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    Donors Donor quality and stool type hypothesis for FMT (Fecal Microbiota Transplant)

    I agree that the mucus-associated bacteria are probably more important than the luminal bacteria (which make up the majority of the poop) to transfer--especially since they're both more able to exchange metabolites directly with the host and have more access to oxygen from the gut wall to be...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    For most people in the medical field, the risk/benefit analysis looks very different than from the POV of a desperate patient, or even a dispassionate scientist studying the microbiome in an abstract and/or theoretical manner. Their entire worldview is unfortunately clouded by thoughts of...
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    Other Popularity and acceptance of FMT. Who is to blame for why FMT will never be available? Ignorance, laziness, and apathy of the general public? How to motivate people to take action?

    As far as I know, what first happened (at least in modern times) is doctors trying FMT for their patients in what were effectively informal clinical trials, when those patients had something like C. diff where there was no known cure that worked for the patients. At the time, since so few people...
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    Other Popularity and acceptance of FMT. Who is to blame for why FMT will never be available? Ignorance, laziness, and apathy of the general public? How to motivate people to take action?

    You don't specify who "these companies" are, but I'm guessing you mean just general companies that are successful doing business in the US. I don't think you can compare FMT marketing to selling of something like computer games, AI, "life hack" gadgets, vacation rentals, or anything like that...
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    Other Popularity and acceptance of FMT. Who is to blame for why FMT will never be available? Ignorance, laziness, and apathy of the general public? How to motivate people to take action?

    I think this is exactly it. And even people who are possibly worse in terms of objective sickness (if you can even measure that) are often sick in more visible and empathizable, "socially acceptable" ways, and see less of a gap between their current ability level and where they could be at if...
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    Sources Comparing commercial FMT providers

    That IS sketchy. You may be wondering why I'm saying that now, given that I didn't consider it fishy when I learned he had neglected to inform me that one recipient had had a negative response to one donor. The difference is if it is a pattern. I take it for granted that for every provider of...
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    Other Duplicating FMT, stool donor, and microbiome projects vs solving existing barriers

    I see it more as a case of "when all you have is a hammer, everything looks like a nail". Aim for NaN has coding skills, and can handle the web design better than most people, so that's where the focus goes, rather than looking for where the actual "weakest link" is in the process (which has...
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    Other Duplicating FMT, stool donor, and microbiome projects vs solving existing barriers

    I what way do you think that lack of coding expertise had anything to do with why HM was so difficult to start up? As I understand it, the barriers are: 1. Reaching out to quality donor candidates--i.e. the initial contact. A website might be coded perfectly and be very user-friendly, but if...
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    Other Duplicating FMT, stool donor, and microbiome projects vs solving existing barriers

    I heard (Michael unfortunately never shared the details, if he even knows) that it's when you market stool as a treatment. In other words, it's entirely on the marketing side. So NONE of these is illegal for you. As I understand it, most of them are also legal for the donor and/or the friend, as...
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    Other Duplicating FMT, stool donor, and microbiome projects vs solving existing barriers

    As Michael already said, he did not stop voluntarily, the FDA threatened legal action if he were to continue selling. You may have a point in that if there were 50 businesses selling FMTs in the US, that might be too many "flies" for the FDA to "swat" and so some would always stay open...
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    Sources Comparing commercial FMT providers

    When I had a bad result from one of GD's donors and was going to re-order more from the other donor who I improved from, Marco was very willing to help me get exactly what I needed. The order was a little complicated though, as I wanted to try an enema yet also get some more capsules (since I...
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    Donors Amish as stool donors for FMT

    This doesn't imply anything whatsoever about genetics, rather it implies something about bacterial utilization of lactose. Lactose intolerance occurs when there is insufficient lactase produced by the host to break down lactose, allowing bacteria to ferment the lactose and produce gas. So the...
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    Donors Amish as stool donors for FMT

    Is photographing stools really necessary, if you can explain to them what the different stool types look like and ask them to determine which is closest to theirs? Yes you need to trust them, but so do you with other health information like disease and family history (the pathogen testing you...
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    Donors Where to get a stool donor for FMT or how to find one?

    In short, nothing that traveling to San Francisco would help you with. One FMT was from OpenBiome, one donor (2 FMTs) was from Human Microbes, and two donors were from Gezonde Darmflora. OpenBiome, which was by far the most effective of those four, has been out of operation for several years...
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    Enhancing FMT reduced to less than 1% as effective as it used to be after i started taking high daily amounts of inulin prebiotics years ago (reason likely being severely damaging my gut mucus layer)

    It sounds as if the inulin provoked a sort of manic experience for you at high doses, possibly as a result of what your gut microbes metabolized it into. This is conceivable because I have felt similar states as a result of overgrowth of the wrong bacteria in my gut, when they're fed by certain...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    I don't mean he was necessarily an "average Joe"--he could have been a super important politician or businessman with lots of connections who is very well known in his circle of influence and still be a "random stranger" for these purposes. He could have even been in the healthcare field...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    I don't know if this is the right thread for this, but I watched most of your videos and had some comments. In one video, you mention that you approached a man who looked "visibly unhealthy", and he reacted " with astonishment that you came to that conclusion. Then when you educated him about...
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    Other What exactly is forbidden in the US with regards to FMT?

    So from the Science Forums thread it appears as if Rebyota can be used off-label--so shouldn't we be encouraging medical practices to go into the area of prescribing it for patients with damaged microbiomes? Back when I was undergoing Lyme treatment, there were a lot of questionable independent...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    I certainly am not ignoring it. My question though is, how can we band together and do some kind of community outreach to find the people who AREN'T turned off by this. Michael is trying to do this on a national scale, which is commendable--but if we all banded together to help each other find...
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    Other What exactly is forbidden in the US with regards to FMT?

