html https://www.science.org/doi/10.1126/sciadv.ado9455
  30. Michael Harrop

    Early development Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort (Mar 2025, n=36)

    https://www.nature.com/articles/s41598-024-81774-4
  31. Michael Harrop

    Other Bacterial slime on microplastics help breed antibiotic-resistant superbugs (Mar 2025) Effects of microplastic concentration, composition, and size on Escherichia coli biofilm-associated antimicrobial resistance

    https://www.wlfi.com/news/bacterial-slime-on-microplastics-help-breed-antibiotic-resistant-superbugs-study-says/article_24b9297b-5fb2-568e-8d28-c1cae12fd964.html https://journals.asm.org/doi/10.1128/aem.02282-24
  32. Michael Harrop

    Other Gut bacteria heal the colon (Mar 2025) Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

    https://www.eurekalert.org/news-releases/1076283 https://www.embopress.org/doi/full/10.1038/s44321-025-00202-w
  33. Michael Harrop

    FMT Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model (Feb 2025) "gut microbiota may be a mediator of the protective effect of APOEe2"

    https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1539067/full
  34. Michael Harrop

    Antibiotics Gut Microbe Composition During Infancy May Protect Against Diabetes in Later Life (Mar 2025, mice) Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development

    https://www.genengnews.com/topics/translational-medicine/gut-microbe-composition-during-infancy-may-protect-against-diabetes-in-later-life/ https://www.colorado.edu/today/2025/03/19/gut-check-how-healthy-microbes-infancy-reduce-diabetes-risk Scientists Warn: Popular Infant Medicine Could Trigger...
  35. Michael Harrop

    FMT Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn’s disease: a prospective trial (Mar 2025, n=49) "remission rates did not differ between the two groups"

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05832-1
  36. Michael Harrop

    Early development Longer breastfeeding linked to blood-pressure lowering effects of certain infant gut bacteria (Feb 2025, n=526) Infant Gut Microbiota and Childhood Blood Pressure: Prospective Associations and the Modifying Role of Breastfeeding

    https://www.nih.gov/news-events/news-releases/longer-breastfeeding-linked-blood-pressure-lowering-effects-certain-infant-gut-bacteria https://www.ahajournals.org/doi/10.1161/JAHA.124.037447
  37. Michael Harrop

    FMT A synthetic microbiome therapy suppresses C. diff infection without antibiotics (Mar 2025) A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance

    https://medicalxpress.com/news/2025-02-synthetic-microbiome-therapy-suppresses-bacterial.html https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00055-1
  38. Michael Harrop

    Diet Gut Microbes Feed On More Than Fiber. Gut microbes produce many substances that our body needs but cannot produce itself, including short-chain fatty acids (Mar 2025) Metformin-regulated glucose flux from the circulation to the intestinal lumen

    https://www.technologynetworks.com/immunology/news/study-reveals-gut-microbes-feed-on-more-than-fiber-396735 https://www.nature.com/articles/s43856-025-00755-4
  39. Michael Harrop

    FMT FMT enhances wound healing in diabetic mice (Feb 2025) Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A–mTOR–HIF1α signaling axis

    https://journals.asm.org/doi/10.1128/aem.02019-24
  40. Michael Harrop

    FMT Effects of gastrointestinal symptoms on the efficacy of washed microbiota transplantation in patients with autism (Feb 2025, n=129) "Efficacy was enhanced in patients with pre-existing GI symptoms, and those receiving increased treatment courses. Alleviated ASD, GI symptoms, and sleep disturbances"

    https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1528167/full
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