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  1. Michael Harrop

    Article The Poop Broker. Michael Harrop started a booming underground market for human feces. But something smells off about his product. (May 2024)

    https://slate.com/life/2024/05/fecal-transplant-fmt-c-diff-microbiome-poop-black-market.html Kind of an odd article. Amusing, seemingly agenda-driven, occasionally deceptive, but not all bad. I'm curious what impact this article will have. Will it be better or worse than the "complete silence"...
  2. Michael Harrop

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    There appears to be an impact on lifespan, but not that much research on it yet https://humanmicrobiome.info/aging/. Most of the research looks focused on healthspan.
  3. Michael Harrop

    Antibiotics Commonly used antibiotic brings more complications, death in the sickest patients (May 2024, n=7569) Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime

    https://www.eurekalert.org/news-releases/1044459 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2818278
  4. Michael Harrop

    FMT Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice (Apr 2024)

    https://www.aginganddisease.org/EN/10.14336/AD.2024.0321
  5. Michael Harrop

    Vaccines Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? (May 2024, NYT) All vaccines have at least occasional side effects. But people who say they were injured by Covid vaccines believe their cases have been ignored.

    Were either of you vaccinated? Either way, FMT is likely the solution: The gut microbiome, COVID-19, and long COVID [collection of studies] https://humanmicrobiome.info/brain/
  6. Michael Harrop

    Other Removing gut bacteria's potential 'safe house' (appendix) may lower risk of colorectal cancer subtype (May 2024, n=139,406) Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status

    https://medicalxpress.com/news/2024-05-gut-bacteria-potential-safe-house.html https://journals.lww.com/annalsofsurgery/abstract/9900/appendectomy_and_long_term_colorectal_cancer.870.aspx The appendix, once dismissed as an unnecessary human organ, has more recently been shown to play a role in...
  7. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    What is the basis for that notion? Additionally, poor engraftment can be due to a low-quality donor. And this thread is relevant as well, in regards to engraftment and FMT outcomes: https://forum.humanmicrobiome.info/threads/fmt-engraftment.372/
  8. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    What's more is that I've done the work for them -- screening a million donors. They have no excuse anymore, yet they keep on doing it. Another group just announced an FMT clinical trial on Twitter. I asked about donor quality and selection and got no response.
  9. Michael Harrop

    FMT The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch) (May 2024, n=30)

    https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjae066/7665392 Yet another FMT trial harming patients and extending the unavailability of FMT due to using low-quality donors.
  10. Michael Harrop

    Vaccines Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? (May 2024, NYT) All vaccines have at least occasional side effects. But people who say they were injured by Covid vaccines believe their cases have been ignored.

    https://www.nytimes.com/2024/05/03/health/covid-vaccines-side-effects.html I've seen this same attitude and dismissal when the harms of antibiotics are brought up in laypeople communities.
  11. Michael Harrop

    Prebiotics Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model (Mar 2024) Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation

    https://medicalxpress.com/news/2024-05-common-fiber-trigger-bowel-inflammation.html https://rupress.org/jem/article-abstract/221/5/e20232148/276641/Dietary-fiber-is-a-critical-determinant-of Another example of possible detriments from prebiotics https://humanmicrobiome.info/prebiotics/#detriments.
  12. Michael Harrop

    Oral Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes (May 2024)

    https://www.nature.com/articles/s41564-024-01680-3 A useful addition to the "Does the oral microbiome colonize the gut?" question.
  13. Michael Harrop

    Early development Father's gut microbes affect the next generation (May 2024, mice) Paternal microbiome perturbations impact offspring fitness

    https://medicalxpress.com/news/2024-05-father-gut-microbes-affect-generation.html https://www.nature.com/articles/s41586-024-07336-w
  14. Michael Harrop

    Article Multicellular Bacteria Evolve Defenses that Resemble the Immune System (Apr 2024)

    https://www.the-scientist.com/multicellular-bacteria-evolve-defenses-that-resemble-the-immune-system-71807
  15. Michael Harrop

