Recent content by indigo34

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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    If you can't provide any studies that have looked at the layers of the mucosa you speak of in your theory then I don't understand why you are so convinced you are right, to be honest. It seems to me to be based on a hunch or speculation and not scientific underpinnings. I understand why you want...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    That's how I interpreted "clearing the microbiome," I'm glad that isn't your goal. If you had said partially clearing or suppressing the microbiome I would have gotten your meaning sooner. Apologies for the misunderstanding on my part. I get that this is what you think is happening but I do not...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Yeah I don't think you can draw many conclusions about what it would take to clear the microbiome in the colon, and what the result would be, from the mucosa-destroying study in the duodenum. That's my opinion. The colon and duodenum are very different, especially with respect to the...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Not sure if this is the right thread to post this in, but I have a few questions about the details of the "clearing existing microbiome" clinical trials we are asking the NIH to do. If all these questions have been answered elsewhere feel free to delete. Are these human trials, animal trials...
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    Antibiotics Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine (Apr 2025, n=18)

    Interesting this probably helps explain the mechanism by which vaccines can lead to autoimmune disease in some individuals. Not surprised at all that they gave antibiotics to healthy people. I was prescribed amoxicillin for a bacterial sinus infection that I was told would clear up on its own...
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    FMT Effects of clinical donor characteristics on the success of faecal microbiota transplantation for patients in Denmark with Clostridioides difficile infection: a single-centre, prospective cohort study (Feb 2025) sex, age, BMI, bristol stool type, antibiotic use, H pylori, birth mode, alpha diversity

    That's super interesting that they studied this. Maybe looser stool tend to contain a larger percentage of bacteria that are competitive with C. diff, or fill a similar niche, as opposed to firmer stools. Just speculating.
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Just watched the clip, wow that's great they understand about antibiotic overuse and the microbiome, even better than I thought from the interview I heard. He said the risk of suicide is 3x greater in the year after taking antibiotics. I don't know if that's true but the fact of him saying that...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I can take another day this month to go there. Do you know when he is most likely to be there so I can increase the chances of seeing him? I'll draft up a letter too based on your other post on it. I think I'll emphasize the microbiome-autism connection though and possibly use the Alzheimer's...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    This seems like the best we could have hoped for since Cassidy seems a lot more accessible than Kennedy. You literally talked to him and he took some time to listen. I don't know if Senator Cassidy knows that there is a microbiome connection to autism, possibly even in a majority of cases, but...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Well it's at least partially correct i.e. lower route which obviously bypasses those things. We certainly should not be assuming mouse FMT is directly comparable to lower route human FMT, especially considering the differences sometimes seen between human upper and lower route FMT. Or do you...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    There are several factors to consider when translating the conclusions of this and other FMT mouse studies to humans that I did not elucidate in my previous post. Mouse FMTs do not bypass any of their GI tract while human FMTs seek to bypass the acid-producing stomach and antimicrobial-compound...
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    Impact of gut health on food poisoning or sensitivities

    I have not read the studies on fermented foods in healthy people so I'll take your word for it since I don't plan on reading them anytime soon. (I would if I had more time/energy and was considering trying them though.) I have seen fermented foods widely promoted and I suppose I bought into the...
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    Impact of gut health on food poisoning or sensitivities

    I was responding to this person's individual situation and not everyone as general advice. This person mentioned being healthy and having no gut problems.
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    This is a literature review I did evaluating the above-cited evidence that there is a significant difference between the mucosal and fecal microbiomes in humans. My conclusion is that there is insufficent evidence due to two issues with the research: 1) the use of mouse studies and 2) the use of...
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