Recent content by indigo34

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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    The first is a decent paper showing non-significant changes in Shannon diversity following FMT in non-responders. See Figure 1A, the first box. The second paper also says "Of note, microbiome richness of the patient with an IBD diagnosis did not increase after FMT, and post-FMT β diversity...
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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    First of all, FMT does not always increase microbiome diversity. Second, their findings are expected based on known ecology and how ecosystems collapse in nature. That's why it's an expected result. Because the gut is an ecosystem too. The reason I find it frustrating is because they don't...
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    Study A 'consortium' of bacteria cooperates to eat phthalate plasticizers that single microbes can't stomach (March 2026) Cross-feeding drives degradation of phthalate ester plasticizers in a bacterial consortium

    https://phys.org/news/2026-03-consortium-bacteria-cooperates-phthalate-plasticizers.html
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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    This result is not surprising at all. It's well-known diversity is lower in dysbiotic microbiomes. A dysbiotic microbiome/ more hostile gut environment wouldn't be able to support competition as well because the slightly less-fit or less well-adapted competitors would die off or struggle to...
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    General health Using AI chatbots for medical advice

    ChatGPT was able to predict my colonoscopy results which was interesting.
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    Diet A common food ingredient may shape a child’s health for life (Jul 2025, mice) Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility. Carboxymethylcellulose and polysorbate-80

    In other words, the negative effects of emulsifier consumption were caused by its effect on intestinal mucus-mediated signaling.
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    Testing We may finally know what a healthy gut microbiome looks like (Dec 2025, n=34,694) Gut micro-organisms associated with health, nutrition and dietary interventions

    That was underwhelming lol
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    Other Non-antibiotic medications leave lasting mark on gut microbiome, even years after use (Sep 2025) A hidden confounder for microbiome studies: medications used years before sample collection

    I know so many people on these medications. Doctors love to give out SSRIs. I hope this information eventually gets to be more widely known for both doctors and patients. But given antibiotic collateral damage does not seem to be recognized as an extremely serious problem by most...
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    Article Studies deliver new blow to cancer microbiome literature—and offer a way forward. Two analyses of microbial DNA in tumor samples aim to put controversy-riddled field back on track (Sep 2025, Micronoma)

    Well maybe unnecessary colonoscopies can still be avoided in the future. Good news because they are very disruptive to the microbiome. Other cancers often have less invasive and microbiome-harming tests available.
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    FMT Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies (Sept 2025)

    I looked at the two clinical trial descriptions where they got the data from and they mention using fresh stool and delivering it via gastroscope to the mid-gut and via Colonic Transendoscopic Enteral Tubing (TET) device in the other. So fresh/ upper route is my interpretation. Interesting...
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    Study Mount Sinai study supports evidence that prenatal acetaminophen use may be linked to increased risk of autism and ADHD (Aug 2025, review) Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology

    Aren't women in pain (which is partially mediated by the microbiome) more likely to take pain relievers? So couldn't the real association be, women who experience more pain are more likely to take Tylenol during pregnancy and it's more the desire for pain relief demonstrating the effect than the...
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    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    Can you provide a source on this? I've heard they are looking into other types of AI but my understanding was that the best and closest to AGI were all LLMs. I have not done much research in this area though. I've heard that the so-called "alignment problem" - AI being aligned to human...
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    Article FDA names former pharmaceutical company executive, Dr. George Tidmarsh, to oversee US drug program, CDER (2025)

    It seems like you're conflating a lot of different things with this statement or perhaps I am misunderstanding you. It seems like you are calling me naive and a MAGA supporter. Is that correct? I'm definitely not part of "MAGA." I am located in the U.S. but I've never voted for Trump. My...
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    Article FDA names former pharmaceutical company executive, Dr. George Tidmarsh, to oversee US drug program, CDER (2025)

    I've changed my opinion of Makary after hearing more of his interviews and reading more articles about what he's doing. He seems pro big-pharma when initally he was claiming to be skeptical.
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    Article Finch wins US jury trial against Ferring over fecal-transplant patents (Aug 2024, Rebyota)

    Would it be worth trying to contact Finch? About improving the quality of their donors and getting their product approved for other conditions (i.e. IBS) From their website it seems like they are trying to patent FMT for C. diff, autism, IBD, Parkinson's, etc, and they have 70 patents related...
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