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    Post Lyme Dysbiosis

    I have been considering putting her back on an aggressive antibiotic protocol but dont feel that is really the right course of action. I am convinced that the only viable option for her if FMT. I 100% agree that FMT is a FAR more promising option than more of an aggressive antibiotic protocol...
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    What's wrong with my gut?

    Be aware though that excess vitamin C is turned into oxalate, so if you have any oxalate issues this might actually make you worse. DO make sure you aren't seriously deficient in any vitamins, however if you supplement them, be on the lookout for any changes, good or bad. Positive changes would...
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    Why are bacteria more likely to colonize when doing FMT compared to taking regular probiotics?

    What about the studies with good results? It seems you don't even have a tag for that. It's pointless to just look at the failures and not the successes--the point is to find the things that are more common in the successful trials than the unsuccessful ones. Of course it wont be the case that...
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    Why are bacteria more likely to colonize when doing FMT compared to taking regular probiotics?

    My own experience and the experience of people I have read about (patient testimonials as well as comparing across clinical studies), this is NOT true. In fact if anything the opposite is true, where patients had good experiences with stool banks/providers who process more extensively and...
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    Why are bacteria more likely to colonize when doing FMT compared to taking regular probiotics?

    It's because they are FROM a human gut, so they are already selected for being able to survive there! SOME of the probiotic species (such as Lactobacillus acidophilus) were originally isolated from stool, but none of them have been cultivated in the gut for many, many generations. In addition...
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    FMT and COVID-19, vaccines. Any concerns about COVID vaccination affecting FMT quality? Does it matter if the donor is vaccinated?

    Marco from Gezonde Darmflora says a lot of potential recipients ask him about this. You should definitely try it. I found that I didn't really learn much of anything about which donors and methods worked for me until I started actually trying things. It's very easy to get stuck in "analysis...
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    FMT and COVID-19, vaccines. Any concerns about COVID vaccination affecting FMT quality? Does it matter if the donor is vaccinated?

    Firstly, keep in mind that there's no live virus in the vaccine, depending on the vaccine it's either a protein from the virus or a RNA molecule encoding a protein of the virus, neither of which can replicate in the human body. So the most there ever will exist is in that person's arm...
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    The power of olive oil -- significant changes to gut microbiome, stool, and food tolerances

    I've found that one of the few links between many otherwise quite different things I do poorly with is phenolic compounds--they seem as a class to be bad news for me. That's true whether they're synthetic (e.g. aspirin, 5-aminosalicylic acid, acetaminophen) or natural (quercetin, green tea)...
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    Looking for Guidance on Gut Microbiome and Brain Aging Research + PhD Proposal Editor Needed

    I'd be happy to read over your proposal. I've applied to PhD programs three times so I know what's involved. I'm also currently at an aging research center so I know that field well. This board doesn't REALLY have DM's, I mean technically it does, but the owner can read and respond to them (and...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    How long did the benefit last from the garlic and oregano? My experience with things that kill bacteria (whether antibiotics or herbs) is that even if they cause a change in the beginning, that change is lost within a week or so, even if I continue taking the medication or supplement (or go back...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I have heard secondary reports of "Lactobacillus SIBO" where the only organism found in greater-than-normal numbers in the small intestine is a species of Lactobacillus (i.e. no significant elevation in any Enterobacteriaceae, Streptococcus, Bacteroides etc.) but never any literature. I...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    First the good: I REALLY appreciate the attempt to include a broader range of bacterial diversity (both genetic and functional) than the vast majority of other probiotics. We have one sugar fermenting lactic acid bacterium (Enterococcus), one "secondary fermenter" that utilizes the lactate...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    MANY bacteria, including many probiotic strains, produce histamine. This is well studied--there are apparently probiotics that are supposed to contain low-histamine strains.
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    State of microbiome-based therapies 5-10 years from now?

    If your experience contradicts this, then that again shows how poorly your reports convey what various treatments did for you, because as I understand them by reading, nothing in your descriptions in any way goes against what I said above. First there was the fact that the four donors who...
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    Comparative study of H pylori and Streptococcus anginosus on genomes based

    You might be better off asking in a computational biology forum like Biostars or r/bioinformatics, but what are you looking to do? Are you looking to take genomes of new strains that lack gene annotations and find genes in there? or is knowing the pathways from the genomes of reference strains...
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    State of microbiome-based therapies 5-10 years from now?

    The microbiome DOES have a profound effect on mental, in addition to just physical health. However, not in the way you imagine if you are seriously asking yourself questions like this. I thought of this before my very first FMT (and before some other interventions before that)--I am on the...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    It's also a 5-HT2C (one of the serotonin receptors, that plays a role in limiting the effectiveness of SSRIs) antagonist. There are multiple fates of tryptophan--being made into protein, acting as a NAD precursor, etc. 5-HTP can ONLY be used to make serotonin and melatonin. Provided that's what...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    1. I have a degree in biochemistry and work in a neurobiology lab, and I've also looked into a lot of things as possible treatments for my own condition (which is some sort of neuro-immune condition that has never been formally diagnosed, though I see similarities to experiences of families with...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Pendulum started selling an A. muciniphila probiotic just a year or two ago. Candidatus Saccharimonas has not even been cultured, let alone commercialized, it's only known to exist by its DNA sequence that has been caught floating around in samples. Nobody even knows what the cells look like...
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    Smell and microbiome

    Do you mean the smell of your stool? or the smell of your skin/sweat? Nearly all "sulfur smell" comes from the microbiome--the sulfur-containing amino acids that make up part of our own cells don't smell strongly like sulfur, that requires that bacteria break them down into smaller, volatile...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Phages are part of the (normal) microbiome, so they're not by themselves the cause of dysbiosis or any disease. The cause of dysbiosis is essentially always either 1) excessive antibiotics, or 2) an infection of some kind (many people apparently get IBS after a bad bout of food poisoning). Some...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    I tried apple cider vinegar once, with the idea that Acetobacter species are alpha-proteobacteria and therefore belong to a different part of the bacterial tree of life than nearly all other probiotics. And they are even part of the gut microbiomes of some species, particularly insects. I made...
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    SIBO (just a symptom?), PPI's, Integrative Doctors, Functional Medicine

    This is exactly the story--both good and bad--with functional MDs/naturopaths. As you put it, they are some of the few medical professionals who accept that symptoms that are in completely different systems of the body can be connected, part of one "syndrome", and that treatments that truly heal...
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    Suppose that the gut/brain axis is as important (in psychiatry) as the peer-reviewed literature seems to indicate. Why then isn't fecal transplantation an extremely famous and celebrated psychiatric treatment?

    Even my gastroenterologist who performed my most successful FMT (back when I had C. diff) said this much. We get certain bacteria from our parents and other people we are around as babies, either directly through the birth process and/or close contact, or indirectly through the shared home...
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