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  1. Michael Harrop

    Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    I posted about this a few years ago elsewhere and I'm copying all the info here for easy discussion. "While fecal microbiota is partially normalized by extended co-housing, mucosal communities associated with the proximal colon and terminal ileum remain stable and distinct". Comparison of...
  2. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    Katie McCaskey wrote to me on Mastodon: I took a look at the link and I'm working on writing up something about FMT/Human Microbes to submit, but I see "What are specific steps the federal government can take to implement your solution?". I'm doubtful that the feds are the best option to...
  3. Michael Harrop

    FMT, donor-matching, screening for specific microbes, and pre-treatment/eradication. "Killing things off" vs suppression & ecosystem restoration.

    Someone wrote to me about this. It's always better to discuss publicly so others can learn and weigh in. See https://humanmicrobiome.info/testing. I do not think this is a valid approach. Current testing is way too limited, and I'll write more below. This is absolutely not a valid notion (see...
  4. Michael Harrop

    Donor quality and stool type hypothesis for FMT (Fecal Microbiota Transplant)

    I've discussed and listed this sporadically in various places, including the wiki, so I'm compiling it all here. Also relevant is my FMT roadmap proposal (2019). Intro: Most clinical trials, and other sources of stool/stool donors, have been operating on the notion that they can find...
  5. Michael Harrop

    South Park season 23 episode 8 "Turd Burglars" covers FMT! "Kyle’s mom looks so good after her fecal transplant that everyone wants to get their hands on her goods. Cartman and the boys jump into the quest for the best microbiome." (2019)

    Full episode: https://southpark.cc.com/full-episodes/s23e08-turd-burglars Various clips on their Twitter: https://twitter.com/SouthPark I think this is a very good development. Anything that gets FMT more known by the general public should be greatly beneficial for us and the future of FMT...
  6. Michael Harrop

    Donor matching vs niches. Opinion on article titled "Could Donor Matching Help Fecal Transplants to Work Better?" Study: MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection (2015)

    The article/study is from 2015 but someone brought it up recently in another discussion. Article/interview: https://healthcare.utah.edu/the-scope/shows.php?shows=0_6699tga9 Reporting on this study: MHC variation sculpts individualized microbial communities that control susceptibility to...
  7. Michael Harrop

    In response to criticism about Steve Baskin's lastplace.org.au shipping non-frozen stool for as long as 8 days, I've looked at the evidence I'm aware of in regards to freezing, refrigerating, and room temp storage. (2021)

    There was a criticism made about Steve Baskin's https://lastplace.org.au, regarding him using a non-frozen shipping method that takes as long as a week https://web.archive.org/web/20210414080155/https://lastplace.org.au/product/fmt/ It would be nice if shipping fresh stool by ground (5 days)...
  8. Michael Harrop

    Results from 16,000+ new stool donor applicants. (2021, HumanMicrobes.org)

    Firstly, I wanted to delay this announcement due to issues surrounding another stool provider lying to their "customers". But many people have been urging me to make a donor available ASAP. There was a pause in our "hiring recruiters" strategy. But at the same time, we received an even bigger...
  9. Michael Harrop

    Though the results of screening 6000+ stool donor applicants was in no way surprising, and simply reflected what I see in person as well as on the internet, the results are still nothing short of horrifying, extremely alarming, and utterly dystopian. (2021, HumanMicrobes.org)

    We (https://www.humanmicrobes.org) got very lucky that one or more people organically made social media videos about us, which resulted in 450k+ views and 5000-6000 new donor applications. Unfortunately, I don't think any of the applicants are promising, and I'm not personally interested in...
  10. Michael Harrop

    FDA announces public hearing in Maryland on Nov 4, 2019 to obtain input on the use of fecal microbiota transplantation (FMT) to treat Clostridium difficile infection not responsive to standard therapies. Electronic submissions accepted. (2019)

    They're still only getting input for c.diff... what about FMT clinical trials for other conditions... those need regulation too. Direct link for docket to comment on: https://www.regulations.gov/document?D=FDA-2019-N-3631-0001 Here's what I'm writing up to submit. Feel free to give me your...
  11. Michael Harrop

    Attractiveness, facial features, health & development, and FMT donor selection. (Jul 2019)

    Main link: https://forum.humanmicrobiome.info/threads/attractiveness-facial-features-and-health-development.32/ I thought this was important enough for its own thread because from what I've seen the vast majority of people, including doctors and researchers in the FMT/microbiome field, seem to...
  12. Michael Harrop

    Another letter to the NIH (and FDA). Cancer patients as FMT donors. If you care about the future of FMT please consider also writing to them. (Mar 2019)

    Sent to NIH https://www.nih.gov/about-nih/contact-us I received a reply saying That seemed odd, but I guess the FDA is responsible for this. So sent it to [email protected] (EDIT: posted comment with their response). It seems like much of the research is done at universities and thus the...
  13. Michael Harrop

    Experiment with "enema only" vs "top-down/oral/capsules". Colon-only methods do not seem complete. Particularly for bile acid metabolism issues. (Jan 2019)

    I used a donor I knew to be able to fix bile acid metabolism. In the past, I did both oral and enema. After taking high dose iodine, which killed off the beneficial microbes I got from them, I decided to experiment with enema only vs oral this time around. I also did one enema using filtered...
  14. Michael Harrop

    Another email I've been sending to researchers regarding donor quality (Nov 2018)

    I'm writing about your donor quality criteria. Virtually all FMT trials, stool banks, clinics, etc. are using low-quality donors. The current criteria for donor quality is completely inadequate. Why this is, I can only guess that the people in charge do not follow the literature closely, have a...
  15. Michael Harrop

    My letters to the FDA and NIH. Sharing these both for the info, and as a template and encouragement for others to push for higher donor quality. (Nov 2018)

    I made some minor updates to the text/links. FDA: Center for Drug Evaluation and Research (CDER)1-855-543-3784 or 1-301-796-3400 or [email protected] Center for Biologics Evaluation and Research (CBER)1-800-835-4709 or 1-240-402-8010 or [email protected] I sent to [email protected], got a...
  16. Michael Harrop

    Analysis of OpenBiome's safety and efficacy (Aug 2018)

    EDITs: I find it pretty concerning that I shared this with both OpenBiome and the FDA yet 5-6 months later people are still reporting developing the same allergies and food intolerances after using OpenBiome donors, which strongly suggests that nothing has been done. Their questionnaire doesn't...
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