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  1. Michael Harrop

    Blog High-quality stool donors are more rare than one in a million? AI, funding, and potential. (Mar 2024, HumanMicrobes.org)

    Some of those claims need citations. It is more so that damaged gut microbiomes are the norm [1][2], even in the top echelon of athletes. My comment here is also relevant.
  2. Michael Harrop

    Antibiotics Large study finds antibiotics aren't effective for most lower tract respiratory infections (Apr 2024, n=718) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection

    Would a study like this immediately change the way you prescribe antibiotics for this particular use case of lower tract respiratory infections? Or do you wait for some other guidelines to get updated?
  3. Michael Harrop

    Blog The evidence and rationale supporting our stool donor criteria (2022, HumanMicrobes.org)

    Someone who used HM's donors also did FMT from the Hadza. He got short-term benefits but detriments in the long term due to pathogens he picked up from them. But he described some of their traits as "super-human". The Hadza are closer to what an "average human" should be. The "average human" in...
  4. Michael Harrop

    FMT for candida albicans overgrowth?

    There is one case report in the wiki https://humanmicrobiome.info/candida/#fmt.
  5. Michael Harrop

    FMT Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation (Apr 2024)

    I also had chronic sciatica pain (and arthritis pain) cured via FMT. Definitely would. https://humanmicrobiome.info/brain/
  6. Michael Harrop

    Vaccines Universal vaccine may be effective against any variant of any virus (Apr 2024) Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells

    https://www.earth.com/news/universal-vaccine-may-be-effective-against-any-variant-of-any-virus/ https://medicalxpress.com/news/2024-04-vaccine-strategy-line-endless-boosters.html https://www.pnas.org/doi/10.1073/pnas.2321170121
  7. Michael Harrop

    Antibiotics Large study finds antibiotics aren't effective for most lower tract respiratory infections (Apr 2024, n=718) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection

    https://medicalxpress.com/news/2024-04-large-antibiotics-effective-tract-respiratory.html https://link.springer.com/article/10.1007/s11606-024-08758-y And they STILL largely ignore the effects of collateral damage of antibiotics https://humanmicrobiome.info/antibiotics/.
  8. Michael Harrop

    Blog Half a million stool-donor applicants... (2023, HumanMicrobes.org)

    I'm a patient, not a doctor. No personal trainer is required for the HumanMicrobes.org physical assessment, but people can include whatever extras they like.
  9. Michael Harrop

    The gut microbiome, COVID-19, and long COVID [collection of studies]

    I saw news about "Chairman Bernie Sanders Releases Long COVID Moonshot Legislative Proposal", and I wanted to make a post listing the research I've seen on this. From what I see in their proposal, they're allocating 1 billion dollars into general research. I find this very frustrating given...
  10. Michael Harrop

    FMT Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice (Apr 2024)

    It’s not an FMT forum. Anything microbiome & health-related is fine. FMT is simply the most promising, complete, and studied intervention.
  11. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Yes, it's briefly discussed here https://forum.humanmicrobiome.info/threads/chlorine-in-treated-drinking-water.320/. I don't think they're promising, and even if they were, the logistics would be difficult.
  12. Michael Harrop

    FMT and male pattern baldness [hair loss, alopecia]

    It is merely one of dozens of people haphazardly going about FMT without adequate learning, and thus using a low-quality donor that they mistakenly thought was a good donor. There is no good evidence for sex-matching, and universal donors are the norm. So you found a clinic that is willing to...
  13. Michael Harrop

    FMT and male pattern baldness [hair loss, alopecia]

    That assurance is meaningless. Review this https://humanmicrobiome.info/where-to-get-fmt/ thoroughly, including the list of questions to ask them. There's a wiki section on hair loss https://humanmicrobiome.info/intro/#alopecia-hair-loss which I'll add to now. I don't think that makes sense...
  14. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    In large part, it's still unknown how these microbes get passed down generationally, and how exactly the infant microbiome develops https://humanmicrobiome.info/origins/, but with adults, FMT appears to be the only way. Better for its own thread, but from...
  15. Michael Harrop

    Gut microbiome and personality

    Yes. I don't think that's a valid way to go about FMT. "I'm high in X so find a donor low in X". Rather, look for a donor with an eubiotic, disease-resistant, unperturbed microbiome. People with all sorts of disorders and diseases would all benefit from the same "super-donor".
  16. Michael Harrop

    Gut microbiome and personality

    That was something I was curious and concerned about when I started out looking for a donor. Overall, FMT does not transfer personality, other than making you a better or worse version of yourself. It can certainly cause changes to "character traits", but largely only in so much as improving or...
  17. Michael Harrop

    Thoughts on HumanMicrobes donor problem

    Any intervention other than FMT is extremely limited since they will not add host-native microbes. So while there are a number of ways (diet, lifestyle) one can improve their health and gut microbiome, FMT is the only intervention that would be able to significantly "upgrade" a stool donor. This...
  18. Michael Harrop

    Gut microbiome and intelligence

    Yes, I think creativity is a component of intelligence.
  19. Michael Harrop

    Other Infections after surgery are more likely due to bacteria already on your skin than from microbes in the hospital. Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery (Apr 2024, n=204)

    https://theconversation.com/infections-after-surgery-are-more-likely-due-to-bacteria-already-on-your-skin-than-from-microbes-in-the-hospital-new-research-227435 https://www.science.org/doi/10.1126/scitranslmed.adk8222
  20. Michael Harrop

