Recent content by indigo34

Too bad it's not open access. Results seem way overstated. They didn't use normal mice but antibiotic-treated mice. That likely dramatically affected their results and therefore makes them less translatable to situations where FMTs are given without antibiotic pre-treatment. Interesting they...

The references mention analyzing fetal tissue samples so I assume the article followed the same methodology. They don't specify how they obtained the samples in most cases but I suspect it was through abortion procedures. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30737-3...

I wonder if someone read the letter I gave to Senator Cassidy or if they were already aware of the connection. I never heard anything back of course though. He mentions it again around 12 minutes in. If they (HHS) come out and say there is a connection between autism and the microbiome I feel...

I suppose you haven't read this: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT (2018) https://www.cell.com/cell/fulltext/S0092-8674(18)31108-5?

Relevant text of the article: It seems like the microbiome could fit into RFK's framework of ideas, if he is willing to make some modifications. He is right that too much focus was taken off fortifying the immune system, which the microbiome heavily influences, and instead on manufacturing...

I heard Martin Makary say in an interview that he believes microbiome disruption to be the most likely cause of autism, so hopefully he already relayed that information to RFK. I'm hoping for the same with respect to his influence.

Resarchers have looked at the deeper layers of mucosa and got good results? You said they didn't: I have been researching the mucosa layers and everything I've read indicates the microbiome exists within the lumen and the mucus layers on top of the mucosa's epithelial layer, and the deepest it...

If you can't provide any studies that have looked at the layers of the mucosa you speak of in your theory then I don't understand why you are so convinced you are right, to be honest. It seems to me to be based on a hunch or speculation and not scientific underpinnings. I understand why you want...

That's how I interpreted "clearing the microbiome," I'm glad that isn't your goal. If you had said partially clearing or suppressing the microbiome I would have gotten your meaning sooner. Apologies for the misunderstanding on my part. I get that this is what you think is happening but I do not...

Yeah I don't think you can draw many conclusions about what it would take to clear the microbiome in the colon, and what the result would be, from the mucosa-destroying study in the duodenum. That's my opinion. The colon and duodenum are very different, especially with respect to the...

Not sure if this is the right thread to post this in, but I have a few questions about the details of the "clearing existing microbiome" clinical trials we are asking the NIH to do. If all these questions have been answered elsewhere feel free to delete. Are these human trials, animal trials...

Interesting this probably helps explain the mechanism by which vaccines can lead to autoimmune disease in some individuals. Not surprised at all that they gave antibiotics to healthy people. I was prescribed amoxicillin for a bacterial sinus infection that I was told would clear up on its own...

This is super interesting.

That's super interesting that they studied this. Maybe looser stool tend to contain a larger percentage of bacteria that are competitive with C. diff, or fill a similar niche, as opposed to firmer stools. Just speculating.

Just watched the clip, wow that's great they understand about antibiotic overuse and the microbiome, even better than I thought from the interview I heard. He said the risk of suicide is 3x greater in the year after taking antibiotics. I don't know if that's true but the fact of him saying that...