Recent content by indigo34

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    FMT Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability (Jul 2025, n=12, enema over 6 mo, Biomebank) No significant motor symptom changes. No sustained improvement in non-motor symptoms.

    It's interesting that there was a trend toward reduced daily off time during the "induction phase" of about 1 FMT per week that disappeared when they switched to the "maintenance phase" of 1 FMT per month.
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    Has anyone else tried Keto Diet or similar to modify their gut biome?

    I've been on a ketogenic diet for a little over a year. That's because carbs tend to give me extreme bloating and discomfort. Fiber makes things worse for me too (causes loose stool and urgency) especially soluble fiber. Keto hasn't magically cured me but I feel less bad eating that way...
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    Study Some scientists are using chatbots to write all or part of their papers. 454 words that have increased in studies since ChatGPT was released (Jul 2025) Delving into LLM-assisted writing in biomedical publications through excess vocabulary

    This is scary. AI sometimes hallucinates citations that don't exist, which apparently happened in the recent MAHA report. I wonder if that's happened in other recent peer-reviewed studies. We know AI lies often too, so I don't see why they think it would be safe to use in scientific studies -...
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    Other H. Pylori bacteria that causes stomach ulcers may protect the brain from Alzheimer’s and Parkinson’s (Jun 2025) Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

    Is this actually true? At least for Alzheimer's I thought that the research demonstrating there is a causal relationship was falsified, and that the drugs they developed based on this theory, which target beta-amyloid plaques, do not help Alzheimer's patients...
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    FMT Fecal transplants: Study is a 'wake-up call' for the field as researchers identify unintended consequences. (Jun 2025, mice) Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

    Too bad it's not open access. Results seem way overstated. They didn't use normal mice but antibiotic-treated mice. That likely dramatically affected their results and therefore makes them less translatable to situations where FMTs are given without antibiotic pre-treatment. Interesting they...
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    Early development In utero human intestine contains maternally derived bacterial metabolites (May 2025, n=21)

    The references mention analyzing fetal tissue samples so I assume the article followed the same methodology. They don't specify how they obtained the samples in most cases but I suspect it was through abortion procedures. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30737-3...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I wonder if someone read the letter I gave to Senator Cassidy or if they were already aware of the connection. I never heard anything back of course though. He mentions it again around 12 minutes in. If they (HHS) come out and say there is a connection between autism and the microbiome I feel...
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    Diet Diet outperforms microbial transplant to drive microbiome recovery in mice (April 2025)

    I suppose you haven't read this: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT (2018) https://www.cell.com/cell/fulltext/S0092-8674(18)31108-5?
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    Relevant text of the article: It seems like the microbiome could fit into RFK's framework of ideas, if he is willing to make some modifications. He is right that too much focus was taken off fortifying the immune system, which the microbiome heavily influences, and instead on manufacturing...
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    Healthcare system Incoming trump admin with RFK signals new start for FDA

    I heard Martin Makary say in an interview that he believes microbiome disruption to be the most likely cause of autism, so hopefully he already relayed that information to RFK. I'm hoping for the same with respect to his influence.
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Resarchers have looked at the deeper layers of mucosa and got good results? You said they didn't: I have been researching the mucosa layers and everything I've read indicates the microbiome exists within the lumen and the mucus layers on top of the mucosa's epithelial layer, and the deepest it...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    If you can't provide any studies that have looked at the layers of the mucosa you speak of in your theory then I don't understand why you are so convinced you are right, to be honest. It seems to me to be based on a hunch or speculation and not scientific underpinnings. I understand why you want...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    That's how I interpreted "clearing the microbiome," I'm glad that isn't your goal. If you had said partially clearing or suppressing the microbiome I would have gotten your meaning sooner. Apologies for the misunderstanding on my part. I get that this is what you think is happening but I do not...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Yeah I don't think you can draw many conclusions about what it would take to clear the microbiome in the colon, and what the result would be, from the mucosa-destroying study in the duodenum. That's my opinion. The colon and duodenum are very different, especially with respect to the...
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    Enhancing Mucosal microbiota transplant, clearing the gut mucosa prior to FMT

    Not sure if this is the right thread to post this in, but I have a few questions about the details of the "clearing existing microbiome" clinical trials we are asking the NIH to do. If all these questions have been answered elsewhere feel free to delete. Are these human trials, animal trials...
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