Mold exposure and CIRS: theories on gut microbiome role in Chronic Inflammatory Response Syndrome

[IsthmusSIBO]

So, I am making a post here because I don’t have direct contact info (and because of your stance on no longer talking about your experiences if it helps others), but what is your opinion on Chronic Inflammatory Response Syndrome (CIRS), @Michael Harrop ?

I have been reading your case and you recall having breathing and heart problems with gradual CFS. I know you align it more with a deficient gut from birth, but are you sure you don’t have mold where you live? How did you feel back when you were living in your car?

I am sure you have your apprehension on believing any type of illness within the functional medicine scopeis real considering your stance on SIBO, but I wonder if that extends to this disease? If anything, treating CIRS seems less dangerous than treating SIBO. Yet it is much more complex and unfeasible for most, as it pertains having to remove from exposure of mold, which is everywhere.

Literature review on CIRS: https://pmc.ncbi.nlm.nih.gov/articles/PMC11623837/

 

[Michael Harrop]

If anything, treating CIRS seems less dangerous than treating SIBO

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This is nonsensical. What matters is how you treat the condition.

Chronic Inflammatory Response Syndrome (CIRS) is an acquired medical condition characterized by innate immune dysregulation following respiratory exposure to water-damaged buildings (WDB). This chronic syndrome involves a range of symptoms that simultaneously affecting multiple organ systems.

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The only treatment with documented clinical efficacy was the Shoemaker Protocol

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I reviewed the protocol, and much of what they're doing is targeting the gut microbiome and immune system with methods less effective than FMT. Based on what they're saying helps, FMT should help much more.

• https://humanmicrobiome.info/immune-system/
• https://humanmicrobiome.info/systemic/#lungs

 

[IsthmusSIBO]

This is nonsensical. What matters is how you treat the condition

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Sorry, I wrote that incorrectly. I meant that the treatment for CIRS seems less dangerous than the one for SIBO, as it doesn’t involve antibiotics.

FMT should help much more

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I think given your experiences and that of many others, not even a super donor can reverse a lifetime of accumulation of biotoxins, so getting a healthy gut transplant for a few months will help but not necessarily reverse something like CIRS. What everyone can agree though, is that the CIRS has a gut dysbiosis component.

Just wanted to inform on something you can research for your own issue.

 

[Michael Harrop]

I think given your experiences and that of many others, not even a super donor can reverse a lifetime of accumulation of biotoxins, so getting a healthy gut transplant for a few months will help but not necessarily reverse something like CIRS.

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That's not accurate. My experiences with "super-donors" is that they can cure most things, but I was unable to do enough FMTs from them, and it's important to have something that can clear out the existing microbiome. Additionally, I know what needs to be done, and it's plenty doable, but instead of being helped, I'm being severely hindered every step of the way.