    FMT Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice (Apr 2024)

    I don't think it's entirely permanent. I've experienced drastic shifts myself, and seemingly-permanent damage, but still can and have recovered to high levels https://forum.humanmicrobiome.info/threads/gut-microbiome-and-intelligence.263/#post-553.
  21. Michael Harrop

    Blog Half a million stool-donor applicants... (2023, HumanMicrobes.org)

    Everyone just got an update. It may have landed in spam.
  22. Michael Harrop

    Article Decaf coffee is not safe for human consumption, health advocacy group warns (Apr 2024)

    https://www.wfsb.com/2024/04/06/decaf-coffee-is-not-safe-human-consumption-health-advocacy-group-warns/ Is decaf coffee safe to drink? Experts weigh in on claims by health advocacy groups https://www.cnn.com/2024/04/04/health/decaf-coffee-methylene-chloride-cancer-wellness/index.html
  23. Michael Harrop

    Purety Clinic experience?

    $600 per enema, 6x the cost of other sources. Making the "don't lose hope if you think you'll never be able to afford FMT" comment seem odd. This is not a valid notion based on any evidence I've seen. I'm doubtful that you understood the important factors to consider, since nothing you've said...
  24. Michael Harrop

    Is human microbes getting shut down?

    This may be an opportunity to get support and continue as a clinical trial: fas.org (Federation of American Scientists) Day One Project policy proposal for FMT Please share your feedback and ideas.
  25. Michael Harrop

    Blog Half a million stool-donor applicants... (2023, HumanMicrobes.org)

    At this point, it may be mildly helpful if you were one of the top ~50 candidates. You'd be notified by email if that were the case, and that discussion would take place via email.
  26. Michael Harrop

    Blog High-quality stool donors are more rare than one in a million? AI, funding, and potential. (Mar 2024, HumanMicrobes.org)

    I finished emailing 1.2 million people about this. The responses were depressing as hell. Overwhelmingly, the answer to: is absolutely nothing. A mere handful of people, out of 1.2 million, offered some type of small contribution. Even philanthropic individuals like Jimmy Donaldson (AKA...
  27. Michael Harrop

    FMT FDA warning over 'gut-boosting' pills that contain other people's POOP, amid links to deadly bacterial infections (Apr 2024, DailyMail, Human Microbes)

    https://web.archive.org/web/20240406175051/https://www.dailymail.co.uk/wellness-us/article-13238001/FDA-warning-poop-pills-infection.html The article gets some things wrong, such as: Nowhere in the FDA letter does it say "mislead" or "harm" or "false". Things like this are why the Daily Mail...
  28. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    The Challenge: What is the pressing issue that society is facing? (50–100 words) Rampant and increasing chronic disease. https://forum.humanmicrobiome.info/threads/chronic-disease-and-general-poor-health-have-been-drastically-increasi.44/ The Opportunity: What is your idea for solving that...
  29. Michael Harrop

    fas.org (Federation of American Scientists) Day One Project policy proposal for FMT

    Katie McCaskey wrote to me on Mastodon: I took a look at the link and I'm working on writing up something about FMT/Human Microbes to submit, but I see "What are specific steps the federal government can take to implement your solution?". I'm doubtful that the feds are the best option to...
  30. Michael Harrop

    FMT Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases (2022)

    Another interesting result from Fecal Microbiota Transplantation engraftment after budesonide or placebo in patients with active ulcerative colitis using pre-selected donors: a randomized pilot study (Apr 2024, n=24) "clinical response appeared donor-dependent"
  31. Michael Harrop

    Is human microbes getting shut down?

    Thank you Joseph! Testing stool samples is covered in the most recent blog, and the wiki.
  32. Michael Harrop

    Yes, that is covered in the wiki https://humanmicrobiome.info/fmt/#procedure. It's true that...

    Yes, that is covered in the wiki https://humanmicrobiome.info/fmt/#procedure. It's true that people can benefit from low-quality donors, but it's a matter of risk vs reward, and percentages. How many other people would benefit from that donor? How many would be harmed? That is what I try to...
  33. Michael Harrop

    FMT Fecal microbiota transplant eases Parkinson’s symptoms (Mar 2024, n=46) Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial

    https://parkinsonsnewstoday.com/news/fecal-microbiota-transplant-eases-parkinsons-symptoms-trial/ https://www.sciencedirect.com/science/article/pii/S2589537024001421 Standard, poor donor quality. Stool type not even considered. 0% chance they found 17 high-quality donors.
  34. Michael Harrop

    Is human microbes getting shut down?

    FDA Enforcement Discretion and EUAs (Emergency Use Authorization): https://www.fdaimports.com/the-difference-between-fda-enforcement-discretion-and-euas/ https://www.thehartford.com/insights/life-science/enforcement-discretion-for-life-science-companies FMT, and the patient need for it...
  35. Michael Harrop

    Is human microbes getting shut down?

    This is irrelevant/non sequitur. Relatedly, I think the only person in the world that comes close to matching my knowledge of FMT is another patient. There is no one in the world I would look to for advice on FMT, but his input can be useful. This reflects the nature and status of FMT. Stool...
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