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  1. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I definitely seem to react very strongly to garlic and/or oregano. I wonder if finding out what garlic and oregano do could yield a clue as to what the story is with my gut. I'm referring to supplements here; I'm not talking about eating the actual herbs.
  2. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    This is interesting, right? https://royalsocietypublishing.org/doi/full/10.1098/rstb.2017.0286 Early life is a critical period for gut colonization [51], the establishment of the HPA axis, as well as neurodevelopment ([4] and references therein), and growing evidence suggests these systems...
  3. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: I got a great reaction from taking garlic and oregano. There's no way to guess why those two things might be helping me, though, right? Those two things combat pathogenic bacteria, but they do various things. 2: Is it worth learning about "nitrogen metabolism"? What are the other major...
  4. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Is there any literature on the idea that taking too high a dose of probiotics could produce SIBO? I don't know what is supposed to cause SIBO or whether there are even any leading hypotheses about what causes it. Why isn't "Turicibacter sanguinis" available as a probiotic? Just curious...
  5. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I'd never heard of this product: https://pmc.ncbi.nlm.nih.gov/articles/PMC5138452/ From the presented overview of Symbioflor E. coli research, which to the knowledge of the author covers all available peer-reviewed literature on this product, it is obvious that the research conducted is...
  6. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Is it possible that any of the bacteria types included in this ( https://aor.ca/product/probiotic-3 ) product are actually unhelpful or even harmful? One tends to think that they wouldn't be selling X unless X were at least safe and hopefully effective too. From the above link, see this...
  7. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Is there any literature on the combination of antihistamines (H1, H2, and both H1 and H2) and probiotics? Is there a potential ambiguity whereby you think you have a gut-biota problem but actually you have an immune-system problem? For example, someone might take an anti-inflammatory drug (like...
  8. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I haven't been on this forum for a long time. See below some questions. 1: What are the odds that it will turn out that the gut biota are not as impactful as many thought? To what extent is there unwarranted "hype" around gut biota? See here, for example...
  9. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I wouldn't be surprised if addressing gut-biota problems fixed any psychiatric condition. Of course, a big question is whether there will be any clinical trials that will take a gut-biota treatment (in this case, for bipolar) from anecdote to something more than anecdote. Do you know any trials...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Doesn't seem like it's possible to buy an L-DOPA supplement. You can only get the one that isn't "earmarked" for production of DA and NE, right?
  11. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: I took some 5-HTP last night and it made a huge (!!!) difference. I really hope that this quite miraculous improvement doesn't go away. 2: When was the last time you took some 5-HTP? Baffling to me why it stopped working for you; hope you can get the effect back. 3: What can one say about...
  12. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Do you guys know a lot about butyrate and butyrate supplementation? See this excellent paper: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.893567/full. The paper says interesting things about butyrate, including the following: 2: I took some butyrate pills...
  13. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: I get a huge reaction from melatonin. That's why I'm interested in agomelatine, which apparently has a superior melatonin-receptor effect to melatonin's, though I can't remember what exactly the advantage is supposed to be. 2: Melatonin is a fascinating thing...see this paper here...
  14. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks for the excellent points. I appreciate it. 1: If you don't mind me asking, what are your credentials? You seem to have professional knowledge. 2: What do you think about Pendulum's products? Some of their products seem to be redundant. I think that the "Metabolic Daily" one contains...
  15. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you guys think about the cocktail that is mentioned below? And is that cocktail at all close to being available to consumers? https://www.mdpi.com/2076-2607/12/8/1627
  16. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks. I assume that only trial and error can tell you which of the below is the best value for the money? They're all different prices on a per-capsule basis. https://www.amazon.ca/Boulardii-Billion-Diarrhea-Relief-Capsules/dp/B00CORN7PW...
  17. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Regarding treatment of dysbiosis, what are the implications of the bold part below? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300896/ How often do people use this type of probiotic? I hadn't heard of it...
  18. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I sometimes have these insane (absolutely INSANE) "collapses". I wonder whether phages might cause these collapses ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764184/ ). 1: Phages might be responsible for a lot of people's dysbiosis, right? 2: But aren't people kind of screwed in the...
  19. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Is there any science (or speculation) that might explain the below scenario? --someone is taking a couple basic probiotics (Align and Culturelle) and doing extremely well thanks to those probiotics --the person suddenly undergoes a "collapse" where they lose all the wonderful health...
  20. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: What do you guys think about this? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389721/ 2: And this? 3: If a given probiotic only benefits you by creating a certain SCFA, is just supplementing that SCFA (by taking a "postbiotic") a superior option?