    Ok so FMT IS considered "a drug" even when it is not manufactured by a pharmaceutical company. Are you referring here to your inability to recruit effective donors paying them as much as you did before? So it does seem like you would need to remove all mention of FMT then.
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    Other What exactly is forbidden in the US with regards to FMT?

    Some comments in the recent thread on Scienceforums.org made me think to ask this question. It's relevant to how exactly FMT products can or cannot be marketed in the USA, and hence to how a successor to Human Microbes would need to operate. People there were claiming that FMT is merely not...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    Umm... so now you're agreeing with the people who have been telling you that it's too experimental and has major risks? Again... so you're now agreeing that disgust is one of the main factors, when you have spent about five posts trying to convince us why it's insignificant in the larger...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    Just some points of clarification, as I suspect some people may misunderstand parts of the above--I'm NOT implying that FMT recipients mistreat donors in any way, or even tend to. Most of us are very nice to donors who we actually feel are promising, and very "down to earth" in our expectations...
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    Other What is the public perception of FMT? How much does it matter? Has it been blocking progress?

    In one of the Reddit threads you link, someone ("WalterBishRedLicrish") said the following: This seems to be exactly the sort of thing that NameHere was saying, and I have been noticing. There seems to be a strong aversion among many people to the idea of using something from a healthy...
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    Enhancing Cryoprotectants for stool/FMT. Capsules, glycerol vs maltodextrin antifreeze, -80 (medical freezer) vs -20 (home freezer)

    I'm wondering what were the alternatives/comparison groups.
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    Donors Thoughts on HumanMicrobes donor problem

    They may not look at stool type like you do, but they have looked at other things, in particular: -Use of proton pump inhibitors prior to upper route (Answer... it seems it's not very important, I think they even don't do it anymore) -Use of vancomycin pretreatment (Answer: improves the success...
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    Procedure Getting blood and stool testing for an FMT donor

    For those who found themselves private donors, when it came time to get the bloodwork done, how did you do it? Did you give the donor the list of tests and have him/her contact his/her doctor to get them ordered, then reimburse? or did you find a doctor online who would order them for the donor...
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    Procedure DIY FMT Beginner's Questions

    Just to add something to 2: In my case, improvement continues for at least a month if not longer after FMT. After my most successful FMT, there were a number of clear immediate (same day/week, this was an endoscopy procedure) changes, but the most dramatic changes happened right around the six...
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    Outcomes Body odor changes after FMT?

    -do you get the same body odor as your donor after a lot of fmts? or is it more of a temporary effect that's gone as soon as you finish the fmts? I have not smelled the body odor of any donors as I do not know any of them personally. I also haven't noticed major shifts in my BODY odor after FMT...
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    Sources Comparing commercial FMT providers

    I mean that there is no way to compare PROVIDERS without receiving data from people who have tried more than one. Saying merely that of five people who ONLY tried Microbioma, for instance, only two improved, while of four who ONLY tried Gezonde Darmflora, all four improved, doesn't necessarily...
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    Sources Comparing commercial FMT providers

    "Other people make brief comments here and there"--that gives no basis to evaluate the overall success rate of any provider. What you really need is to look for people who have tried more than one provider. Clearly there are people for whom finding the right provider and/or donor is MUCH harder...
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    Outcomes Please help - anxiety/panic after FMT+yellow stool

    It sounds like whoever you used was a poor match donor for you. The one donor I've tried who made me worse, it was a similar thing, it greatly flared my mental health issues (whereas good donors improve them--and my best donor, from OpenBiome, temporarily got my mental health the best it had...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    By the way, someone in a FMT group just mentioned this clinic in Portland, and I see they do autologous stool banking: https://drcarmencampbell.com/aboutme/. So this is a definite option if you want to do what I was saying above (save some of your microbiome prior to going on antibiotics). I...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    The opposite is true--autologous FMT will NOT restore critical species or strains that are entirely missing (unless the stool is collected before whatever stress--e.g. antibiotics--causes them to go extinct in your gut). Yes this concept IS correct. Each species of bacteria has certain...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    In my opinion, FMT is FAR too much of a gamble to be valuable if you have no health issues! In other words, it isn't something you do that's comparable to taking a bit of extra B vitamins or adding more leafy greens to your diet. Yes, for those of us with intractable health issues it can be an...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    Yes, this is VERY different. Autologous FMT taken from before one's current health issues started is definitely promising. In fact, this might be even MORE likely to work than FMT from an unrelated donor, whose microbes may not be compatible (in other words, that person's "normal" might not be...
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    Donors FMT - good Idea for my circumstance? Plus list of donor possibilities

    What I meant was, based on his own self-report his best donors were toward the beginning of his journey, which means his success declined over time. I do not think that this is an inevitable consequence of more FMTs, but it doesn't support a claim that he is getting better at picking helpful...
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    Donors Smelly donor stool

    I tried two new donors over the past three months--one male, one female, both teenagers, from the same provider. And both had quite smelly stool. I will report in full about them soon, once I know better how I did with the better of these two long-term. The female donor's stool also worse of...
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    Donors FMT - good Idea for my circumstance? Plus list of donor possibilities

    While he MAY have gotten better at avoiding truly BAD donors, keep in mind that his two most helpful donors of all time were both among the first four he tried, yet he's tried around 15 of them by now. The next two most helpful were interspersed among 10+ who didn't make decisive differences. So...
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    Autologous Autologous type-3 FMT (dark brown), Floraphage

    It's unlikely that taking your OWN microbes will help you in any way. Whatever microbes you have when your stool is the color/consistency you are aiming for are still in there when it changes, just in different proportions. Diet is causing shifts in the balance, and will still do so just as much...
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