    Antibiotics Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk (Apr 2024)

    https://www.jacionline.org/article/S0091-6749(24)00409-3/fulltext An increased number of antibiotic courses corresponded to a dose-response-like increased risk https://www.medpagetoday.com/dermatology/atopy/109868
  16. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    You can email me for it. I'm choosing not to advertise it publicly for now.
  17. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    I've had a good amount of them apply, and I've offered them referral rewards to recruit their buddies, but I have no way to target this/any group. Yes, I discussed that in the most recent blogs. No, just "regular" people.
  18. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    Yep. Other people have suggested similar things. FMT needs to be widely advertised as a way that these one in a million lucky people can be the source of a cure for millions/billions of people, in order to motivate them to sign up. But I have no way to do that. It either requires a massively...
  19. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    Yes. Up to you. If a bunch of people want to debate activating a certain donor you can pair up to split the testing costs. This forum can be used for that but so far no one has. Some people have used untested donors. Covered here https://humanmicrobiome.info/fmt/. If anyone decides on a donor...
  20. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    They were people I found prior to HM, and yes, they wouldn't do more than 1 each. I was referring to both. Those safety tests are extremely basic and can in no way be relied upon for safety. Stool sources that tout their rigorous testing as proof of safety should be avoided. Most would fail...
  21. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    Yes, I just interviewed one 2 days ago, and I'm interviewing another one today. Yes, because I haven't been able to find a single donor with a similar stool type to the 3 most effective donors I previously used. Any place like that is a roll of the dice. Some people improve, others get much...
  22. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    I don't think so, and I don't think the skin color comparison is applicable. To be more specific, it was their endurance when hunting, and them sleeping in the cold on the hard ground with no shirt or blanket. Both of these are gut microbiome related. Donor-matching is covered in various...
  23. Michael Harrop

    Blog High-quality stool donors are more rare than one in a million? AI, funding, and potential. (Mar 2024, HumanMicrobes.org)

    Some of those claims need citations. It is more so that damaged gut microbiomes are the norm [1][2], even in the top echelon of athletes. My comment here is also relevant.
  24. Michael Harrop

    Antibiotics Large study finds antibiotics aren't effective for most lower tract respiratory infections (Apr 2024, n=718) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection

    Would a study like this immediately change the way you prescribe antibiotics for this particular use case of lower tract respiratory infections? Or do you wait for some other guidelines to get updated?
  25. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    Someone who used HM's donors also did FMT from the Hadza. He got short-term benefits but detriments in the long term due to pathogens he picked up from them. But he described some of their traits as "super-human". The Hadza are closer to what an "average human" should be. The "average human" in...
  26. Michael Harrop

    FMT Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation (Apr 2024)

    I also had chronic sciatica pain (and arthritis pain) cured via FMT. Definitely would. https://humanmicrobiome.info/brain/
  27. Michael Harrop

    Vaccines Universal vaccine may be effective against any variant of any virus (Apr 2024) Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells

    https://www.earth.com/news/universal-vaccine-may-be-effective-against-any-variant-of-any-virus/ https://medicalxpress.com/news/2024-04-vaccine-strategy-line-endless-boosters.html https://www.pnas.org/doi/10.1073/pnas.2321170121
  28. Michael Harrop

    Antibiotics Large study finds antibiotics aren't effective for most lower tract respiratory infections (Apr 2024, n=718) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection

    https://medicalxpress.com/news/2024-04-large-antibiotics-effective-tract-respiratory.html https://link.springer.com/article/10.1007/s11606-024-08758-y And they STILL largely ignore the effects of collateral damage of antibiotics https://humanmicrobiome.info/antibiotics/.
  29. Michael Harrop

    Blog Half a million stool-donor applicants... (2023, HumanMicrobes.org)

    I'm a patient, not a doctor. No personal trainer is required for the HumanMicrobes.org physical assessment, but people can include whatever extras they like.
  30. Michael Harrop

    The gut microbiome, COVID-19, and long COVID [collection of studies]

    I saw news about "Chairman Bernie Sanders Releases Long COVID Moonshot Legislative Proposal", and I wanted to make a post listing the research I've seen on this. From what I see in their proposal, they're allocating 1 billion dollars into general research. I find this very frustrating given...
  31. Michael Harrop

    FMT Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice (Apr 2024)

    It’s not an FMT forum. Anything microbiome & health-related is fine. FMT is simply the most promising, complete, and studied intervention.
  32. Michael Harrop

    Other Infections after surgery are more likely due to bacteria already on your skin than from microbes in the hospital. Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery (Apr 2024, n=204)

    https://theconversation.com/infections-after-surgery-are-more-likely-due-to-bacteria-already-on-your-skin-than-from-microbes-in-the-hospital-new-research-227435 https://www.science.org/doi/10.1126/scitranslmed.adk8222
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