Recent content by indigo34

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    Procedure Looking for advice on autologous FMT

    I'm sorry you had that experience. When I get prescribed antibiotics, sometimes I just say ok in the moment to avoid conflict, and then later research whether I feel the potential benefit is worth the risk before taking them.
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    Parasites An anti-parasitic medication (ivermectin) shifted Amazonian villagers’ microbiomes toward an urban profile (May 2026, n=335) Rapid microbiome restructuring associated with medical exposure in remote Amazonian Indigenous communities

    While I agree that helminths likely affect microbiome composition, I think it's inaccurate to imply that everyone with worms is necessarily "sick" with them by definition. It depends heavily on species and worm burden. Many low-burden helminth infections are asymptomatic or minimally...
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    I meant the infection risk from vaginal bacteria specifically. Since that seemed to be the concern in the original paper.
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    Origins Vaginal bacteria on newborn skin produce a lipid that reaches the brain and affects neural signaling (Apr 2026) Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

    I agree. The reductionist philosophy of medicine is everywhere and incredibly frustrating, and germ theory is taught as fact even though it's obviously incomplete. C. diff and H. pylori being two obvious examples. When I read this line: I rolled my eyes so hard. It just sounds so, so stupid...
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    Procedure Looking for advice on autologous FMT

    A family member of mine was recently bit by a dog. We cleaned the wound thoroughly and went to urgent care the next day. Although urgent care prescribed the same antibiotic (Augmentin) I asked them about watchful waiting. They said less than 10% of dog bites get infected and while she could not...
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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    The first is a decent paper showing non-significant changes in Shannon diversity following FMT in non-responders. See Figure 1A, the first box. The second paper also says "Of note, microbiome richness of the patient with an IBD diagnosis did not increase after FMT, and post-FMT β diversity...
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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    First of all, FMT does not always increase microbiome diversity. Second, their findings are expected based on known ecology and how ecosystems collapse in nature. That's why it's an expected result. Because the gut is an ecosystem too. The reason I find it frustrating is because they don't...
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    Study A 'consortium' of bacteria cooperates to eat phthalate plasticizers that single microbes can't stomach (March 2026) Cross-feeding drives degradation of phthalate ester plasticizers in a bacterial consortium

    https://phys.org/news/2026-03-consortium-bacteria-cooperates-phthalate-plasticizers.html
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    Testing Gut health index measures microbial interactions to track disease (Feb 2026) Imbalance in gut microbial interactions as a marker of health and disease

    This result is not surprising at all. It's well-known diversity is lower in dysbiotic microbiomes. A dysbiotic microbiome/ more hostile gut environment wouldn't be able to support competition as well because the slightly less-fit or less well-adapted competitors would die off or struggle to...
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    General health Using AI chatbots for medical advice

    ChatGPT was able to predict my colonoscopy results which was interesting.
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    Diet A common food ingredient may shape a child’s health for life (Jul 2025, mice) Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility. Carboxymethylcellulose and polysorbate-80

    In other words, the negative effects of emulsifier consumption were caused by its effect on intestinal mucus-mediated signaling.
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    Testing We may finally know what a healthy gut microbiome looks like (Dec 2025, n=34,694) Gut micro-organisms associated with health, nutrition and dietary interventions

    That was underwhelming lol
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    Other Non-antibiotic medications leave lasting mark on gut microbiome, even years after use (Sep 2025) A hidden confounder for microbiome studies: medications used years before sample collection

    I know so many people on these medications. Doctors love to give out SSRIs. I hope this information eventually gets to be more widely known for both doctors and patients. But given antibiotic collateral damage does not seem to be recognized as an extremely serious problem by most...
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    Article Studies deliver new blow to cancer microbiome literature—and offer a way forward. Two analyses of microbial DNA in tumor samples aim to put controversy-riddled field back on track (Sep 2025, Micronoma)

    Well maybe unnecessary colonoscopies can still be avoided in the future. Good news because they are very disruptive to the microbiome. Other cancers often have less invasive and microbiome-harming tests available.
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    FMT Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies (Sept 2025)

    I looked at the two clinical trial descriptions where they got the data from and they mention using fresh stool and delivering it via gastroscope to the mid-gut and via Colonic Transendoscopic Enteral Tubing (TET) device in the other. So fresh/ upper route is my interpretation. Interesting...
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