  21. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Anyone here heard of combining apple-cider vinegar with probiotics? Not sure if there's any experience showing that that combo can be useful. Or any science that would point toward a potential synergy there. 2: What explains the seemingly weird precariousness regarding the fact that a human...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I wonder about this: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.993451/full Some probiotics are mentioned below that I haven't heard much about. I'd love to try some of these less-known probiotics eventually if the better-known ones aren't sufficient...
  23. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I posted the below: I got this response so far: I wonder what limitations the studies linked above (by the PhD guy) have. And to what extent can those studies' conclusions really be generalized? People are different, right? I really hope that I can change my gut-biota situation. Otherwise...
  24. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: My curiosity about "muddying the waters" was that if you resist the temptation to add another probiotic to the ones you''re taking then you'll get better information than if you rush ahead. Do you see the conundrum? Adding new probiotics might improve things but also "muddies the waters" in...
  25. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: If there's a microbe that "eats" quercetin and you pump quercetin in your body, that's a great thing. But do you know any actual papers on the notion that pumping nutrients into your gut will end up expanding the population of whichever microbes eat that nutrient? Maybe there aren't any...
  26. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Have you tried this and is it worth trying? https://seed.com/daily-synbiotic 1: Have you tried a VERY high dose of bromelain? And of quercetin? And of both of the two? 2: Why did the below work so well for you but then stop working? I don't get it. Have you asked scientists why something...
  27. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Just to reiterate something we talked about previously, we can't possibly know how much impact on the human brain and body the loss of various bacterial strains has had, correct? 2: What is the "ceiling" in terms of the maximum impact that the loss of a single strain could have on the human...
  28. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Doesn't the below information provide some very clear ideas about what to try? And yet doctors won't be able to recommend ideas to patients on the basis of the below information, right? Large-scale clinical trials are needed before doctors can recommend things, correct...
  29. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I just tried this today for the first time and so far it's been a smashing success: https://en.wikipedia.org/wiki/Quercetin. I want to try bromelain too. Do you know about bromelain and quercetin? Have you tried them yourself?
  30. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I apologize if I asked this previously, but why can't SCFAs just be supplemented directly? Why can't one just take pills that contain SCFAs? I know that that might not be as healthy as producing SCFAs the natural way in your colon, but nevertheless I wonder about whether direct supplementation...
  31. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I just wanted to know if you'd find anything interesting in those papers. Have you tried pectin? What are your favorite prebiotics? I found this interesting: https://www.sciencedirect.com/science/article/pii/S0268005X22004787
  32. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you make of this paper? https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.578386/full Hosting millions of microorganisms, the digestive tract is the primary and most important part of bacterial colonization. On one side, in cases of opportunistic invasion...
  33. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Where was the info on disruption, sorry? My apologies about not reading information; my mental health is often really bad. 2: Was your previous point just that the gastric and intestinal microbiomes are connected? They're still talked about as distinct things in the literature, right? 3: H...
  34. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Thanks. I took a probiotic pill a couple days in a row. When I took the probiotic yesterday, it messed me up quite a bit. Is it normal for probiotics to make things worse at first? I can imagine that introducing new microbiota to your GI system could be disruptive.
  35. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What information/papers do you know of regarding the connection between gastric microbiota and intestinal microbiota? I thought they were separate. See here a paper that I just found randomly: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006573 Drivers of...
  36. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1: Do you know any papers on gastric dysbiosis? And on how important gastric dysbiosis can be? 2: Do you know any information (or papers) on how one can find out if one has gastric dysbiosis? And on what treatments are possible? I know that this is a somewhat random (maybe?) question, but do...
  37. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Have you tried everything that I mentioned in combination? I wonder whether doing so can make all the difference; if you try things individually then the effect might not be significant at all.
  38. G

    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Michael, what's been your response to this combination: --lots of apple-cider vinegar (this is the main agent) --Pepto Bismol (a little bit) --NAC (the supplement, I mean...it has impacts on microbiota...it has impacts on various things) --the following cocktail of extracts: ginger...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I had an extremely good response to this: https://www.jamiesonvitamins.com/products/probiotic-ultra-strength-60-billion Lactobacillus paracasei (HA-196) 21.6 CFU Lactobacillus paracasei (R0215) 21.3 CFU Bifidobacterium breve (HA-129) 8.7 CFU Lactobacillus plantarum (R1012) 4.2 CFU...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    What do you think of this? https://www.annualreviews.org/content/journals/10.1146/annurev-med-042320-014032 The effects of enteric microbial manipulations in controlled clinical trials in patients with depression and/or IBS have been evaluated with probiotics, antibiotics, and the low-FODMAP...
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