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  • I’m new here and I’m very excited to find this exceptional resource for everything microbiome! Thank you!
    I’m interested in your thoughts about using young, healthy, well-matched donors for microbiota transfer treatments from the rest of the body (besides stool) including: oral (separate multi-kingdom communities including biofilms from the oral cavity), vaginal, nasal, skin, and so forth. I know that vaginal microbiota transplants have been used successfully for bacterial vaginosis, but I can foresee a future where everything from tears and menstrual blood to volatile organic compounds from the lungs and more being used to save lives! Everything previously thought as simply waste products being used instead to reboot an older and/or weaker body. Can you imagine how wonderful it would be to see healthy young people compensated for everything they would’ve ordinarily thrown away? Ideally one would find a few excellent “mini-me’s” that would be available for donations.
    My other question is, looking for the best donor, why wouldn’t it be a good idea to find the best fit possible, for example, matching blood types, sex, and possibly key genetics such as the major histocompatibility genes? (In addition to the very best screening techniques for any pathogens.)
    Also, although there may not be clinical trial results available yet for the perfect protocols, if one has major inflammation caused by a variety of pathogens, why wouldn’t we try eliminating the pathogens effectively first; such as using antibiotics, anti-fungals, anti-parasitics, antivirals and/or bacteriophages as needed, to eradicate the pathogens before the transplants?
    I would love to hear what your thoughts are about these questions.
    Michael Harrop
    Michael Harrop
    You commented on your own profile instead of making a new thread.

    Most of your questions are also answered in existing threads.
    S
    SFBayFMT5
    I suspect that the microbiota most direly missing from my own intestinal tract are mostly facultative anaerobic small intestinal microbes (things like Actinomyces, Gemella, non-Copri strains of Prevotella, possibly Neisseria, etc.), NOT the kind of colonic anaerobes that are entirely focused on in nearly all studies of FMT (i.e. the clostridium clusters, Bacteroides, and purely fermentative actinobacteria like Bifidobacterium, Eggerthella, Collinsella, etc.). This is actually the single biggest methodological issue I have with the FMT studies to date.

    These bacteria have much more in common with the oral microbiome than the fecal microbiome, hence I have a suspicion that oral microbiota capsules would work better than fecal ones. They would at least be much easier on the donor than trying to collect from the small intestine itself. You'd obviously need to do something to ensure good oral health, including the absence, or at least minimal presence, of proteolytic fermenters like Tannerella, Porphyromonas, Treponema etc., which I DON'T think you want to transmit. But using material sourced from higher up like this would eliminate the issue of large numbers of rectal bacteria being introduced into the upper GI tract and causing bloating, indigestion, "brain fog", and other similar symptoms that seem to be very common in oral FMT reports here and elsewhere.

    If you're aware of anyone actually working to make this a reality, I'd be happy to hear about it and give it a try. I've been looking for something like this for a long time.
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